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Kawaji, Kodai, Kurata, Seiji, Matsuo, Katsuhisa, Miyoshi, Hiroaki, Akiba, Jun, Mouri, Fumihiko, Sumi, Akiko, Fujimoto, Kiminori, Abe, Toshi. (1402). 18F-FDG PET/CT imaging of IgG4-producing MALT lymphoma with multiple site involvement. , 12(1), 52-56. doi: 10.22038/aojnmb.2023.73477.1512
Kodai Kawaji; Seiji Kurata; Katsuhisa Matsuo; Hiroaki Miyoshi; Jun Akiba; Fumihiko Mouri; Akiko Sumi; Kiminori Fujimoto; Toshi Abe. "18F-FDG PET/CT imaging of IgG4-producing MALT lymphoma with multiple site involvement". , 12, 1, 1402, 52-56. doi: 10.22038/aojnmb.2023.73477.1512
Kawaji, Kodai, Kurata, Seiji, Matsuo, Katsuhisa, Miyoshi, Hiroaki, Akiba, Jun, Mouri, Fumihiko, Sumi, Akiko, Fujimoto, Kiminori, Abe, Toshi. (1402). '18F-FDG PET/CT imaging of IgG4-producing MALT lymphoma with multiple site involvement', , 12(1), pp. 52-56. doi: 10.22038/aojnmb.2023.73477.1512
Kawaji, Kodai, Kurata, Seiji, Matsuo, Katsuhisa, Miyoshi, Hiroaki, Akiba, Jun, Mouri, Fumihiko, Sumi, Akiko, Fujimoto, Kiminori, Abe, Toshi. 18F-FDG PET/CT imaging of IgG4-producing MALT lymphoma with multiple site involvement. , 1402; 12(1): 52-56. doi: 10.22038/aojnmb.2023.73477.1512

18F-FDG PET/CT imaging of IgG4-producing MALT lymphoma with multiple site involvement

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 9، دوره 12، شماره 1، فروردین 2024، صفحه 52-56    اصل مقاله (1.45 M)
نوع مقاله: Case report
شناسه دیجیتال (DOI): 10.22038/aojnmb.2023.73477.1512
نویسندگان
Kodai Kawaji* 1؛ Seiji Kurata2؛ Katsuhisa Matsuo3؛ Hiroaki Miyoshi3؛ Jun Akiba4؛ Fumihiko Mouri5؛ Akiko Sumi2؛ Kiminori Fujimoto2؛ Toshi Abe2
1Department of Radiology, Kagoshima University, Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
2Department of Radiology, Kurume University School of Medicine, Kurume, Japan
3Department of Pathology, Kurume University School of Medicine, Kurume, Japan
4Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan
5Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, Japan
چکیده
18F-FDG PET/CT is regarded as a modality utilized for the purpose of lesion localization, staging and assessment of treatment response in patients with lymphoma. However, it is difficult that we diagnose among multifocal lymphoma, IgG4-related disease (IgG4-RD), or a combination of both conditions when confronted with multiple sites of 18F-FDG uptake with heightened serum IgG4 levels.
We present a case of a 72-year-old male who was suspected of Sjögren’s syndrome based on symptoms of xerostomia accompanied by swelling of the bilateral upper eyelid and salivary glands. Following a diagnostic biopsy that revealed mucosa-associated lymphoid tissue (MALT) lymphoma as a possible finding, 18F-FDG PET/CT was conducted, which demonstrated multiple sites of 18F-FDG accumulation. While multifocal MALT lymphoma was initially suspected, the coexistence of IgG4-RD could not be definitively ruled out due to the elevated serum IgG4 levels. Subsequent histopathological and immunohistochemical examinations confirmed the diagnosis of IgG4-producing MALT lymphoma. After receiving systemic therapy with rituximab, the swelling of the bilateral upper eyelid and parotid glands resolved upon visual examination, and the serum IgG4 levels returned to within the normal range in a few months. No new lesions were detected during the subsequent follow-up examinations conducted over a period of 3 years.
کلیدواژه‌ها
IgG4-producing MALT lymphoma؛ IgG4-related disease؛ 18F-FDG PET/CT؛ Multiple 18F-FDG uptake؛ Plasmacytic differentiation
مراجع
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آمار
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