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Ravanshad, Sahar, Fahimian, Zahra, Shoghi, Parsa, Moradi, Ali, Alizadeh, Valareza, Javdan, Negar, Mehrad-Majd, Hassan. (1402). Prognostic Factors and Survival Outcomes by Disease Subtypes in a Cohort of Iranian Patients with acute leukemia. , 10(2), 38-42. doi: 10.22038/rcm.2023.22798
Sahar Ravanshad; Zahra Fahimian; Parsa Shoghi; Ali Moradi; Valareza Alizadeh; Negar Javdan; Hassan Mehrad-Majd. "Prognostic Factors and Survival Outcomes by Disease Subtypes in a Cohort of Iranian Patients with acute leukemia". , 10, 2, 1402, 38-42. doi: 10.22038/rcm.2023.22798
Ravanshad, Sahar, Fahimian, Zahra, Shoghi, Parsa, Moradi, Ali, Alizadeh, Valareza, Javdan, Negar, Mehrad-Majd, Hassan. (1402). 'Prognostic Factors and Survival Outcomes by Disease Subtypes in a Cohort of Iranian Patients with acute leukemia', , 10(2), pp. 38-42. doi: 10.22038/rcm.2023.22798
Ravanshad, Sahar, Fahimian, Zahra, Shoghi, Parsa, Moradi, Ali, Alizadeh, Valareza, Javdan, Negar, Mehrad-Majd, Hassan. Prognostic Factors and Survival Outcomes by Disease Subtypes in a Cohort of Iranian Patients with acute leukemia. , 1402; 10(2): 38-42. doi: 10.22038/rcm.2023.22798

Prognostic Factors and Survival Outcomes by Disease Subtypes in a Cohort of Iranian Patients with acute leukemia

Reviews in Clinical Medicine
دوره 10، شماره 2، شهریور 2023، صفحه 38-42    اصل مقاله (308.35 K)
نوع مقاله: Original article
شناسه دیجیتال (DOI): 10.22038/rcm.2023.22798
نویسندگان
Sahar Ravanshad1؛ Zahra Fahimian2؛ Parsa Shoghi3؛ Ali Moradi4؛ Valareza Alizadeh3؛ Negar Javdan3؛ Hassan Mehrad-Majd* 5
1Department of internal medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Student Research Committee, Islamic Azad University, Mashhad Branch, Mashhad, Iran
4Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Introduction: Studying the survival factors of leukemia patients can lead to a reduction in healthcare costs. This study aimed to evaluate the survival rate and potential predictive factors in leukemia patients in northeast Iran.
Methods: Baseline demographic and clinical data of patients referred to Ghaem Hospital between 2014 and 2019 were extracted from their medical records. The survival rates were determined by gathering information from phone calls or archived files.
Results: This cohort study consisted of 302 patients with a mean age of 41.09±19.09 years. Among them, 127 (43.3%) had acute lymphoid leukemia, while 166 (56.7%) had myeloid leukemia. The mean overall survival time for all patients was 50.81 months. However, the mean overall survival time for patients with lymphoid leukemia (61.7 months) was significantly higher (P<0.001) than that for patients with myeloid leukemia (41.1 months). Moreover, lymphoid patients had significantly higher one-month and one-year survival rates (93% and 72.8%) than the myeloid group (81% and 53.7%) (P=0.002 and P=0.001). However, significant difference did not exist in the five-year survival rate between the lymphoid and myeloid groups (26.2% vs 18.2%, P=0.174). Cox regression analysis indicated that patient survival was correlated with the type of leukemia (1.45, 95%CI=1.10-8.92, P=0.011), age, hemoglobin levels, as well as WBC, RBC, neutrophil, and platelet count.
Conclusion:Our findings indicated that patients with lymphoid leukemia exhibited a higher survival rate than those with myeloid leukemia. Survival outcomes were dependent on patient’s age, leukemia type, and levels of WBC, RBC, neutrophil, platelet, and hemoglobin levels.
کلیدواژه‌ها
Acute leukemia؛ Survival؛ Lymphoid؛ Myeloid
آمار
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