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Goljanian Tabrizi, Ali, Mohseni Ashjerdi, Maliheh, Ghazizadeh, Matin, Maleki, Majid. (1402). SARS-Cov-2 Cycle Threshold Value and Olfactory Dysfunction in COVID-19 Patients. , 35(5), 263-272. doi: 10.22038/ijorl.2023.71462.3429
Ali Goljanian Tabrizi; Maliheh Mohseni Ashjerdi; Matin Ghazizadeh; Majid Maleki. "SARS-Cov-2 Cycle Threshold Value and Olfactory Dysfunction in COVID-19 Patients". , 35, 5, 1402, 263-272. doi: 10.22038/ijorl.2023.71462.3429
Goljanian Tabrizi, Ali, Mohseni Ashjerdi, Maliheh, Ghazizadeh, Matin, Maleki, Majid. (1402). 'SARS-Cov-2 Cycle Threshold Value and Olfactory Dysfunction in COVID-19 Patients', , 35(5), pp. 263-272. doi: 10.22038/ijorl.2023.71462.3429
Goljanian Tabrizi, Ali, Mohseni Ashjerdi, Maliheh, Ghazizadeh, Matin, Maleki, Majid. SARS-Cov-2 Cycle Threshold Value and Olfactory Dysfunction in COVID-19 Patients. , 1402; 35(5): 263-272. doi: 10.22038/ijorl.2023.71462.3429

SARS-Cov-2 Cycle Threshold Value and Olfactory Dysfunction in COVID-19 Patients

Iranian Journal of Otorhinolaryngology
مقاله 4، دوره 35، شماره 5 - شماره پیاپی 130، آذر و دی 2023، صفحه 263-272    اصل مقاله (656.28 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2023.71462.3429
نویسندگان
Ali Goljanian Tabrizi؛ Maliheh Mohseni Ashjerdi؛ Matin Ghazizadeh* ؛ Majid Maleki
Department of Otolaryngology, Head and Neck Surgery, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.
چکیده
Introduction:
Considering the inconsistent results regarding the association between the severity and duration of olfactory dysfunction (OD), and the viral load in coronavirus disease 2019 (COVID-19) patients, we aimed to conduct this study.
 
Materials and Methods:
This is a prospective cohort study in which COVID-19 patients were evaluated for the initial cycle threshold value (Ct values) measured by the nasopharyngeal samples along with olfactory function measured by the University of Pennsylvania Smell Identification Test (UPSIT) within 2 months of COVID-19 onset.
Results:
Among 309 COVID-19 patients who were included in this study, 108 (34.9%), 112 (36.2%) and 89 (28.8%) were normosmic, hyposmic, and anosmic, respectively based on the UPSIT. The severity of COVID-19 and the rate of hospitalization were higher in anosmic patients (p<0.0001, and p<0.0001, respectively). Moreover, significant associations between the initial Ct value and the severity of OD at admission and follow-ups were detected (p<0.0001 and p<0.0001, respectively). Anosmic patients had higher Ct values in comparison with hyposmic (approx. 3-fold) and normosmic (approx. 12-fold) patients. The recovery rate after one- and two-month follow-ups was 47% and 84%, respectively. At the follow-ups, OD-recovered patients significantly had lower Ct values (mean Ct value: 27.79 ± 2 and 28.21 ± 2.08) in comparison with those who have not recovered yet (mean Ct value: 30.19 ± 3.36, and 33.6 ± 3.37) (p<0.0001, and p<0.0001, respectively).
Conclusions:
Ct value seems to be a significant factor not only in predicting OD severity in COVID-19 patients but also in the OD recovery duration. This finding may be helpful to investigate the underlying mechanisms of OD in COVID-19 patients.
