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Moayedi, Sedigheh, Khademi, Bijan, Malekzadeh, Mahyar, Farzinnia, Golnoush, Jaafari-Ashkavandi, Zohreh. (1402). Serum Level of Vitamin D in Patients with Salivary Gland Tumors. , 35(5), 273-278. doi: 10.22038/ijorl.2023.69088.3346
Sedigheh Moayedi; Bijan Khademi; Mahyar Malekzadeh; Golnoush Farzinnia; Zohreh Jaafari-Ashkavandi. "Serum Level of Vitamin D in Patients with Salivary Gland Tumors". , 35, 5, 1402, 273-278. doi: 10.22038/ijorl.2023.69088.3346
Moayedi, Sedigheh, Khademi, Bijan, Malekzadeh, Mahyar, Farzinnia, Golnoush, Jaafari-Ashkavandi, Zohreh. (1402). 'Serum Level of Vitamin D in Patients with Salivary Gland Tumors', , 35(5), pp. 273-278. doi: 10.22038/ijorl.2023.69088.3346
Moayedi, Sedigheh, Khademi, Bijan, Malekzadeh, Mahyar, Farzinnia, Golnoush, Jaafari-Ashkavandi, Zohreh. Serum Level of Vitamin D in Patients with Salivary Gland Tumors. , 1402; 35(5): 273-278. doi: 10.22038/ijorl.2023.69088.3346

Serum Level of Vitamin D in Patients with Salivary Gland Tumors

Iranian Journal of Otorhinolaryngology
مقاله 5، دوره 35، شماره 5 - شماره پیاپی 130، آذر و دی 2023، صفحه 273-278    اصل مقاله (585.05 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2023.69088.3346
نویسندگان
Sedigheh Moayedi1؛ Bijan Khademi2؛ Mahyar Malekzadeh3؛ Golnoush Farzinnia4؛ Zohreh Jaafari-Ashkavandi* 5
1Department of Orthodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
2Otolaryngology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
4Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
5Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Introduction:

The active vitamin D metabolites have anticancer effects on many human neoplasms. The vitamin D receptors have been detected in salivary glands tissue. This study aimed to evaluate the serum level of vitamin D in patients with malignant and benign salivary gland tumors.

Materials and Methods:

In this retrospective and cross-sectional study, 151 participants, including 42 patients with benign, 42 malignant salivary gland tumors, and 67 healthy subjects, participated. The serum level of vitamin D was measured using an enzyme-linked immunosorbent assay (ELISA).

Results:

The mean serum level of vitamin D was 42.7 ng/mL in patients with benign tumors, 40 ng/mL in malignant tumors, and 36.7 ng/mL in the control group. There was no significant difference between the mean vitamin D level and vitamin D status in patients with salivary gland tumors and normal controls (P=0.2). There was a significant positive correlation between vitamin D level and age in the control group (P=0.04).

Conclusions:

The results showed a high prevalence rate of vitamin D deficiency/insufficiency in salivary gland tumors and normal subjects, with no significant difference. Therefore, the serum level of vitamin D might not play a significant role in the pathogenesis of these tumors, similar to many human cancers. However, further prospective studies are recommended focusing on specific tumors and considering other interventional factors.
کلیدواژه‌ها
Cancer؛ Mucoepidermoid carcinoma؛ Pleomorphic adenoma؛ Salivary gland؛ Vitamin D
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