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Reihani, Amin, Mohammadi, Hamidreza. (1402). Evaluation of Methamphetamine, Methadone, Tramadol, Diazinon, Phosalone, Trichlorfon, Mancozeb, and Penconazole in Hand-made Alcoholic Beverages in North Khorasan Province, Iran. , 12(3), 92-96. doi: 10.22038/apjmt.2023.23262
Amin Reihani; Hamidreza Mohammadi. "Evaluation of Methamphetamine, Methadone, Tramadol, Diazinon, Phosalone, Trichlorfon, Mancozeb, and Penconazole in Hand-made Alcoholic Beverages in North Khorasan Province, Iran". , 12, 3, 1402, 92-96. doi: 10.22038/apjmt.2023.23262
Reihani, Amin, Mohammadi, Hamidreza. (1402). 'Evaluation of Methamphetamine, Methadone, Tramadol, Diazinon, Phosalone, Trichlorfon, Mancozeb, and Penconazole in Hand-made Alcoholic Beverages in North Khorasan Province, Iran', , 12(3), pp. 92-96. doi: 10.22038/apjmt.2023.23262
Reihani, Amin, Mohammadi, Hamidreza. Evaluation of Methamphetamine, Methadone, Tramadol, Diazinon, Phosalone, Trichlorfon, Mancozeb, and Penconazole in Hand-made Alcoholic Beverages in North Khorasan Province, Iran. , 1402; 12(3): 92-96. doi: 10.22038/apjmt.2023.23262

Evaluation of Methamphetamine, Methadone, Tramadol, Diazinon, Phosalone, Trichlorfon, Mancozeb, and Penconazole in Hand-made Alcoholic Beverages in North Khorasan Province, Iran

Asia Pacific Journal of Medical Toxicology
دوره 12، شماره 3، آذر 2023، صفحه 92-96    اصل مقاله (726.15 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/apjmt.2023.23262
نویسندگان
Amin Reihani1؛ Hamidreza Mohammadi* 2
1Mazandaran University of Medical Sciences
2Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: Unrecorded alcoholic beverage consumption is a health problem in Iran. Extensive use of pesticides in agricultural products may lead to the presence of residues of these compounds in hand-made alcoholic beverages. There are claims that the producer of hand-made alcoholic beverages adds some drugs to increase efficiency. The objective of this study was to assess the presence of methamphetamine, methadone, tramadol, diazinon, phosalone, trichlorfon, mancozeb, and penconazole in homemade alcoholic drinks.
Methods: Thirty hand-made alcoholic beverages were analyzed in this study. Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) and liquid-liquid extraction (LLE) were selected for samples' pretreatment. Gas chromatography-mass spectrometry (GC-MS) was used to identify diazinon, phosalone, trichlorfon, mancozeb, and penconazole and high-performance liquid chromatography (HPLC) was used to identify tramadol, methadone, and methamphetamine.
Results: This study showed that diazinon was detected in three samples (10% of the total samples) at 10.8 to 16.5 μg/L and Penconazole was detected in two samples (6% of the whole samples) at a range of 78.5 to 810.6 μg/L. However, Mancozeb, trichlorfon, and phosalone were not in alcoholic beverages. In addition, methadone, tramadol, and methamphetamine were not detected in any samples.
Conclusion: The results of our research showed that hand-made alcoholic beverages contain pesticide residues, and the use of these beverages causes diseases in the body.
 
