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Saheb, Mahsa, Khodadadegan, Mohammad Amin, Sahab Negah, Sajad, Saburi, Ehsan, Hajali, Vahid. (1402). Effect of a combined program of running exercise and environmental enrichment on memory function and neurogenesis markers in amyloid-beta-induced Alzheimer-like model. , 26(12), 1400-1408. doi: 10.22038/ijbms.2023.70269.15277
Mahsa Saheb; Mohammad Amin Khodadadegan; Sajad Sahab Negah; Ehsan Saburi; Vahid Hajali. "Effect of a combined program of running exercise and environmental enrichment on memory function and neurogenesis markers in amyloid-beta-induced Alzheimer-like model". , 26, 12, 1402, 1400-1408. doi: 10.22038/ijbms.2023.70269.15277
Saheb, Mahsa, Khodadadegan, Mohammad Amin, Sahab Negah, Sajad, Saburi, Ehsan, Hajali, Vahid. (1402). 'Effect of a combined program of running exercise and environmental enrichment on memory function and neurogenesis markers in amyloid-beta-induced Alzheimer-like model', , 26(12), pp. 1400-1408. doi: 10.22038/ijbms.2023.70269.15277
Saheb, Mahsa, Khodadadegan, Mohammad Amin, Sahab Negah, Sajad, Saburi, Ehsan, Hajali, Vahid. Effect of a combined program of running exercise and environmental enrichment on memory function and neurogenesis markers in amyloid-beta-induced Alzheimer-like model. , 1402; 26(12): 1400-1408. doi: 10.22038/ijbms.2023.70269.15277

Effect of a combined program of running exercise and environmental enrichment on memory function and neurogenesis markers in amyloid-beta-induced Alzheimer-like model

Iranian Journal of Basic Medical Sciences
مقاله 3، دوره 26، شماره 12، اسفند 2023، صفحه 1400-1408    اصل مقاله (799.32 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.70269.15277
نویسندگان
Mahsa Saheb1؛ Mohammad Amin Khodadadegan2؛ Sajad Sahab Negah1، 3؛ Ehsan Saburi4؛ Vahid Hajali* 1
1Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences Mashhad, Iran
3Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Medical Genetics and Molecular Medicine Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): It is urgent to develop non-pharmacological interventions or multifactor combination approaches to combat Alzheimer’s disease (AD). The effect of exercise (EX) combined with environmental enrichment (EE) on behavioral phenotypes and neurogenesis markers in an Alzheimer-like rat model was investigated. 
Materials and Methods: The groups consisted of AD, sham-operated, AD+EX, AD+EE, and AD+EX+EE. AD was produced by injection of amyloid-beta (1-42, 6 µg) intrahippocampally, and a daily treadmill for 3 consecutive weeks was used for EX animals. EE was a large cage (50× 50× 50 cm) containing differently shaped objects. Spatial learning and memory were evaluated in the Morris water maze (MWM), and a shuttle box was used to evaluate inhibitory avoidance memory. RT-PCR was performed to assess the expression of early neurogenesis markers, DCX, and Sox2 within the hippocampus.
Results: Pretreatment with exercise and EE, both individually and in combination, could provide protection from memory impairments in AD rats. Combined treatment led to a significantly more pronounced improvement in memory deficits of AD rats than either paradigm alone. Combination therapy with exercise and EE could also reverse the passive avoidance memory impairment and hippocampal DCX expression of AD rats to the control levels.
Conclusion: These data suggest that exercise in combination with cognitive engagement can provide a non-pharmacological and multidomain policy that may prevent or delay AD symptoms.
کلیدواژه‌ها
Alzheimer’s؛ Combination effect؛ Environmental enrichment؛ Exercise؛ Neurogenesis؛ Spatial memory
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