سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Nazari, Zahra, Bahrehbar, Khadijeh, Ghafari, Soraya, Golalipour, Mohammad Jafar. (1402). Gestational diabetes mellitus increased the number of dopaminergic neurons in the olfactory bulb of rat offspring. , 26(12), 1484-1489. doi: 10.22038/ijbms.2023.71300.15488
Zahra Nazari; Khadijeh Bahrehbar; Soraya Ghafari; Mohammad Jafar Golalipour. "Gestational diabetes mellitus increased the number of dopaminergic neurons in the olfactory bulb of rat offspring". , 26, 12, 1402, 1484-1489. doi: 10.22038/ijbms.2023.71300.15488
Nazari, Zahra, Bahrehbar, Khadijeh, Ghafari, Soraya, Golalipour, Mohammad Jafar. (1402). 'Gestational diabetes mellitus increased the number of dopaminergic neurons in the olfactory bulb of rat offspring', , 26(12), pp. 1484-1489. doi: 10.22038/ijbms.2023.71300.15488
Nazari, Zahra, Bahrehbar, Khadijeh, Ghafari, Soraya, Golalipour, Mohammad Jafar. Gestational diabetes mellitus increased the number of dopaminergic neurons in the olfactory bulb of rat offspring. , 1402; 26(12): 1484-1489. doi: 10.22038/ijbms.2023.71300.15488

Gestational diabetes mellitus increased the number of dopaminergic neurons in the olfactory bulb of rat offspring

Iranian Journal of Basic Medical Sciences
مقاله 14، دوره 26، شماره 12، اسفند 2023، صفحه 1484-1489    اصل مقاله (402.85 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.71300.15488
نویسندگان
Zahra Nazari* 1؛ Khadijeh Bahrehbar2، 3؛ Soraya Ghafari4؛ Mohammad Jafar Golalipour4
1Department of Biology, Faculty of Sciences, Golestan University, Gorgan, Iran
2Department of Biology, Faculty of Basic Sciences, Yasuj University, Yasuj, Iran
3Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
4Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
چکیده
Objective(s): Gestational Diabetes Mellitus (GDM) is the most common metabolic complication of pregnancy that causes central nervous system and olfactory dysfunction in the offspring. It has been demonstrated that dopamine modulates several aspects of olfactory information processing in vertebrates.  
Materials and Methods: In this study, we investigated the effect of gestational diabetes on the expression of the Dopamine (DA) metabolism genes, tyrosine hydroxylase (TH), and dopa decarboxylase (DDC) in the olfactory bulb (OB) tissue of rats’ offspring. Female Wistar rats were divided into a control group which received citrate buffer and the diabetic group which received 45 mg/kg of streptozotocin (STZ) on day 0 of gestation. Fasting blood glucose levels were measured before and 72 hr after injection. OB tissues of adult offspring were isolated, and TH-positive cells were counted by immunofluorescence staining. Also, TH and DDC expressions were analyzed by qRT- PCR and western blot.
Results: The data showed that gestational diabetes could cause up-regulation of TH (P<0.01) and DDC (P<0.05) in the OB tissue of offspring. Furthermore, our results showed that GDM causes a significant increase in TH and DDC protein levels in the OB tissues of offspring. Immunohistochemistry showed a significant increase in the number of TH-positive cells in the offspring of diabetic mothers (P<0.05).
Conclusion: This study showed that gestational diabetes could cause an increase in TH and DDC gene expression in the OB tissue in the offspring, which may be correlated with reduced olfactory sensitivity.
کلیدواژه‌ها
Dopaminergic neurons؛ Gestational diabetes؛ Olfactory bulb؛ Streptozotocin؛ Tyrosine hydroxylase
مراجع
1. Lebed YV, Orlovsky MA, Nikonenko AG, Ushakova GA, Skibo GG. Early reaction of astroglial cells in rat hippocampus to streptozotocin-induced diabetes. Neurosci Lett 2008; 444:181-185.
2. Wang CY, Neil DL, Home P. 2020 vision–An overview of prospects for diabetes management and prevention in the next decade. Diabetes Res Clin Pract 2018; 143:101-112.
3. Care D. Position statements & ADA statements. Diabetes Care 2004; 27:S106-S109.
4. Serlin DC, Lash RW. Diagnosis and management of gestational diabetes mellitus. Am Fam Physician  2009; 80:57-62.
5. Kermani ES, Nazari Z, Mehdizadeh M, Shahbazi M, Golalipour MJ. Gestational diabetes influences the expression of hypertrophic genes in left ventricle of rat’s offspring. Iran J Basic Med Sci 2018; 21:525-528.
