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Hashemi Shiri, Zahra, Bagherpour, Tahereh, Nemati, Nematollah. (1402). The Simultaneous Effect of Curcumin Extract Supplementation and Aerobic Exercise on Leptin and Adiponectin Gene Expression in Visceral Adipose Tissue of Rats Receiving A High-Fat Diet. , 11(3), 215-224. doi: 10.22038/jnfh.2023.71546.1437
Zahra Hashemi Shiri; Tahereh Bagherpour; Nematollah Nemati. "The Simultaneous Effect of Curcumin Extract Supplementation and Aerobic Exercise on Leptin and Adiponectin Gene Expression in Visceral Adipose Tissue of Rats Receiving A High-Fat Diet". , 11, 3, 1402, 215-224. doi: 10.22038/jnfh.2023.71546.1437
Hashemi Shiri, Zahra, Bagherpour, Tahereh, Nemati, Nematollah. (1402). 'The Simultaneous Effect of Curcumin Extract Supplementation and Aerobic Exercise on Leptin and Adiponectin Gene Expression in Visceral Adipose Tissue of Rats Receiving A High-Fat Diet', , 11(3), pp. 215-224. doi: 10.22038/jnfh.2023.71546.1437
Hashemi Shiri, Zahra, Bagherpour, Tahereh, Nemati, Nematollah. The Simultaneous Effect of Curcumin Extract Supplementation and Aerobic Exercise on Leptin and Adiponectin Gene Expression in Visceral Adipose Tissue of Rats Receiving A High-Fat Diet. , 1402; 11(3): 215-224. doi: 10.22038/jnfh.2023.71546.1437

The Simultaneous Effect of Curcumin Extract Supplementation and Aerobic Exercise on Leptin and Adiponectin Gene Expression in Visceral Adipose Tissue of Rats Receiving A High-Fat Diet

Journal of Nutrition,Fasting and Health
مقاله 7، دوره 11، شماره 3، آذر 2023، صفحه 215-224    اصل مقاله (1.24 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22038/jnfh.2023.71546.1437
نویسندگان
Zahra Hashemi Shiri1؛ Tahereh Bagherpour* 2؛ Nematollah Nemati3
1PhD Student, Department of Sports Physiology, Islamic Azad University, Damghan Branch, Damghan, Iran.
2Assistance Professor, Department of Physical Education, Faculty of Humanities, Islamic Azad University, Damghan Branch, Damghan, Iran.
3Associate Professor, Department of Physical Education, Faculty of Humanities, Islamic Azad University, Damghan Branch, Damghan, Iran.
چکیده
Introduction: Herbal remedies can be helpful in the prevention and treatment of obesity, overweight, and related disorders. However, how aerobic exercise and curcumin supplementation interact with adipose tissue is still unclear. This study aimed to determine how aerobic exercise and supplementation with curcumin extract would affect leptin and adiponectin gene expression in visceral adipose tissue of rats fed a high-fat diet. Methods: In this study, 50 male rats were divided into five groups of equal size: control, high-fat diet, curcumin and high-fat diet, aerobic exercise and high-fat diet, and aerobic exercise and curcumin and high-fat diet. Five sessions per week of aerobic exercise were performed for six weeks at a speed of 25 to 29m/min for 20 to 45 minutes. Rats were given high-fat food emulsion of 0.5mg/kg of body weight per day for six weeks to simulate high-fat food groups. One-way analysis of variance (ANOVA) and Tukey’s post hoc test were employed in SPSS software version 22 to analyze the results. Results: There was no difference between the short-term effects of aerobic exercise, a high-fat diet, and curcumin extract on adiponectin gene expression in male rats (P=0.05). The short-term effects of aerobic exercise, a high-fat diet, and curcumin extract on the leptin gene expression in adipose tissue in male rats were comparable and not significantly different. Consuming curcumin, an antioxidant, and brief exercise affected the fat gene expression. Conclusions: Based on the results, both agent alone decreases or increases the expression of the adiponectin and leptin genes in fat, and when both agents are consumed simultaneously, the expression increases.
کلیدواژه‌ها
Aerobic exercise؛ Curcumin supplement؛ High-fat diet؛ Adiponectin؛ Leptin
مراجع
  1. Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017; 13(4):851-63.
  2. Gil-Cosano JJ, Gracia-Marco L, Courteix D, Lesourd B, Chapier R, Obert P, Walther G, Vinet A, Thivel D, Muñoz-Torres M, Ugbolue UC. Cardiorespiratory fitness and bone turnover markers in adults with metabolic syndrome: the mediator role of inflammation. Int J Sport Nutr Exerc Metab. 2022; 33(1):23-9.
  3. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev. Immunol. 2011; 11(2):85-97.