 
کلیدواژه‌ها
Alcoholic beverages؛ Diazinon؛ Mancozeb؛ Methamphetamine؛ Methadone
مراجع
  1. Aylott R. Analytical strategies supporting protected designations of origin for alcoholic beverages. Comprehensive Analytical Chemistry. 60: Elsevier; 2013. p. 409-38.
  2. Arslan MM, Zeren C, Aydin Z, Akcan R, Dokuyucu R, Keten A, et al. Analysis of methanol and its derivatives in illegally produced alcoholic beverages. Journal of forensic and legal medicine. 2015;33:56-60.
  3. Organization WH. Global status report on alcohol and health 2018: executive summary. World Health Organization; 2018.
  4. Pflaum T, Hausler T, Baumung C, Ackermann S, Kuballa T, Rehm J, et al. Carcinogenic compounds in alcoholic beverages: an update. Archives of toxicology. 2016;90(10):2349-67.
  5. Dadpour B, Hedjazi A, Ghorbani H, Khosrojerdi H, Vaziri SM, Zadeh HM, et al. Chemical components of noncommercial alcohol beverage samples: A study with the viewpoint of toxic components in Mashhad, Iran. International journal of high risk behaviors & addiction. 2016;5(2).
  6. Cabras P, Angioni A. Pesticide residues in grapes, wine, and their processing products. Journal of agricultural and food chemistry. 2000;48(4):967-73.
  7. Guo T, Fang P, Jiang J, Zhang F, Yong W, Liu J, et al. Rapid screening and quantification of residual pesticides and illegal adulterants in red wine by direct analysis in real time mass spectrometry. Journal of chromatography A. 2016;1471:27-33.
  8. Grewal A. Pesticide Res-idues in Food Grains, Vegetables and Fruits: A Hazard to Human Health.(2017) J Med Chem Toxicol 2 (1): 1-7. J Med Chem Toxicol. 2017;2(1).
  9. Magrini L, Cappiello A, Famiglini G, Palma P. Microextraction by packed sorbent (MEPS)-UHPLC-UV: a simple and efficient method for the determination of five benzodiazepines in an alcoholic beverage. Journal of Pharmaceutical and Biomedical Analysis. 2016;125:48-53.
  10. . The Journal Of New Advances In Behavioral Sciences. 2020;5(48):28-42.
  11. Jovanov P, Guzsvány V, Franko M, Lazić S, Sakač M, Milovanović I, et al. Development of multiresidue DLLME and QuEChERS based LC–MS/MS method for determination of selected neonicotinoid insecticides in honey liqueur. Food research international. 2014;55:11-9.
  12. Anastassiades M, Lehotay S, Schenck F. QuEChERS procedure for multi-residue pesticide analysis. Journal of AOAC International. 2003;86:1-8.
  13. Clarke EGC. Clarke's analysis of drugs and poisons: in pharmaceuticals, body fluids and postmortem material: Pharmaceutical Press; 2004.
  14. Moffat AC, Osselton MD, Widdop B, Watts J. Clarke's analysis of drugs and poisons: Pharmaceutical press London; 2011.
  15. Tomasi D, Gaiotti F, Jones G. Organoleptic Characteristics of the Wines. 2013. p. 149-66.
  16. Chłobowska Z, Chudzikiewicz E, Świegoda C. Analysis of alcoholic products at the Institute of Forensic Research. Z Zagadnień Nauk Sądowych. 2000;41:52-61.
  17. Al Nasir FM, Jiries AG, Batarseh MI, Beese F. Pesticides and trace metals residue in grape and home made wine in Jordan. Environmental monitoring and assessment. 2001;66:253-63.
  18. Mali B, Garad M. Thin-layer chromatographic detection of chloral hydrate in an alcoholic beverage. JPC-Journal of Planar Chromatography-Modern TLC. 2005;18(105):397-9.
  19. Ghadirzadeh MR, Nazari SSH, Mirtorabi D, Fattahi A. Tramadol, methadone and benzodiazepines added to alcoholic beverages. Alcohol and alcoholism. 2019;54(4):435-8.
  20. Kosma CI, Koloka OL, Albanis TA, Konstantinou IK. Accurate mass screening of pesticide residues in wine by modified QuEChERS and LC-hybrid LTQ/Orbitrap-MS. Food Chemistry. 2021;360:130008.
  21. Pelegrín CJ, Flores Y, Jiménez A, Garrigós MC. Recent trends in the analysis of chemical contaminants in beverages. Beverages. 2020;6(2):32.
  22. Cladière M, Delaporte G, Le Roux E, Camel V. Multi-class analysis for simultaneous determination of pesticides, mycotoxins, process-induced toxicants and packaging contaminants in tea. Food chemistry. 2018;242:113-21.
  23. Bolaños PP, Romero-González R, Frenich AG, Vidal JM. Application of hollow fibre liquid phase microextraction for the multiresidue determination of pesticides in alcoholic beverages by ultra-high pressure liquid chromatography coupled to tandem mass spectrometry. Journal of Chromatography A. 2008;1208(1-2):16-24.
  24. Dias JV, Maria da Graça PN, Pizzutti IR, Reichert B, Jung AA, Cardoso CD. Simultaneous determination of pesticides and mycotoxins in wine by direct injection and liquid chromatography-tandem mass spectrometry analysis. Food chemistry. 2019;293:83-91.
  25. dos Anjos JP, de Andrade JB. Determination of nineteen pesticides residues (organophosphates, organochlorine, pyrethroids, carbamate, thiocarbamate and strobilurin) in coconut water by SDME/GC–MS. Microchemical Journal. 2014;112:119-26.
  26. Anastassiades M, Lehotay SJ, Štajnbaher D, Schenck FJ. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “dispersive solid-phase extraction” for the determination of pesticide residues in produce. Journal of AOAC international. 2003;86(2):412-31.
  27. Bernardi G, Kemmerich M, Adaime MB, Prestes OD, Zanella R. Miniaturized QuEChERS method for determination of 97 pesticide residues in wine by ultra-high performance liquid chromatography coupled with tandem mass spectrometry. Analytical Methods. 2020;12(21):2682-92.
  28. Morteza Z, Mousavi SB, Baghestani MA, Aitio A. An assessment of agricultural pesticide use in Iran, 2012-2014. Journal of Environmental Health Science and Engineering. 2017;15(1):1-8.
  29. Hadian Z, Eslamizad S, Yazdanpanah H. Pesticide residues analysis in Iranian fruits and vegetables by Gas Chromatography-Mass Spectrometry. Iranian journal of pharmaceutical research: IJPR. 2019;18(1):275.
  30. Pirsaheb M, Fattahi N, Rahimi R, Sharafi K, Ghaffari HR. Evaluation of abamectin, diazinon and chlorpyrifos pesticide residues in apple product of Mahabad region gardens: Iran in 2014. Food chemistry. 2017;231:148-55.
           

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