 
کلیدواژه‌ها
COVID-19؛ Cycle threshold value؛ Olfactory impairment؛ SARS-CoV-2 infection؛ Coronavirus disease 2019؛ Olfaction disorders
مراجع
  1. Yazdi M, Bemanalizadeh M, Mohebpour F, Goli P, Daniali SS, Kelishadi R. Latent class analysis of knowledge, attitude, and practice of a population-based sample of Iranian pregnant women toward COVID-19. Advanced Biomedical Research. 2022;11.
  2. Mirmohammadkhani M, Bemanalizadeh M, Yazdi M, Goli P, Mohebpour F, Saffarieh E, et al. Knowledge, attitudes, and practices toward COVID-19 among persian birth cohort participants. Journal of Education and Health Promotion. 2021;10.
  3. Sun P, Qie S, Liu Z, Ren J, Li K, Xi J. Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: a single arm meta‐ Journal of medical virology. 2020;92(6):612-7.
  4. Hopkins C, Kumar N. Loss of sense of smell as marker of COVID-19 infection. The Royal College of Surgeons of England: British Rhinological Society. 2020:1-2.
  5. Hopkins C, Surda P, Kumar N. Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology. 2020;58(3):295-8.
  6. Eliezer M, Hautefort C, Hamel A-L, Verillaud B, Herman P, Houdart E, et al. Sudden and complete olfactory loss of function as a possible symptom of COVID-19. JAMA otolaryngology–head & neck surgery. 2020;146(7):674-5.
  7. Xydakis MS, Dehgani-Mobaraki P, Holbrook EH, Geisthoff UW, Bauer C, Hautefort C, et al. Smell and taste dysfunction in patients with COVID-19. The Lancet Infectious Diseases. 2020;20(9):1015-6.
  8. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. European Archives of Oto-rhino-laryngology. 2020; 277(8):2251-61.
  9. Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases. Head & neck. 2020;42(6):1252-8.
  10. Yan CH, Faraji F, Prajapati DP, Boone CE, DeConde AS. Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. International forum of allergy & rhinology. 2020;10(7):806-13.
  11. Surgery AAoOHaN. Anosmia, hyposmia, and dysgeusia symptoms of coronavirus disease 2020 [updated March 22, 2020. Available from: https://www.entnet.org/content/aao-hns-anosmia-hyposmia-anddysgeusia-symptoms-coronavirus-disease.
  12. Petrocelli M, Ruggiero F, Baietti AM, Pandolfi P, Salzano G, Salzano FA, et al. Remote psychophysical evaluation of olfactory and gustatory functions in early-stage coronavirus disease 2019 patients: the Bologna experience of 300 cases. The Journal of laryngology and otology. 2020;134(7):571-6.
  13. Parma V, Ohla K, Veldhuizen MG, Niv MY, Kelly CE, Bakke AJ, et al. More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis. Chemical senses. 2020;45(7):609-22.
  14. Vaira LA, Lechien JR, Khalife M, Petrocelli M, Hans S, Distinguin L, et al. Psychophysical Evaluation of the Olfactory Function: European Multicenter Study on 774 COVID-19 Patients. Pathogens (Basel, Switzerland). 2021;10(1).
  15. Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C, et al. Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. Jama. 2020; 323(20):
    2089-90.
  16. Sedaghat AR, Gengler I, Speth MM. Olfactory Dysfunction: A Highly Prevalent Symptom of COVID-19 With Public Health Significance. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2020;163(1):12-5.
  17. Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. International forum of allergy & rhinology. 2020; 10(8):944-50.
  18. Wölfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Müller MA, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020;581(7809):465-9.
  19. Joynt GM, Wu WK. Understanding COVID-19: what does viral RNA load really mean? The Lancet Infectious diseases. 2020;20(6):635-6.
  20. Yu X, Sun S, Shi Y, Wang H, Zhao R, Sheng J. SARS-CoV-2 viral load in sputum correlates with risk of COVID-19 progression. Critical care (London, England). 2020;24(1):170.
  21. Liu Y, Liao W, Wan L, Xiang T, Zhang W. Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. Viral immunology. 2021;34(5):330-5.