6. Nazari Z, Shahryari A, Ghafari S, Nabiuni M, Golalipour MJ. In utero exposure to gestational diabetes alters DNA methylation and gene expression of CDKN2A/B in langerhans islets of rat offspring. Cell J 2020; 22:203-211.
7. Nazari Z, Nabiuni M, Saeidi M, Golalipour MJ. Gestational diabetes leads to down-regulation of CDK4-pRB-E2F1 pathway genes in pancreatic islets of rat offspring. Iran J Basic Med Sci 2017; 20:150-154.
8. Nazari Z, Nabiuni M, Ghaffari S, Saeidi M, Shahriyari A, Jafar Golalipour M. Gestational diabetes induces pancreatic beta-cells apoptosis in adult rat offspring. Int J Morphol 2017; 35:16-20.
9. Ghasemzadeh F, Golalipour M, Haidari K, Nazari Z, Golalipour MJ. Gestational diabetes influences bone morphogenic protein signaling during heart development in C57BL mice. J Anat Soc India 2021; 70:197.
10. Brunert D, Rothermel M. Extrinsic neuromodulation in the rodent olfactory bulb. Cell Tissue Res 2021; 383:507-524.
11. Lietzau G, Davidsson W, Östenson C-G, Chiazza F, Nathanson D, Pintana H, et al. Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin. Acta Neuropathol Commun 2018; 6:1-15.
12. Poessel M, Breuer N, Joshi A, Pampel A, Villringer A, Hummel T, et al. Reduced olfactory bulb volume in obesity and its relation to metabolic health status. Front Hum Neurosci 2020; 14:586998.
13. Kim SJ, Windon MJ, Lin SY. The association between diabetes and olfactory impairment in adults: A systematic review and meta‐analysis. Laryngoscope Investig Otolaryngol 2019; 4:465-475.
14. Lende M, Rijhsinghani A. Gestational diabetes: Overview with emphasis on medical management. Int J Environ Res Public Health
2020; 17:1-12.
15. Beauquis J, Saravia F, Coulaud J, Roig P, Dardenne M, Homo-Delarche F, et al. Prominently decreased hippocampal neurogenesis in a spontaneous model of type 1 diabetes, the nonobese diabetic mouse. Exp Neurol 2008; 210:359-367.
16. Plagemann A, Harder T, Lindner R, Melchior K, Rake A, Rittel F, et al. Alterations of hypothalamic catecholamines in the newborn offspring of gestational diabetic mother rats. Brain Res Dev Brain Res1998; 109:201-209.
17. Nocera S, Simon A, Fiquet O, Chen Y, Gascuel J, Datiche F, et al. Somatostatin serves a modulatory role in the mouse olfactory bulb: Neuroanatomical and behavioral evidence. Front Behav Neurosci 2019; 13:1-20.
18. Capsoni S, Fogli Iseppe A, Casciano F, Pignatelli A. Unraveling the role of dopaminergic and calretinin interneurons in the olfactory bulb. Front Neural Circuits 2021; 15:1-19.
19. Kosaka T, Kosaka K. Neuronal organization of the main olfactory bulb revisited. Anat Sci Int 2016; 91:115-127.
20. Nazari Z, Bahrehbar K, Sepehri H, Golalipour MJ. Curcumin can improve ecstasy-induced hippocampal damage in rat. J Toxicol Environ Health Sci 2023:173-179.
21. Cave JW, Baker H. Dopamine systems in the forebrain. Adv Exp Med Biol 2009:15-35.
22. Gaillard I, Rouquier S, Giorgi D. Olfactory receptors. Cell Mol Life Sci 2004; 61:456-469.
23. Berry M, Juorio A, Li X-M, Boulton A. Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem Res 1996; 21:1075-1087.
24. Alizadeh R, Hassanzadeh G, Soleimani M, taghi Joghataei M, Siavashi V, Khorgami Z, et al. Gender and age related changes in number of dopaminergic neurons in adult human olfactory bulb. J Chem Neuroanat 2015; 69:1-6.
25. Furman BL. Streptozotocin‐induced diabetic models in mice and rats. Curr Protoc Pharmacol 2021; 1:e78.
26. Akbarzadeh A, Norouzian D, Mehrabi M, Jamshidi S, Farhangi A, Verdi AA, et al. Induction of diabetes by streptozotocin in rats. Indian J Clin Biochem 2007; 22:60-64.
