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Mohamadzdeh, Aliyeh, Fallahi, Minoo, Hajipour, Mahmoud, Amirshahi, Aliraza, Kazemian, Mohammad. (1402). Evaluating the Value of Quadruple Thyroid Screening in the Diagnosis of Hypothyroidism among Premature Neonates in Tehran in 2019-2020. , 15(1), 21-26. doi: 10.22038/ijn.2023.69619.2347
Aliyeh Mohamadzdeh; Minoo Fallahi; Mahmoud Hajipour; Aliraza Amirshahi; Mohammad Kazemian. "Evaluating the Value of Quadruple Thyroid Screening in the Diagnosis of Hypothyroidism among Premature Neonates in Tehran in 2019-2020". , 15, 1, 1402, 21-26. doi: 10.22038/ijn.2023.69619.2347
Mohamadzdeh, Aliyeh, Fallahi, Minoo, Hajipour, Mahmoud, Amirshahi, Aliraza, Kazemian, Mohammad. (1402). 'Evaluating the Value of Quadruple Thyroid Screening in the Diagnosis of Hypothyroidism among Premature Neonates in Tehran in 2019-2020', , 15(1), pp. 21-26. doi: 10.22038/ijn.2023.69619.2347
Mohamadzdeh, Aliyeh, Fallahi, Minoo, Hajipour, Mahmoud, Amirshahi, Aliraza, Kazemian, Mohammad. Evaluating the Value of Quadruple Thyroid Screening in the Diagnosis of Hypothyroidism among Premature Neonates in Tehran in 2019-2020. , 1402; 15(1): 21-26. doi: 10.22038/ijn.2023.69619.2347

Evaluating the Value of Quadruple Thyroid Screening in the Diagnosis of Hypothyroidism among Premature Neonates in Tehran in 2019-2020

Iranian Journal of Neonatology
مقاله 4، دوره 15، شماره 1، فروردین 2024، صفحه 21-26    اصل مقاله (614.07 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijn.2023.69619.2347
نویسندگان
Aliyeh Mohamadzdeh1؛ Minoo Fallahi* 2؛ Mahmoud Hajipour3؛ Aliraza Amirshahi4؛ Mohammad Kazemian2
1Neonatal Health Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Department of Pediatrics, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
2Neonatal Health Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Computer Engineering, Kashan branch, Islamic Azad University, Kashan, Iran
چکیده
Background: Neonate screening is a preventative measure that can contribute to early diagnosis of treatable diseases. Hypothyroidism in neonates is among the common preventable factors leading to intellectual disability. This study aims to describe the prevalence and experience with four-step screening to diagnose congenital hypothyroidism.
Methods: The statistical population of this cross-sectional study included 392 preterm neonates (gestational ages less than 36 weeks and 6 days) in 2018-2019 from the health centers covered by Shahid Beheshti University of Medical Sciences (Tehran, Iran) who had been referred for screening. Neonates were screened in the first 3-6 days after birth and then on days 14, 42, and 72. In neonates with TSH serum levels of 10 mU/L, TSH-T4 was measured. Next, the physician decided on the medication based on the results.
Results: At the primary screening of the neonates average TSH level was 2.08 ± 2.4 mU/L. Thirty-three neonates (8.4%) indicated disrupted screening results. The secondary screening of 388 neonates (98.97%) revealed an average TSH serum level of 1.9 ± 1.96 mU/L, and 19 (5.9%) indicated TSH serum levels higher than 5 (mU/L). The third screening test was performed on 382 (97.44%) of the neonates. The average TSH level was 1.3 ± 2.4 mU/L, 340 (85.96%) indicated normal levels, and 42 (11.47%) had unfavorable results. Finally, the fourth screening test was performed on 373 (95.15%) neonates. The mean TSH level was 2.21 ± 1.9 mU/L, which revealed 24 (6.12%) unfavorable test results. The percentage of hypothyroidism in neonates was 5.6% (23 cases).  In this study, the prevalence of hypothyroidism was 4.33% (17 cases) in girls and 1.53% (6 cases) in boys.   
Conclusion: The results of this study revealed the high incidence rate of congenital hypothyroidism among preterm neonates. Therefore, preventing congenital hypothyroidism misdiagnosis requires a series of screening tests. Also, findings indicated that the results of screening tests for preterm neonates with prolonged GAs and higher birth weights are more accurate and reliable.
 
 
کلیدواژه‌ها
Hypothyroidism؛ Neonate؛ Screening test
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آمار
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