  22. Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. The New England journal of medicine. 2020;382(12):1177-9.
  23. Cho RHW, To ZWH, Yeung ZWC, Tso EYK, Fung KSC, Chau SKY, et al. COVID-19 Viral Load in the Severity of and Recovery From Olfactory and Gustatory Dysfunction. The Laryngoscope. 2020;130(11):2680-5.
  24. Vaira LA, Deiana G, Lechien JR, De Vito A, Cossu A, Dettori M, et al. Correlations Between Olfactory Psychophysical Scores and SARS-CoV-2 Viral Load in COVID-19 Patients. The Laryngoscope. 2021;131(10):2312-8.
  25. Lechien JR, Chiesa-Estomba CM, Hans S, Calvo-Henriquez C, Mayo-Yáñez M, Tucciarone M, et al. Validity and reliability of the COVID-19 symptom index, an instrument evaluating severity of general and otolaryngological symptoms. Acta oto-laryngologica. 2021;141(6):615-20.
  26. Moein ST, Hashemian SM, Tabarsi P, Doty RL. Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID-19 patients. International forum of allergy & rhinology. 2020;10(10):1127-35.
  27. Doty RL, Shaman P, Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiology & behavior. 1984;32(3):489-502.
  28. Vaira LA, Salzano G, Fois AG, Piombino P, De Riu G. Potential pathogenesis of ageusia and anosmia in COVID-19 patients. International forum of allergy & rhinology. 2020;10(9):1103-4.
  29. Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T, et al. COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron. 2020;107(2):219-33.
  30. Han AY, Mukdad L, Long JL, Lopez IA. Anosmia in COVID-19: Mechanisms and Significance. Chemical senses. 2020.
  31. Chigr F, Merzouki M, Najimi M. Autonomic Brain Centers and Pathophysiology of COVID-19. ACS chemical neuroscience. 2020;11(11):1520-2.
  32. Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Soma D, Giovanditto F, et al. Do olfactory and gustatory psychophysical scores have prognostic value in COVID-19 patients? A prospective study of 106 patients. Journal of Otolaryngology - Head & Neck Surgery. 2020;49(1):56.
  33. Speth MM, Singer-Cornelius T, Oberle M, Gengler I, Brockmeier SJ, Sedaghat AR. Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2020;163(1):114-20.
  34. Lechien JR, Ducarme M, Place S, Chiesa-Estomba CM, Khalife M, De Riu G, et al. Objective Olfactory Findings in Hospitalized Severe COVID-19 Patients. Pathogens (Basel, Switzerland). 2020;9(8).
  35. Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Chiesa-Estomba CM, Salzano G, et al. Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study. The Journal of laryngology and otology. 2020;134(8):703-9.
  36. Lechien JR, Michel J, Radulesco T, Chiesa-Estomba CM, Vaira LA, De Riu G, et al. Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report. The Laryngoscope. 2020;130(11):2526-31.
  37. Eliezer M, Hautefort C. MRI Evaluation of the Olfactory Clefts in Patients with SARS-CoV-2 Infection Revealed an Unexpected Mechanism for Olfactory Function Loss. Academic radiology. 2020;27(8):1191.
  38. Lechien JR, Radulesco T, Calvo-Henriquez C, Chiesa-Estomba CM, Hans S, Barillari MR, et al. ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review. Head and neck pathology. 2021;15(1):225-35.
  39. Brann DH, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B, et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Science advances. 2020;6(31).
  40. Vaira LA, Hopkins C, Sandison A, Manca A, Machouchas N, Turilli D, et al. Olfactory epithelium histopathological findings in long-term coronavirus disease 2019 related anosmia. The Journal of laryngology and otology. 2020;134(12):1123-7.
  41. Kirschenbaum D, Imbach LL, Ulrich S, Rushing EJ, Keller E, Reimann RR, et al. Inflammatory olfactory neuropathy in two patients with COVID-19. Lancet (London, England). 2020;396(10245):166.
