سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Karimi, Amin, Ebrahimpour, Adel, Sadighi, Mehrdad, Chehrassan, Mohammadreza, Biglari, Farsad, Jafari Kafiabadi, Meisam, Azizmohammad Looha, Mehdi, Akbari, Mohammad Esmaeil. (1402). Descriptive Epidemiology and Survival Rate of Osteosarcoma: The First National Population-Based Study in the Middle East (2008-2014). , 11(10), 649-657. doi: 10.22038/abjs.2023.59676.2945
Amin Karimi; Adel Ebrahimpour; Mehrdad Sadighi; Mohammadreza Chehrassan; Farsad Biglari; Meisam Jafari Kafiabadi; Mehdi Azizmohammad Looha; Mohammad Esmaeil Akbari. "Descriptive Epidemiology and Survival Rate of Osteosarcoma: The First National Population-Based Study in the Middle East (2008-2014)". , 11, 10, 1402, 649-657. doi: 10.22038/abjs.2023.59676.2945
Karimi, Amin, Ebrahimpour, Adel, Sadighi, Mehrdad, Chehrassan, Mohammadreza, Biglari, Farsad, Jafari Kafiabadi, Meisam, Azizmohammad Looha, Mehdi, Akbari, Mohammad Esmaeil. (1402). 'Descriptive Epidemiology and Survival Rate of Osteosarcoma: The First National Population-Based Study in the Middle East (2008-2014)', , 11(10), pp. 649-657. doi: 10.22038/abjs.2023.59676.2945
Karimi, Amin, Ebrahimpour, Adel, Sadighi, Mehrdad, Chehrassan, Mohammadreza, Biglari, Farsad, Jafari Kafiabadi, Meisam, Azizmohammad Looha, Mehdi, Akbari, Mohammad Esmaeil. Descriptive Epidemiology and Survival Rate of Osteosarcoma: The First National Population-Based Study in the Middle East (2008-2014). , 1402; 11(10): 649-657. doi: 10.22038/abjs.2023.59676.2945

Descriptive Epidemiology and Survival Rate of Osteosarcoma: The First National Population-Based Study in the Middle East (2008-2014)

The Archives of Bone and Joint Surgery
مقاله 7، دوره 11، شماره 10، دی 2023، صفحه 649-657    اصل مقاله (1.01 M)
نوع مقاله: RESEARCH PAPER
شناسه دیجیتال (DOI): 10.22038/abjs.2023.59676.2945
نویسندگان
Amin Karimi1؛ Adel Ebrahimpour* 2؛ Mehrdad Sadighi2؛ Mohammadreza Chehrassan3؛ Farsad Biglari2؛ Meisam Jafari Kafiabadi4؛ Mehdi Azizmohammad Looha4؛ Mohammad Esmaeil Akbari4
11 Department of orthopedics, Taleghani Hospital Research Development committee, Shahid Beheshti University of medical sciences, Tehran, Iran 2 Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
2Department of Orthopedic Surgery, Clinical Research Development Unit of Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Bone and Joint reconstruction research center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran
4Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Objectives: The epidemiology of osteosarcoma (OS), the most common primary bone sarcoma, was not 
evaluated in the Middle East. Therefore, this study aimed to examine the incidence, demographic 
characteristics, epidemiology, and survival rate of patients with different subtypes of OS, based on data 
derived from the Iran National Cancer Registry (INCR) to evaluate the influence of ethnicity and race.
Methods: All OS patients registered in the INCR between March 20, 2008, and March 20, 2014, were enrolled in 
this study, and information such as age, gender, cancer location, OS subtype, and survival time were evaluated 
statistically.
Results: The Age-Standardized Incidence Rate (ASIR) for OS was 3.02 per million person-years, with a mean age 
of 25.6 years and a male-female ratio of 1.54:1. Not Otherwise Specified (NOS) OS, chondroblastic OS, and central 
OS had the highest frequencies among the subtypes of OS. The overall one-, three-, and five-year survival rates 
were 87%, 61%, and 49%, respectively, with a mean duration of 6.16 years.
Conclusion: The ASIR of OS in our country was similar to that in the US and higher than that in China. The peak 
frequency was between 15-19 years old. The male-female ratio in our patients was higher than the OS gender ratio 
in most series. Although it was not statistically significant, older age at the time of diagnosis, axial location, and male 
gender were the poorest prognosis factors.
 Level of evidence: III
کلیدواژه‌ها
Bone cancer؛ Epidemiology Incidence؛ Osteosarcoma؛ Survival
مراجع
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  2. Dorfman HD, Czerniak B. Bone cancers. Cancer. 1995; 75(1 Suppl):203-210. doi: 10.1002/1097-0142(19950101)75:1+<203::aid-cncr2820751308>3.0.co;2-v.
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  4. Campanacci M. Bone and soft tissue tumors: clinical features, imaging, pathology and treatment. Springer Science & Business Media; 2013.
  5. Damron TA, Ward WG, Stewart A. Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. Clin Orthop Relat Res. 2007; 459:40-47. doi:10.1097/BLO.0b013e318059b8c9.
  6. Anfinsen KP, Devesa SS, Bray F, et al. Age-period-cohort analysis of primary bone cancer incidence rates in the United States (1976-2005). Cancer Epidemiol Biomarkers Prev. 2011; 20(8):1770-1777. doi:10.1158/1055-9965.EPI-11-0136.
  7. Hayden JB, Hoang BH. Osteosarcoma: basic science and clinical implications. Orthop Clin North Am. 2006;37(1):1-7. doi:10.1016/j.ocl.2005.06.004.
  8. Pingping B, Yuhong Z, Weiqi L, et al. Incidence and Mortality of Sarcomas in Shanghai, China, During 2002-2014. Front Oncol. 2019;9:662.doi:10.3389/fonc.2019.00662.
  9. Duchman KR, Gao Y, Miller BJ. Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) Program database. Cancer Epidemiol. 2015; 39(4):593-599. doi:10.1016/j.canep.2015.05.001.
  10. Mialou V, Philip T, Kalifa C, et al. Metastatic osteosarcoma at diagnosis: prognostic factors and long-term outcome--the French pediatric experience. Cancer. 2005; 104(5):1100-1109. doi:10.1002/cncr.21263.
  11. Akbari A, Khayamzadeh M, Salmanian R, et al. International Journal of Cancer Management. National cancer mortality-to-incidence ratio (MIR) in Iran (2005-2014). 2019; 12(6). doi.org/10.5812/ijcm.94145.
  12. Trott PA. International classification of diseases for oncology. Journal of clinical pathology. 1977;30(8):782.
  13. Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M. Age standardization of rates: a new WHO standard. Geneva: World Health Organization. 2001; 9(10):1-4.
  14. Boyle P, Parkin DM. Cancer registration: principles and methods. Statistical methods for registries. IARC Sci Publ. 1991 ;( 95):126-158.
  15. Duong LM, Richardson LC. Descriptive epidemiology of malignant primary osteosarcoma using population-based registries, United States, 1999-2008. J Registry Manag. 2013; 40(2):59-64.
  16. Whelan J, McTiernan A, Cooper N, et al. Incidence and survival of malignant bone sarcomas in England 1979-2007. Int J Cancer. 2012; 131(4):E508-E517. doi:10.1002/ijc.26426.
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