سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Gong, Yating, Qiu, Beibei, Zheng, Haotian, Li, Xiangbo, Wang, Yifan, Wu, Mengran, Yan, Meixing, Gong, Yanling. (1402). Unacylated ghrelin attenuates acute liver injury and hyperlipidemia via its anti-inflammatory and anti-oxidative activities. , 27(1), 49-56. doi: 10.22038/ijbms.2023.70831.15388
Yating Gong; Beibei Qiu; Haotian Zheng; Xiangbo Li; Yifan Wang; Mengran Wu; Meixing Yan; Yanling Gong. "Unacylated ghrelin attenuates acute liver injury and hyperlipidemia via its anti-inflammatory and anti-oxidative activities". , 27, 1, 1402, 49-56. doi: 10.22038/ijbms.2023.70831.15388
Gong, Yating, Qiu, Beibei, Zheng, Haotian, Li, Xiangbo, Wang, Yifan, Wu, Mengran, Yan, Meixing, Gong, Yanling. (1402). 'Unacylated ghrelin attenuates acute liver injury and hyperlipidemia via its anti-inflammatory and anti-oxidative activities', , 27(1), pp. 49-56. doi: 10.22038/ijbms.2023.70831.15388
Gong, Yating, Qiu, Beibei, Zheng, Haotian, Li, Xiangbo, Wang, Yifan, Wu, Mengran, Yan, Meixing, Gong, Yanling. Unacylated ghrelin attenuates acute liver injury and hyperlipidemia via its anti-inflammatory and anti-oxidative activities. , 1402; 27(1): 49-56. doi: 10.22038/ijbms.2023.70831.15388

Unacylated ghrelin attenuates acute liver injury and hyperlipidemia via its anti-inflammatory and anti-oxidative activities

Iranian Journal of Basic Medical Sciences
مقاله 8، دوره 27، شماره 1، فروردین 2024، صفحه 49-56    اصل مقاله (514.11 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.70831.15388
نویسندگان
Yating Gong1؛ Beibei Qiu2؛ Haotian Zheng3؛ Xiangbo Li3؛ Yifan Wang3؛ Mengran Wu3؛ Meixing Yan4؛ Yanling Gong* 5
1Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China
2Department of Pathology, Feicheng Hospital Affiliated to Shandong First Medical University, Qingdao, China
3Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China
4Department of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao, China
5Department of Pharmacy College of Chemical Engineering Qingdao University of Science and Technology Qingdao, 266042 China
چکیده
Objective(s): Liver injury and hyperlipidemia are major issues that have drawn more and more attention in recent years. The present study aimed to investigate the effects of unacylated ghrelin (UAG) on acute liver injury and hyperlipidemia in mice.
Materials and Methods: UAG was injected intraperitoneally once a day for three days. Three hours after the last administration, acute liver injury was induced by intraperitoneal injection of carbon tetrachloride (CCl4), and acute hyperlipidemia was induced by intraperitoneal injection of poloxamer 407, respectively. Twenty-four hours later, samples were collected for serum biochemistry analysis, histopathological examination, and Western blotting.
Results: In acute liver injury mice, UAG significantly decreased liver index, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), reduced malondialdehyde (MDA) concentration and increased superoxide dismutase(SOD) in liver tissue. NF-kappa B (NF-κB) protein expression in the liver was down-regulated. In acute hyperlipidemia mice, UAG significantly decreased serum total cholesterol (TC), triglyceride (TG), ALT, and AST, as well as hepatic TG levels. Meanwhile, hepatic MDA decreased and SOD increased significantly. Moreover, UAG improved the pathological damage in the liver induced by CCl4 and poloxamer 407, respectively.
Conclusion: Intraperitoneal injection of UAG exhibited hepatoprotective and lipid-lowering effects on acute liver injury and hyperlipidemia, which is attributed to its anti-inflammatory and anti-oxidant activities. 
کلیدواژه‌ها
Anti-inflammatory؛ Anti-oxidative؛ Hyperlipidemia؛ Intraperitoneal injection؛ Liver injury؛ Unacylated ghrelin
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