  42. Boscolo-Rizzo P, Menegaldo A, Fabbris C, Spinato G, Borsetto D, Vaira LA, et al. Six-Month Psychophysical Evaluation of Olfactory Dysfunction in Patients with COVID-19. Chemical senses. 2021;46.
  43. Niklassen AS, Draf J, Huart C, Hintschich C, Bocksberger S, Trecca EMC, et al. COVID-19: Recovery from Chemosensory Dysfunction. A Multicentre study on Smell and Taste. The Laryngoscope. 2021;131(5):1095-100.
  44. Petrocelli M, Cutrupi S, Salzano G, Maglitto F, Salzano FA, Lechien JR, et al. Six-month smell and taste recovery rates in coronavirus disease 2019 patients: a prospective psychophysical study. The Journal of laryngology and otology. 2021;135(5):436-41.
  45. Hopkins C, Surda P, Vaira LA, Lechien JR, Safarian M, Saussez S, et al. Six month follow-up of self-reported loss of smell during the COVID-19 pandemic. Rhinology. 2021;59(1):26-31.
  46. Lechien JR, Chiesa-Estomba CM, Vaira LA, De Riu G, Cammaroto G, Chekkoury-Idrissi Y, et al. Epidemiological, otolaryngological, olfactory and gustatory outcomes according to the severity of COVID-19: a study of 2579 patients. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2021;278(8):2851-9.
  47. Vaira LA, De Vito A, Deiana G, Pes C, Giovanditto F, Fiore V, et al. Correlations between IL-6 serum level and olfactory dysfunction severity in COVID-19 patients: a preliminary study. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2022;279(2):811-6.
  48. Saussez S, Sharma S, Thiriard A, Olislagers V, Vu Duc I, Le Bon SD, et al. Predictive factors of smell recovery in a clinical series of 288 coronavirus disease 2019 patients with olfactory dysfunction. European journal of neurology. 2021;28(11):3702-11.
  49. Jain A, Pandey AK, Kaur J, Kumar L, Singh M, Das S, et al. Is there a correlation between viral load and olfactory & taste dysfunction in COVID-19 patients? American journal of otolaryngology. 2021;42(3):102911.
  50. Taziki Balajelini MH, Rajabi A, Mohammadi M, Nikoo HR, Tabarraei A, Mansouri M, et al. Virus load and incidence of olfactory, gustatory, respiratory, gastrointestinal disorders in COVID-19 patients: A retrospective cohort study. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery. 2021;46(6):1331-8.
  51. Hannum ME, Ramirez VA, Lipson SJ, Herriman RD, Toskala AK, Lin C, et al. Objective sensory testing methods reveal a higher prevalence of olfactory loss in COVID-19 positive patients compared to subjective methods: A systematic review and meta-analysis. medRxiv : the preprint server for health sciences. 2020.
  52. Mazzatenta A, Neri G, D'Ardes D, De Luca C, Marinari S, Porreca E, et al. Smell and Taste in Severe CoViD-19: Self-Reported vs. Testing. Frontiers in medicine. 2020;7:589409.
  53. Kucirka LM, Lauer SA, Laeyendecker O, Boon D, Lessler J. Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure. Annals of internal medicine. 2020;173(4):262-7.
  54. Dahdouh E, Lázaro-Perona F, Romero-Gómez MP, Mingorance J, García-Rodriguez J. C(t) values from SARS-CoV-2 diagnostic PCR assays should not be used as direct estimates of viral load. The Journal of infection. 2021;82(3):414-51.
  55. Rhoads D, Peaper DR, She RC, Nolte FS, Wojewoda CM, Anderson NW, et al. College of American Pathologists (CAP) Microbiology Committee Perspective: Caution Must Be Used in Interpreting the Cycle Threshold (Ct) Value. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021;72(10):e685-e6.
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