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Yalçin, Tuba, Kuloglu, Tuncay, Kaya Tektemur, Nalan, Tektemur, Ahmet, Ozan, İbrahim. (1402). Effects of N-acetylcysteine on spexin immunoreactivity in kidney tissues of rats treated with adriamycin. , 27(2), 233-240. doi: 10.22038/ijbms.2023.71942.15635
Tuba Yalçin; Tuncay Kuloglu; Nalan Kaya Tektemur; Ahmet Tektemur; İbrahim Enver Ozan. "Effects of N-acetylcysteine on spexin immunoreactivity in kidney tissues of rats treated with adriamycin". , 27, 2, 1402, 233-240. doi: 10.22038/ijbms.2023.71942.15635
Yalçin, Tuba, Kuloglu, Tuncay, Kaya Tektemur, Nalan, Tektemur, Ahmet, Ozan, İbrahim. (1402). 'Effects of N-acetylcysteine on spexin immunoreactivity in kidney tissues of rats treated with adriamycin', , 27(2), pp. 233-240. doi: 10.22038/ijbms.2023.71942.15635
Yalçin, Tuba, Kuloglu, Tuncay, Kaya Tektemur, Nalan, Tektemur, Ahmet, Ozan, İbrahim. Effects of N-acetylcysteine on spexin immunoreactivity in kidney tissues of rats treated with adriamycin. , 1402; 27(2): 233-240. doi: 10.22038/ijbms.2023.71942.15635

Effects of N-acetylcysteine on spexin immunoreactivity in kidney tissues of rats treated with adriamycin

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 27، شماره 2، اردیبهشت 2024، صفحه 233-240    اصل مقاله (633.97 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.71942.15635
نویسندگان
Tuba Yalçin* 1؛ Tuncay Kuloglu2؛ Nalan Kaya Tektemur2؛ Ahmet Tektemur3؛ İbrahim Enver Ozan2
1Batman University, Health Services Vocational School, First and Emergency Program, Batman, Turkey
2Firat University, Medicine Faculty, Department of Histology and Embryology, Elazığ, Turkey
3Firat University, Medicine Faculty, Department of Medical Biology, Elazığ, Turkey
چکیده
Objective(s): Due to its negative side effects, mainly nephrotoxicity, adriamycin (ADR) is used fairly infrequently. The purpose of this study is to investigate the effects of N-acetyl cysteine (NAC) on the immunoreactivity of spexin (SPX) in the kidney tissues of rats given ADR.
Materials and Methods: A total of 28 male Sprague-Dawley rats were randomly assigned to four groups (n=7): control (no intervention), NAC (150 mg/kg/day, administered intraperitoneally), ADR (single dose of 15 mg/kg, administered intraperitoneally), and ADR+NAC (single dose of 15 mg/kg ADR + 150 mg/kg/day NAC, both administered intraperitoneally). The experiment was concluded on the 15th day. 
Results: The administration of ADR resulted in biochemical and histopathological alterations in the kidney. It was found that ADR treatment led to elevated levels of TOS (total oxidative stress), apoptosis, and SPX. Conversely, when NAC was administered as a treatment, it effectively reduced TOS, apoptosis, and SPX levels. These findings suggest that SPX may contribute to the development of ADR-induced kidney damage.
Conclusion: Further investigations are warranted to gain a comprehensive understanding of kidney damage, and specifically to elucidate the role of SPX in this context. Additionally, these studies can pave the way for exploring novel therapeutic strategies targeting SPX to prevent and/or treat the development of kidney damage.
کلیدواژه‌ها
Adriamycin؛ N-Acetylcysteine؛ Nephrotoxicity؛ Neuropeptide Q؛ Spexin
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