سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Ghasemzadeh Rahbardar, Mahboobeh, Eisvand, Farhad, Rameshrad, Maryam, Razavi, Bibi Marjan, Tabatabaee Yazdi, Abbass, Hosseinzadeh, Hossein. (1403). Carnosic acid mitigates doxorubicin-induced cardiac toxicity: Evidence from animal and cell model investigations. , 27(4), 425-438. doi: 10.22038/ijbms.2023.71508.15544
Mahboobeh Ghasemzadeh Rahbardar; Farhad Eisvand; Maryam Rameshrad; Bibi Marjan Razavi; Abbass Tabatabaee Yazdi; Hossein Hosseinzadeh. "Carnosic acid mitigates doxorubicin-induced cardiac toxicity: Evidence from animal and cell model investigations". , 27, 4, 1403, 425-438. doi: 10.22038/ijbms.2023.71508.15544
Ghasemzadeh Rahbardar, Mahboobeh, Eisvand, Farhad, Rameshrad, Maryam, Razavi, Bibi Marjan, Tabatabaee Yazdi, Abbass, Hosseinzadeh, Hossein. (1403). 'Carnosic acid mitigates doxorubicin-induced cardiac toxicity: Evidence from animal and cell model investigations', , 27(4), pp. 425-438. doi: 10.22038/ijbms.2023.71508.15544
Ghasemzadeh Rahbardar, Mahboobeh, Eisvand, Farhad, Rameshrad, Maryam, Razavi, Bibi Marjan, Tabatabaee Yazdi, Abbass, Hosseinzadeh, Hossein. Carnosic acid mitigates doxorubicin-induced cardiac toxicity: Evidence from animal and cell model investigations. , 1403; 27(4): 425-438. doi: 10.22038/ijbms.2023.71508.15544

Carnosic acid mitigates doxorubicin-induced cardiac toxicity: Evidence from animal and cell model investigations

Iranian Journal of Basic Medical Sciences
مقاله 4، دوره 27، شماره 4، تیر 2024، صفحه 425-438    اصل مقاله (1.38 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.71508.15544
نویسندگان
Mahboobeh Ghasemzadeh Rahbardar1؛ Farhad Eisvand2؛ Maryam Rameshrad2؛ Bibi Marjan Razavi2، 3؛ Abbass Tabatabaee Yazdi4؛ Hossein Hosseinzadeh* 1، 2
1Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
4Ghaem Hospital, Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): Utilization of doxorubicin (DOX) as a chemotherapy medication is limited due to its cardiotoxic effects. Carnosic acid exerts antioxidant, anti-inflammatory, besides cytoprotective effects. The objective of this study was to investigate the ability of carnosic acid to protect rat hearts and the MCF7 cell line against cardiotoxicity induced by DOX.
Materials and Methods: The study involved the classification of male Wistar rats into seven groups: 1) Control 2) DOX (2 mg/kg, every 48h, IP, 12d), 3-5) Carnosic acid (10, 20, 40 mg/kg/day, IP, 16d)+ DOX, 6) Vitamin E (200 mg/kg, every 48h, IP, 16d)+ DOX 7) Carnosic acid (40 mg/kg/day, IP, 16d). Finally, cardiac histopathological alterations, ECG factors, carotid blood pressure, left ventricular function, heart-to-body weight ratio, oxidative (MDA, GSH), inflammatory (IL-1β, TNF-α), plus apoptosis (caspase 3, 8, 9, Bcl-2, Bax) markers were evaluated. DOX toxicity and carnosic acid ameliorative effect were evaluated on MCF7 cells using the MTT assay.
Results: DOX augmented the QRS duration, QA, RRI, STI, and heart-to-body weight ratio, and reduced HR, LVDP, Min dP/dt, Max dP/dt, blood pressure, boosted MDA, TNF-α, IL1-β, caspase 3,8,9, Bax/Bcl-2 ratio, decreased GSH content, caused fibrosis, necrosis, and cytoplasmic vacuolization in cardiac tissue but carnosic acid administration reduced the toxic effects of DOX. The cytotoxic effects of DOX were not affected by carnosic acid at concentrations of 5 and 10 μM.
Conclusion: Carnosic acid as an anti-inflammatory and antioxidant substance is effective in reducing DOX-induced damage by enhancing antioxidant defense and modifying inflammatory signal pathway activity and can be used as an adjunct in treating DOX cardiotoxicity.
کلیدواژه‌ها
Anti-Inflammatory agents؛ Antioxidants؛ Cardiotoxicity؛ Electrocardiography؛ Salvin؛ Vitamin E
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