سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Nazari Rad, Mehrnaz, Akhondian, Javad, Alamdaran, Seyed Ali, Rezaeian, Aramesh, khakshour, Ali, Abbasi Shaye, Zahra, Sayedi, Seyed Javad. (1402). The Effects of Botulinum Toxin Type A on Reducing Sialorrhea in Children with Cerebral Palsy: A Self-Controlled Clinical Trial. , 11(12), 18406-18412. doi: 10.22038/ijp.2023.75995.5385
Mehrnaz Nazari Rad; Javad Akhondian; Seyed Ali Alamdaran; Aramesh Rezaeian; Ali khakshour; Zahra Abbasi Shaye; Seyed Javad Sayedi. "The Effects of Botulinum Toxin Type A on Reducing Sialorrhea in Children with Cerebral Palsy: A Self-Controlled Clinical Trial". , 11, 12, 1402, 18406-18412. doi: 10.22038/ijp.2023.75995.5385
Nazari Rad, Mehrnaz, Akhondian, Javad, Alamdaran, Seyed Ali, Rezaeian, Aramesh, khakshour, Ali, Abbasi Shaye, Zahra, Sayedi, Seyed Javad. (1402). 'The Effects of Botulinum Toxin Type A on Reducing Sialorrhea in Children with Cerebral Palsy: A Self-Controlled Clinical Trial', , 11(12), pp. 18406-18412. doi: 10.22038/ijp.2023.75995.5385
Nazari Rad, Mehrnaz, Akhondian, Javad, Alamdaran, Seyed Ali, Rezaeian, Aramesh, khakshour, Ali, Abbasi Shaye, Zahra, Sayedi, Seyed Javad. The Effects of Botulinum Toxin Type A on Reducing Sialorrhea in Children with Cerebral Palsy: A Self-Controlled Clinical Trial. , 1402; 11(12): 18406-18412. doi: 10.22038/ijp.2023.75995.5385

The Effects of Botulinum Toxin Type A on Reducing Sialorrhea in Children with Cerebral Palsy: A Self-Controlled Clinical Trial

International Journal of Pediatrics
دوره 11، شماره 12، اسفند 2023، صفحه 18406-18412    اصل مقاله (186.81 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2023.75995.5385
نویسندگان
Mehrnaz Nazari Rad1؛ Javad Akhondian2؛ Seyed Ali Alamdaran3؛ Aramesh Rezaeian4؛ Ali khakshour5؛ Zahra Abbasi Shaye* 6؛ Seyed Javad Sayedi* 7
1Department of Pediatrics, School of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Pediatric Neurology Ward, Mashhad University of Medical Sciences
3Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5Assistant Professor of Pediatric. Mashhad University of Medical Sciences, Mashhad, Iran.
6Clinical Research Development Center, Akbar Hospital, Faculty of Medicine, Mashhad University of medical sciences, Mashhad, Iran
7Assistant Prof of Pediatric Pulmonology, Mashhad University of Medical Sciences
چکیده
Background: Cerebral palsy stands as the main cause of mobility disability in childhood, and the accompanying sialorrhea exacerbates health and psychological issues for both the child and the family. We aimed to assess the effect of botulinum toxin type A on reducing sialorrhea in children with cerebral palsy.
Methods: This self-controlled clinical trial was executed among children afflicted with cerebral palsy. The Teacher Drooling Scale was used as the data collection tool. The intervention involved the administration of botulinum toxin A, with a dosage ranging from 30 to 50 units in each parotid gland, skillfully guided by a radiologist using ultrasound. Sialorrhea scores were compared before and after the injection.
Results: Our study included 21 children with cerebral palsy and sialorrhea. After the two post-injection weeks, a noteworthy drop was observed in the sialorrhea score (4.10±0.831) compared to the pre-injection score (4.71±0.463). The sialorrhea score until the ninth month after injection (1.121±3.43) was still significantly lower than the score before injection.
Conclusion: The injection of botulinum toxin A emerges as a potent medication, significantly curtailing the drooling among patients with cerebral palsy. This finding can be used to prevent aspiration pneumonia and reduce social and psychological complications in this population.
کلیدواژه‌ها
Botulinum Toxins Type A,,؛ ,،Cerebral Palsy,,؛ ,،Sialorrhea
مراجع
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