Simultaneous Effect of Atorvastatin and Combined Training on lipid and hepatic enzymes in Rats induced Non-Alcoholic Fatty Liver Disease | ||
| Journal of Nutrition,Fasting and Health | ||
| مقاله 10، دوره 11، شماره 3، پاییز 2023، صفحه 246-252 اصل مقاله (942.51 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22038/jnfh.2023.75312.1466 | ||
| نویسندگان | ||
| Seyed Ali Mirghani1؛ Mania Roozbayani* 2؛ Saleh Rahmati3؛ Lida Moradi4 | ||
| 1Department of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University Tehran, Iran. | ||
| 2Department of Exercise Physiology, CT.C., Islamic Azad University, Tehran, Iran. | ||
| 3Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran. | ||
| 4Department of Physical Education and Sports Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran. | ||
| چکیده | ||
| Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, the prevalence of which is increasing. This study aimed to evaluate the effect of atorvastatin and combined training in NAFLD-induced rats. Methods: This study was conducted on 21 male Wistar rats, divided into two groups: 1) HFFD + combined training + atorvastatin and 2) HFFD + atorvastatin. The groups received HFFD for 15 weeks to induce NAFLD. Atorvastatin was administrated at the dose of 2mg/kg/day. The interventions (atorvastatin and combined training) were performed for eight weeks. Results: Alanine transaminase (ALT) was significantly reduced, and high-density lipoprotein (HDL) was increased in the HFFD + atorvastatin group. Low-density lipoprotein (LDL) decreased significantly in the HFFD + combined training + atorvastatin. There was no significant difference in the aspartate transaminase (AST), triglyceride (TG), alkaline phosphatase (ALP), and weight between the groups. Conclusion: Based on the findings, Atorvastatin, along with combined training, improved NAFLD. Therefore, they can be used to reduce the complications of NAFLD. However, more studies are needed to confirm the results. | ||
| کلیدواژهها | ||
| Atorvastatin؛ High-fat-fructose diet؛ Non-alcoholic fatty liver disease؛ Combined training | ||
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