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Sadeghi, Ramin, Taheri, Reza, Jangjoo, Ali, Pakdel, Akbar, Arjmand, Mohammad-Hassan, Motiei, Mohammad, Memar, Bahram, Aliakbarian, Mohsen. (1402). Evaluation of the diagnostic value of Sentinel Lymph Node in patients with gastric adenocarcinoma. , 12(1), 21-26. doi: 10.22038/aojnmb.2023.70461.1491
Ramin Sadeghi; Reza Taheri; Ali Jangjoo; Akbar Pakdel; Mohammad-Hassan Arjmand; Mohammad Reza Motiei; Bahram Memar; Mohsen Aliakbarian. "Evaluation of the diagnostic value of Sentinel Lymph Node in patients with gastric adenocarcinoma". , 12, 1, 1402, 21-26. doi: 10.22038/aojnmb.2023.70461.1491
Sadeghi, Ramin, Taheri, Reza, Jangjoo, Ali, Pakdel, Akbar, Arjmand, Mohammad-Hassan, Motiei, Mohammad, Memar, Bahram, Aliakbarian, Mohsen. (1402). 'Evaluation of the diagnostic value of Sentinel Lymph Node in patients with gastric adenocarcinoma', , 12(1), pp. 21-26. doi: 10.22038/aojnmb.2023.70461.1491
Sadeghi, Ramin, Taheri, Reza, Jangjoo, Ali, Pakdel, Akbar, Arjmand, Mohammad-Hassan, Motiei, Mohammad, Memar, Bahram, Aliakbarian, Mohsen. Evaluation of the diagnostic value of Sentinel Lymph Node in patients with gastric adenocarcinoma. , 1402; 12(1): 21-26. doi: 10.22038/aojnmb.2023.70461.1491

Evaluation of the diagnostic value of Sentinel Lymph Node in patients with gastric adenocarcinoma

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 3، دوره 12، شماره 1، فروردین 2024، صفحه 21-26    اصل مقاله (1 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2023.70461.1491
نویسندگان
Ramin Sadeghi1؛ Reza Taheri2، 3؛ Ali Jangjoo2؛ Akbar Pakdel2، 3؛ Mohammad-Hassan Arjmand4؛ Mohammad Reza Motiei2؛ Bahram Memar5؛ Mohsen Aliakbarian* 2، 4
1Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
4Transplant Research Center, Clinical research institute, Mashhad University of Medical Sciences, Mashhad, Iran
5Department of Pathology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s):  Sentinel lymph node biopsy (SLNB) has been proven as a safe and efficient procedure in some cancers like breast cancer and melanoma with a reduction of complications and side effects of unnecessary lymphadenectomy in many patients. However, the diagnostic value of SLNB in gastric cancer is a point of debate. This study evaluated the diagnostic value of SLNB using radiotracer and isosulphan blue dye injection in patients with Gastric Adenocarcinomas (GA).
Methods: This descriptive study was performed at Imam-Reza HOSPITAL on 39 patients diagnosed with GA with no lymphatic metastasis using two methods: the combination of radionuclide with isosulphan together (R&I) method compared with the isosulphan alone method. Lymphatic dissection was performed in all patients. The pathological results were compared between the sentinel lymph nodes (SLN) and other lymph nodes and their accordance rate was calculated.
Results: In the T1 group, the sentinel lymph node biopsy detection rate was 100% for the combination of the R&I method and 60% for the isosulphan method and the false negative rate was zero. These values respectively were 88.8% and 88.8% in the T2 group with a false negative rate of 75%. In the T3 group, the values were 100% for the combination of the R&I method and 93.7% for the isosulphan method with a false negative rate of 40%. In the combination of the R&I method, the sensitivity, specificity, and positive and negative predictive values were 57.9, 100, 100, and 69.2 percent respectively.
Conclusion: Based on the false negative rate (47.4%), SLNB by injection of isosulphan blue dye alone is not a diagnostic enough value for predicting lymph node metastasis in GA. Although, SLNB by combination of the R&I had better accuracy compared to the isosulphan alone, more studies with larger samples are needed to prove this result.
کلیدواژه‌ها
Sentinel Lymph Node Biopsy؛ Gastric Adenocarcinoma؛ Metastasis؛ Isosulphan Blue dye
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