  4. Zouhal H, Bagheri R, Ashtary-Larky D, Wong A, Triki R, Hackney AC, Laher I, Abderrahman AB. Effects of Ramadan intermittent fasting on inflammatory and biochemical biomarkers in males with obesity. Physiol Behav. 2020 Oct 15; 225:113090.
  5. Popkin BM. The nutrition transition and obesity in the developing world. J Nutr; 2001; 131(3): 871S–3S.
  6. Troesch B, Biesalski HK, Bos R, Buskens E, Calder PC, Saris WH, Spieldenner J, Verkade HJ, Weber P, Eggersdorfer M. Increased intake of foods with high nutrient density can help to break the intergenerational cycle of malnutrition and obesity. Nutrients. 2015; 7(7):6016-37.
  7. Rolls BJ, Hammer VA. Fat, carbohydrate, and the regulation of energy intake. Am J Clin Nutr. 1995; 62(5 suppl):1086S–95S
  8. Frühbeck G, Catalán V, Rodríguez A, Ramírez B, Becerril S, Salvador J, Colina I, Gómez-Ambrosi J. Adiponectin-leptin ratio is a functional biomarker of adipose tissue inflammation. Nutrients. 2019; 11(2):454.
  9. Liu W, Zhou X, Li Y, Zhang S, Cai X, Zhang R, Gong S, Han X, Ji L. Serum leptin, resistin, and adiponectin levels in obese and non-obese patients with newly diagnosed type 2 diabetes mellitus: A population-based study. Medicine. 2020; 99(6). .
  10. Iikuni N, Kwan Lam QL, Lu L, Matarese G, Cava AL. Leptin and inflammation. Curr Immunol Rev. 2008; 4(2):70-9.
  11. Park E, Shin MJ, Chung N. The associations between serum leptin, adiponectin and intercellular adhesion molecule-1 in hypercholesterolemic patients. Nutr Res Pract. 2007; 1(1): 65-9.
  12. Laughlin GA, Barrett-Connor E, May S, Langenberg C. Association of adiponectin with coronary heart disease and mortality. Am J Epidemiol. 2007; 165(2): 164-74.
  13. Sun Y, Xun K, Wang C, Zhao H, Bi H, Chen X, Wang Y. Adiponectin, an unlocking adipocytokine. Cardiovasc Ther. 2009; 27(1): 59-75.
  14. Polak J, Kovacova Z, Holst C, Verdich C, Astrup A, Blaak E, et al. Total adiponectin and adiponectin multimeric complexes in relation to weight loss-induced improvements in insulin sensitivity in obese women: the NUGENOB study. Eur J Endocrinol. 2008; 158(4): 533-41.
  15. Simpson KA, Singh MA. Effects of exercise on adiponectin; a systematic review. Obesity. 2008; 16: 241-256.
  16. Jones LW, Eves ND, Peddle CJ, Courneya KS, Haykowsky M, Kumar V, Winton TW, and Reiman T. Effects of pre surgical exercise training on systemic inflammatory markers among patients with malignant lung lesions. Appl Physiol Nutr Metab. 2009. 34(2): 197–202.
  17. Olson TP, Dengel DR, Leon AS, Schmitz KH. Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women. Int J Obes. 2007; 31(6): 996-1003.
  18. Jin, T.R. Curcumin and dietary polyphenol research: Beyond drug discovery. Acta Pharmacol Sin. 2018; 39(5): 779–86.
  19. Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 2017; 57(13):2889-95.
  20. Gupta, S.C.; Patchva, S.; Aggarwal, B.B. Therapeutic roles of curcumin: Lessons learned from clinical trials. AAPS J. 2013; 15:195–218.
  21. Bradford, P.G. Curcumin and obesity. BioFactors. 2013; 39(1): 78–87.
  22. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Cell Biol. 2009; 41(1):40-59.
  23. Sohaei S, Amani R, Tarrahi MJ, Ghasemi-Tehrani H. The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial. Complementary Ther Med. 2019; 47:102201.
  24. Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendía LE, Majeed M, Sahebkar A. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed Pharmacother. 2016; 82:578-82.
  25. Shehzad A, Ha T, Subhan F, Lee YS. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr. 2011; 50: 151-61.
  26. Shimizu K, Funamoto M, Sunagawa Y, Shimizu S, Katanasaka Y, Miyazaki Y, Wada H, Hasegawa K, Morimoto T. Anti-inflammatory action of curcumin and its use in the treatment of lifestyle-related diseases. Eur Cardiol Rev. 2019;14(2):117.
  27. Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L, Bertuccioli A. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. Eur Rev Med Pharmacol Sci. 2015; 19(21):4195–202.
  28. Akbari M, Lankarani KB, Tabrizi R, Ghayour-Mobarhan M, Peymani P, Ferns G, Ghaderi A, Asemi Z. The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. 2019; 10:649.
