سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Ajibade, Temitayo, Esan, Oluwaseun, Osawere, Isreal, Adetona, Moses, Aina, Oluwasanmi, Azeez, Odunayo, Obisesan, Ayobami Deborah, Oyagbemi, Ademola Adetokunbo, Ola-Davies, Olufunke Eunice, Omobowale, Temidayo, Saba, Adebowale, Adedapo, Adeolu, Yakubu, Momoh, Oguntibeju, Oluwafemi. (1402). Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats. , 14(2), 202-214. doi: 10.22038/ajp.2023.23367
Temitayo Olabisi Ajibade; Oluwaseun Olanrewaju Esan; Isreal Mark Osawere; Moses Olusola Adetona; Oluwasanmi Olayinka Aina; Odunayo Ibraheem Azeez; Ayobami Deborah Obisesan; Ademola Adetokunbo Oyagbemi; Olufunke Eunice Eunice Ola-Davies; Temidayo Olutayo Omobowale; Adebowale Benard Saba; Adeolu Alex Adedapo; Momoh Audu Yakubu; Oluwafemi Omoniyi Oguntibeju. "Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats". , 14, 2, 1402, 202-214. doi: 10.22038/ajp.2023.23367
Ajibade, Temitayo, Esan, Oluwaseun, Osawere, Isreal, Adetona, Moses, Aina, Oluwasanmi, Azeez, Odunayo, Obisesan, Ayobami Deborah, Oyagbemi, Ademola Adetokunbo, Ola-Davies, Olufunke Eunice, Omobowale, Temidayo, Saba, Adebowale, Adedapo, Adeolu, Yakubu, Momoh, Oguntibeju, Oluwafemi. (1402). 'Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats', , 14(2), pp. 202-214. doi: 10.22038/ajp.2023.23367
Ajibade, Temitayo, Esan, Oluwaseun, Osawere, Isreal, Adetona, Moses, Aina, Oluwasanmi, Azeez, Odunayo, Obisesan, Ayobami Deborah, Oyagbemi, Ademola Adetokunbo, Ola-Davies, Olufunke Eunice, Omobowale, Temidayo, Saba, Adebowale, Adedapo, Adeolu, Yakubu, Momoh, Oguntibeju, Oluwafemi. Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats. , 1402; 14(2): 202-214. doi: 10.22038/ajp.2023.23367

Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats

Avicenna Journal of Phytomedicine
دوره 14، شماره 2، خرداد و تیر 2024، صفحه 202-214    اصل مقاله (1.06 M)
نوع مقاله: Original Research Article
شناسه دیجیتال (DOI): 10.22038/ajp.2023.23367
نویسندگان
Temitayo Olabisi Ajibade1؛ Oluwaseun Olanrewaju Esan* 2؛ Isreal Mark Osawere1؛ Moses Olusola Adetona3؛ Oluwasanmi Olayinka Aina4؛ Odunayo Ibraheem Azeez1؛ Ayobami Deborah Obisesan5؛ Ademola Adetokunbo Oyagbemi1؛ Olufunke Eunice Eunice Ola-Davies1؛ Temidayo Olutayo Omobowale2؛ Adebowale Benard Saba5؛ Adeolu Alex Adedapo5؛ Momoh Audu Yakubu6؛ Oluwafemi Omoniyi Oguntibeju7
1Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeria
2Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria
3Department of Anatomy, Faculty of Basic Medical Sciences, University of Ibadan, Nigeria
4Department of Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Nigeria
5Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria
6Department of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, COPHS,Texas Southern University, Houston, TX, USA
7Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa
چکیده
Objective: Curcuma longa Rhizome (CLR), due to its potent antioxidant phytochemical constituents, was investigated for its effects on bisphenol A (BPA)-induced cardiovascular and renal damage.
Materials and Methods: Sixty rats were randomly selected, and grouped as control, BPA (100 mg/ kg), BPA and CLR 100 mg/kg, BPA and CLR 200 mg/kg, CLR 100 mg/kg, and CLR 200 mg/kg for 21 days. Oxidative stress indices, antioxidant status, blood pressure parameters, genotoxicity, and immunohistochemistry were determined.
Results: Rats exposed to the toxic effects of BPA had heightened blood pressure, lowered frequency of micronucleated polychromatic erythrocytes, and decreased activities of antioxidant enzymes compared with rats treated with CLR. Moreover, administration of CLR significantly (p<0.05) lowered malondialdehyde content and reduced the serum myeloperoxidase activity. Immunohistochemical evaluation revealed significantly (p<0.05) increased expressions of cardiac troponin and Caspase 3 in the BPA group compared with the CLR-treated groups.
Conclusion: C. longa ameliorated cardiotoxic and nephrotoxic actions of bisphenol-A via mitigation of oxidative stress, hypertension, and genotoxicity.
کلیدواژه‌ها
Bisphenol A؛ Curcuma longa؛ Rat؛ Antioxidant؛ Anti-inflammatory
آمار
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