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Tajdini, Ardavan, Karimi Yazdi, Ali Reza, Ravand, Hamideh, Sahebi, Leyla. (1402). The Use of Herbal Medicine in Sudden Sensorineural Hearing Loss in Diabetic Patients. , 35(4), 207-215. doi: 10.22038/ijorl.2023.69813.3368
Ardavan Tajdini; Ali Reza Karimi Yazdi; Hamideh Ravand; Leyla Sahebi. "The Use of Herbal Medicine in Sudden Sensorineural Hearing Loss in Diabetic Patients". , 35, 4, 1402, 207-215. doi: 10.22038/ijorl.2023.69813.3368
Tajdini, Ardavan, Karimi Yazdi, Ali Reza, Ravand, Hamideh, Sahebi, Leyla. (1402). 'The Use of Herbal Medicine in Sudden Sensorineural Hearing Loss in Diabetic Patients', , 35(4), pp. 207-215. doi: 10.22038/ijorl.2023.69813.3368
Tajdini, Ardavan, Karimi Yazdi, Ali Reza, Ravand, Hamideh, Sahebi, Leyla. The Use of Herbal Medicine in Sudden Sensorineural Hearing Loss in Diabetic Patients. , 1402; 35(4): 207-215. doi: 10.22038/ijorl.2023.69813.3368

The Use of Herbal Medicine in Sudden Sensorineural Hearing Loss in Diabetic Patients

Iranian Journal of Otorhinolaryngology
دوره 35، شماره 4، مهر و آبان 2023، صفحه 207-215    اصل مقاله (830.17 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2023.69813.3368
نویسندگان
Ardavan Tajdini1؛ Ali Reza Karimi Yazdi2؛ Hamideh Ravand1؛ Leyla Sahebi* 3
1Otorhinolaryngology Research Center, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
2Otorhinolaryngology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
3Maternal, Fetal and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
چکیده
Introduction:
This study was conducted to evaluate the effect of Doluperine® capsule (curcumin, piperine, and gingerol) on hearing recovery in diabetic patients with Sudden Sensorineural Hearing Loss (SSNHL).
Materials and Methods:
Fifty-one diabetic patients with SSNHL were randomized to receive two placebo capsules (group 1), a Doluperine® plus one placebo capsule (group 2), or two Doluperine® capsules (group 3). Moreover, all patients had an injection of dexamethasone in the middle ear.
Results:
The proportion of significant positive changes in PTA, SDS, and SRT was 45.4%, 45.4%, and 36.37% in group1, 84.6%, 84.6%, and 76.92% in group 2, and 70%, 50.0%, and 80.0% in group 3, respectively. Many patients in group 3 did not respond to treatment in the first month, while they recovered at the end of the second month. The chance of recovery reduced with increased time between the onset of symptoms and treatment (delayed visitation) in group 1; however, this finding was not seen in groups 2 and 3.
Conclusion:
Doluperine® is recommended as a complementary medicine along with steroid therapy for hearing loss improvement in diabetic patients; moreover, this herbal medicine seems to play an important role in recovery in patients with delayed visitation.
کلیدواژه‌ها
Curcumin؛ Piperine؛ Gingerol؛ Sudden Sensorineural Hearing Loss؛ Diabetes
مراجع
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