  29. Varì R, Scazzocchio B, Silenzi A, Giovannini C, Masella R. Obesity-associated inflammation: does curcumin exert a beneficial role?. Nutrients. 2021; 13(3):1021.
  30. Reddy JK, Rao MS. Lipid Metabolism & Liver Inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol. 2006; 290(5): G852-8.
  31. Sirico F, Bianco A, D'Alicandro G, Castaldo C, Montagnani S, Spera R, Di Meglio F, Nurzynska D. Effects of physical exercise on adiponectin, leptin, and inflammatory markers in childhood obesity: systematic review and meta-analysis. Child Obes. 2018;14(4):207-17.
  32. Saremi A. Comparison of the effects of endurance, resistance and concurrent training on insulin resistance and adiponectin-leptin ratio in diabetic rat. J Inflamm Dis. 2017; 21(3) :22-13
  33. Rostami Hashjin Z, Amirsasan R, Nikoukheslat S, Sari-Sarraf V. Effect of high intensity interval training with turmeric supplementation on visceral fat, subcutaneous abdominal fat and insulin resistance in obese females. Sport Physio. 2019; 11(43): 55-74.
  34. Lee CH, Kim AU, Pyun CW, Fukushima M, Han KH. Turmeric (curcuma longa) whole powder reduces accumulation of visceral fat mass and increases hepatic oxidative stress in rats fed a high-fat diet. Food Sci Biothechnol. 2014; 23(1):261-7.
  35. Proença AR, Sertié RA, Oliveira AC, Campaaa AB, Caminhotto RO, Chimin P, Lima FB. New concepts in white adipose tissue physiology. Braz. J Med Biol Res. 2014; 47:192-205.
  36. Knights AJ, Funnell AP, Pearson RC, Crossley M, Bell-Anderson KS. Adipokines and insulin action: A sensitive issue. Adipocyte. 2014; 3(2):88-96.
  37. Smitka K, Marešová D. Adipose tissue as an endocrine organ: an update on pro-inflammatory and anti-inflammatory microenvironment. Prague Medical report. 2015; 116(2):87-111.
38.Hemmatinafar M, Kordi M Choopani S, Choobineh S, Gharari Arefi R. The Effect of High Intensity Interval Training (HIIT) on Plasma Adiponectin Levels, Insulin Sensitivity and Resistance in Sedentary Young Men. ZUMS J. 2013; 21(84): 1-12.

  1. Kraemer RR, Castracane VD. Exercise and humoral Mediators of Peripheral Energy Balance: Ghrelin and Adiponectin. Exp Biol Med (Maywood); 2017; 232: 184-94.
  2. Dutheil F, Lesourd B, Courteix D, Chapier R, Doré E, Lac G. Blood lipids and adipokines concentrations during a 6-month nutritional and physical activity intervention for metabolic syndrome treatment. Lipids Health Dis. 2010; 31:148-55.
  3. Hu GX, Lin H, Lian QQ, Zhou SH, Guo J, Zhou HY, et al. Curcumin as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 1: Improving lipid profiles in high-fat-diet-treated rats. PLoS One. 2013; 8(3):e49976.
  4. Bradford PG. (). Curcumin and obesity. BioFactors. 2013; 39(1):78-87.
  5. Sohaei S, Amani R, Tarrahi MJ, Ghasemi-Tehrani H. The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial. Complementary Therapies in Medicine. 2019; 47:102201.
  6. Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, et al. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutrition Research. 2012; 32(10):795-9.
  7. Kocher A, Bohnert L, Schiborr C, Frank J. Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals. Molecular Nutrition & Food Research. 2016; 60(7):1555-63.
  8. Tabrizi R, Vakili S, Lankarani KB, Akbari M, Mirhosseini N, Ghayour-Mobarhan M, et al. The effects of curcumin on glycemic control and lipid profiles among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials. Current Pharmaceutical Design; 2018; 24(27):3184-99.
  9. Zingg JM, Hasan ST, Meydani M. Molecular mechanisms of hypolipidemic effects of curcumin. BioFactors. 2013; 39(1):101-21.
  10. Meydani M, Hasan ST. Dietary polyphenols and obesity. Nutrients. 2010; 2(7): 737-51.
  11. Nayak BS, Ramsingh D, Gooding S, Legall G, Bissram S, Mohammed A, et al. Plasma adiponectin levels are related to obesity, inflammation, blood lipids and insulin in type 2 diabetic and nondiabetic Trinidadians Primary Care Diabetes. 2020; 4(3):188-92.
  12. Akbarpour M. The Effect of Aerobic Training on Serum Adiponectin and Leptin Levels and Inflammatory Markers of Coronary Heart Disease in Obese Men. Middle East Journal of Scientific Research. 2013; 13(8):1-11.
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