27. Qinna NA, Badwan AA. Impact of streptozotocin on altering normal glucose homeostasis during insulin testing in diabetic rats compared to normoglycemic rats. Drug Des Devel Ther 2015; 9:2515.
28. Nazari Z, Bahrebar K, Golalipour MJ. Effect of MDMA exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum. Iran J Basic Med Sci 2022; 25:1091.
29. Bahrehbar K, Gholami S, Nazari Z, Malakhond MK. Embryonic stem cells-derived mesenchymal stem cells do not differentiate into ovarian cells but improve ovarian function in POF mice. Biochem Biophys Res Commun 2022; 635:92-98.
30. Eslami N, Bahrehbar K, Esfandiari F, Shekari F, Hassani S-N, Nazari A, et al. Regenerative potential of different extracellular vesicle subpopulations derived from clonal mesenchymal stem cells in a mouse model of chemotherapy-induced premature ovarian failure. Life Sci 2023; 321:121536.
31. Bahrehbar K, Malakhond MK, Gholami S. Tracking of human embryonic stem cell-derived mesenchymal stem cells in premature ovarian failure model mice. Biochem Biophys Res Commun 2021; 577:6-11.
32. Faour M, Magnan C, Gurden H, Martin C. Olfaction in the context of obesity and diabetes: insights from animal models to humans. Neuropharmacology 2022; 206:108923.
33. Chan JYK, García-Esquinas E, Ko OH, Tong MC, Lin SY. The association between diabetes and olfactory function in adults. Chem Senses 2018; 43:59-64.
34. Pang NY-L, Song HJJMD, Tan BKJ, Tan JX, Chen ASR, See A, et al. Association of olfactory impairment with all-cause mortality: a systematic review and meta-analysis. JAMA Otolaryngol Head Neck Surg 2022; 148:436-445.
35. Gouveri E, Papanas N. Olfactory Dysfunction: A complication of diabetes or a factor that complicates glucose metabolism? A narrative review. J Clin Med 2021; 10:5637.
36. Huart C, Rombaux P, Hummel T. Plasticity of the human olfactory system: The olfactory bulb. Molecules 2013; 18:11586-11600.
37. Kosaka T, Kosaka K. “Interneurons” in the olfactory bulb revisited. Neurosci Res 2011; 69:93-99.
38. Huisman E, Uylings HB, Hoogland PV. A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson’s disease. J Mov Disord 2004; 19:687-692.
39. Mozzanica F, Ferrulli A, Vujosevic S, Montuori A, Cardella A, Preti A, et al. Olfactory disfunction and diabetic complications in type 2 diabetic patients: A pilot study. Endocrine 2022:75:760-767.
40. Dennis J, Coleman E, Swyers S, Moody S, Wright J, Judd R, et al. Changes in mitotic rate and GFAP expression in the primary olfactory axis of streptozotocin-induced diabetic rats. J Neurocytol 2005; 34:3-10.
41.Vafaei-Nezhad S, Vafaei-Nezhad M, Shadi M, Ezi S. The Impact of Diabetes on Hippocampus. Hippocampus-Cytoarchitecture and Diseases: IntechOpen; 2021.
42. Vuong B, Odero G, Rozbacher S, Stevenson M, Kereliuk SM, Pereira TJ, et al. Exposure to gestational diabetes mellitus induces neuroinflammation, derangement of hippocampal neurons, and cognitive changes in rat offspring. J Neuroinflammation 2017; 14:1-13.
43. Gellrich J, Dabow M-L, Vogelberg C, Reschke F, Näke A, von der Hagen M, et al. Influence of chronic diseases on the olfactory function in children. Eur J Pediatr 2019; 178:1185-1193.
44. Weihe E, Depboylu C, Schütz B, Schäfer MK-H, Eiden LE. Three types of tyrosine hydroxylase-positive CNS neurons distinguished by dopa decarboxylase and VMAT2 co-expression. Cell Mol Neurobiol 2006; 26:657-676.
45. Huisman E, Uylings HB, Hoogland PV. Gender‐related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson’s disease patients. J Mov Disord 2008; 23:1407-1413.
46. Parrish‐Aungst S, Shipley M, Erdelyi F, Szabo G, Puche A. Quantitative analysis of neuronal diversity in the mouse olfactory bulb. J Comp Neurol 2007; 501:825-836.

آمار
تعداد مشاهده مقاله: 497
تعداد دریافت فایل اصل مقاله: 419