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Kao, Feng-Chen, Yen, Chia-Ming, Lin, Ming-Chia, Liao, Hsien-Yin, Hsu, Hsin-Cheng, Lin, Yi-Wen. (1402). Acupoint catgut embedding attenuates fibromyalgia pain through attenuation of TRPV1 signaling pathway in mouse. , 27(1), 66-73. doi: 10.22038/ijbms.2023.71431.15534
Feng-Chen Kao; Chia-Ming Yen; Ming-Chia Lin; Hsien-Yin Liao; Hsin-Cheng Hsu; Yi-Wen Lin. "Acupoint catgut embedding attenuates fibromyalgia pain through attenuation of TRPV1 signaling pathway in mouse". , 27, 1, 1402, 66-73. doi: 10.22038/ijbms.2023.71431.15534
Kao, Feng-Chen, Yen, Chia-Ming, Lin, Ming-Chia, Liao, Hsien-Yin, Hsu, Hsin-Cheng, Lin, Yi-Wen. (1402). 'Acupoint catgut embedding attenuates fibromyalgia pain through attenuation of TRPV1 signaling pathway in mouse', , 27(1), pp. 66-73. doi: 10.22038/ijbms.2023.71431.15534
Kao, Feng-Chen, Yen, Chia-Ming, Lin, Ming-Chia, Liao, Hsien-Yin, Hsu, Hsin-Cheng, Lin, Yi-Wen. Acupoint catgut embedding attenuates fibromyalgia pain through attenuation of TRPV1 signaling pathway in mouse. , 1402; 27(1): 66-73. doi: 10.22038/ijbms.2023.71431.15534

Acupoint catgut embedding attenuates fibromyalgia pain through attenuation of TRPV1 signaling pathway in mouse

Iranian Journal of Basic Medical Sciences
مقاله 10، دوره 27، شماره 1، فروردین 2024، صفحه 66-73    اصل مقاله (672.51 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.71431.15534
نویسندگان
Feng-Chen Kao1، 2، 3؛ Chia-Ming Yen4، 5؛ Ming-Chia Lin6؛ Hsien-Yin Liao7؛ Hsin-Cheng Hsu7؛ Yi-Wen Lin* 8، 9
1School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan
2Department of Orthopedics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan
3Department of Orthopedics, E-Da Dachang Hospital, I-Shou University, Kaohsiung, Taiwan
4Department of Anesthesiology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 42743, Taiwan
5School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 97004, Taiwan
6Department of Nuclear Medicine, E-DA Hospital, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
7College of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 40402, Taiwan
8College of Chinese Medicine, Graduate Institute of Acupuncture Science, China Medical University, Taichung 404332, Taiwan
9Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan
چکیده
Objective(s): Chronic pain is considered as pain lasting for more than three months and has emerged as a global health problem affecting individuals and society. Chronic extensive pain is the main syndrome upsetting individuals with fibromyalgia (FM), accompanied by anxiety, obesity, sleep disturbances, and depression, Transient receptor potential vanilloid 1 (TRPV1) has been reported to transduce inflammatory and pain signals to the brain.
Materials and Methods: Acupoint catgut embedding (ACE) is a novel acupuncture technique that provides continuous effects and convenience. ACE was performed at the bilateral ST36 acupoint. 
Results: We demonstrated similar pain levels among all groups at baseline. After cold stress, chronic mechanical or thermal nociception was induced (D14: mechanical: 1.85 ± 0.13 g; thermal: 4.85 ± 0.26 s) and reversed in ACE-treated mice (D14: mechanical: 3.99 ± 0.16 g; thermal: 7.42 ± 0.45 s) as well as Trpv1-/- group (Day 14, mechanical: 4.25 ± 0.2 g; thermal: 7.91 ± 0.21 s) mice. Inflammatory mediators were augmented in FM individuals and were abridged after ACE management and TRPV1 gene loss. TRPV1 and its linked mediators were increased in the thalamus (THA), somatosensory cortex (SSC), medial prefrontal cortex (mPFC), and anterior cingulate cortex (ACC) in FM mice. The up-regulation of these mediators was diminished in ACE and Trpv1-/- groups. 
Conclusion: We suggest that chronic pain can be modulated by ACE or Trpv1-/-. ACE-induced analgesia via TRPV1 signaling pathways may be beneficial targets for FM treatment.
کلیدواژه‌ها
Acupoint catgut embedding؛ Chronic pain؛ Fibromyalgia؛ Somatosensory cortex؛ Thalamus TRPV1
مراجع
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