سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Hemat Jouy, Shaghayegh, Shahraki, Jafar, Rezaee, Ramin, Ghorani, Vahideh, Gholami, Mandana. (1402). Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats. , 14(2), 177-188. doi: 10.22038/ajp.2023.22937
Shaghayegh Hemat Jouy; Jafar Shahraki; Ramin Rezaee; Vahideh Ghorani; Mandana Gholami. "Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats". , 14, 2, 1402, 177-188. doi: 10.22038/ajp.2023.22937
Hemat Jouy, Shaghayegh, Shahraki, Jafar, Rezaee, Ramin, Ghorani, Vahideh, Gholami, Mandana. (1402). 'Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats', , 14(2), pp. 177-188. doi: 10.22038/ajp.2023.22937
Hemat Jouy, Shaghayegh, Shahraki, Jafar, Rezaee, Ramin, Ghorani, Vahideh, Gholami, Mandana. Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats. , 1402; 14(2): 177-188. doi: 10.22038/ajp.2023.22937

Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats

Avicenna Journal of Phytomedicine
دوره 14، شماره 2، خرداد و تیر 2024، صفحه 177-188    اصل مقاله (794.29 K)
نوع مقاله: Short communication
شناسه دیجیتال (DOI): 10.22038/ajp.2023.22937
نویسندگان
Shaghayegh Hemat Jouy1؛ Jafar Shahraki2؛ Ramin Rezaee3؛ Vahideh Ghorani* 4؛ Mandana Gholami* 5
1Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
3International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Clinical Research Development Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
Objective: The present study examined effects of resistance training (RT) and resveratrol (RES) alone and together on acrylamide (AC)-induced memory impairment in rats.
Materials and Methods: Animals were divided into 6 groups: (1) Control group which received normal saline intraperitoneally (ip) daily for 8 weeks; (2) Scopolamine (SCO) group which received SCO (1 mg/kg/day, ip) for 8 weeks; (3) AC group which received AC (5 mg/kg/day, ip) for 8 weeks; (4) AC + RT group which received AC (5 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks); (5) AC + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks; and (6) AC + RT + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks). On day 53, animal training began in the Morris Water Maze (MWM) and 24 hr after the last training, the probe test was performed.
Results: RT and RES alone did not significantly affect escape latency or traveled distance increased by AC. However, concomitant RES and RT treatment significantly reduced these parameters compared to the AC group. Co-treatment with RES and RT also significantly increased the time spent in the target quadrant compared to the AC group. Lipid peroxidation was reduced in the AC+RES and AC+RT+RES groups compared to the AC group. 
Conclusion: It seems that daily co-treatment with RES and RT for 8 weeks ameliorates the memory-impairing effects of AC.
کلیدواژه‌ها
Acrylamide؛ Resveratrol؛ Scopolamine؛ Resistance training؛ Spatial memory
آمار
تعداد مشاهده مقاله: 30,569
تعداد دریافت فایل اصل مقاله: 61,752