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Zhang, Yada, Chen, Yiren, Wu, Yingen, Yang, Ling, Fang, Hong, Cheng, Yanqi, Wu, Yuqin, Tang, Binqing. (1402). Scorpio and centipede ameliorate asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells. , 26(12), 1438-1443. doi: 10.22038/ijbms.2023.70411.15306
Yada Zhang; Yiren Chen; Yingen Wu; Ling Yang; Hong Fang; Yanqi Cheng; Yuqin Wu; Binqing Tang. "Scorpio and centipede ameliorate asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells". , 26, 12, 1402, 1438-1443. doi: 10.22038/ijbms.2023.70411.15306
Zhang, Yada, Chen, Yiren, Wu, Yingen, Yang, Ling, Fang, Hong, Cheng, Yanqi, Wu, Yuqin, Tang, Binqing. (1402). 'Scorpio and centipede ameliorate asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells', , 26(12), pp. 1438-1443. doi: 10.22038/ijbms.2023.70411.15306
Zhang, Yada, Chen, Yiren, Wu, Yingen, Yang, Ling, Fang, Hong, Cheng, Yanqi, Wu, Yuqin, Tang, Binqing. Scorpio and centipede ameliorate asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells. , 1402; 26(12): 1438-1443. doi: 10.22038/ijbms.2023.70411.15306

Scorpio and centipede ameliorate asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells

Iranian Journal of Basic Medical Sciences
مقاله 8، دوره 26، شماره 12، اسفند 2023، صفحه 1438-1443    اصل مقاله (393.81 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.70411.15306
نویسندگان
Yada Zhang1؛ Yiren Chen1؛ Yingen Wu2؛ Ling Yang3؛ Hong Fang4؛ Yanqi Cheng4؛ Yuqin Wu4؛ Binqing Tang* 1
1Department of Respiratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2Department of Internal Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
3Department of Geriatrics, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, China
4Prevention and Health Care Department of TCM, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
چکیده
Objective(s):  We previously revealed that scorpio and centipede (SC) improve the inflammatory response in asthma, whereas it is unclear whether ferroptosis is involved in this process.
Materials and Methods: The asthmatic mouse model was established and lung tissues were collected for histopathological examination. The levels of tumor necrosis factor-α (TNF-α), interleukin- (IL-)1β, Fe2+, malondialdehyde (MDA), glutathione peroxidase 4 (GPX4), ferritin heavy chain 1(FTH1), and reactive oxygen species (ROS) were assessed in asthmatic mice and mouse airway epithelial cells.
Results: Our results showed that ferroptosis was induced in asthmatic mice, as evidenced by the reduction of FTH1 and GPX4 expression and the increase of MDA and Fe2+ levels (all P<0.05). Ferrostatin-1 repressed inflammation and ferroptosis of asthmatic mice. Additionally, SC significantly inhibited the levels of TNF-α, IL-1β, MDA, and Fe2+, while enhancing FTH1 and GPX4 expression. However, SC plus erastin showed the reverse results. Moreover, ferroptosis remarkably increased in asthmatic airway epithelial cells, while SC suppressed ferroptosis of the cells (all P<0.05).
Conclusion: SC ameliorated asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells.
کلیدواژه‌ها
Airway epithelial cells؛ Asthma؛ Ferroptosis؛ Inflammation؛ Scorpio and centipede
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