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Arwanda, Muhammad, Haryuna, Tengku Siti, Adriztina, Indri, Khalid, Khalisanni. (1402). Curcumin Prevents Ototoxicity Induced by Cisplatin as Evaluated with OAE. , 35(4), 189-197. doi: 10.22038/ijorl.2023.71786.3452
Muhammad Dana Arwanda; Tengku Siti Hajar Haryuna; Indri Adriztina; Khalisanni Khalid. "Curcumin Prevents Ototoxicity Induced by Cisplatin as Evaluated with OAE". , 35, 4, 1402, 189-197. doi: 10.22038/ijorl.2023.71786.3452
Arwanda, Muhammad, Haryuna, Tengku Siti, Adriztina, Indri, Khalid, Khalisanni. (1402). 'Curcumin Prevents Ototoxicity Induced by Cisplatin as Evaluated with OAE', , 35(4), pp. 189-197. doi: 10.22038/ijorl.2023.71786.3452
Arwanda, Muhammad, Haryuna, Tengku Siti, Adriztina, Indri, Khalid, Khalisanni. Curcumin Prevents Ototoxicity Induced by Cisplatin as Evaluated with OAE. , 1402; 35(4): 189-197. doi: 10.22038/ijorl.2023.71786.3452

Curcumin Prevents Ototoxicity Induced by Cisplatin as Evaluated with OAE

Iranian Journal of Otorhinolaryngology
دوره 35، شماره 4، مهر و آبان 2023، صفحه 189-197    اصل مقاله (865.8 K)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2023.71786.3452
نویسندگان
Muhammad Dana Arwanda1؛ Tengku Siti Hajar Haryuna* 1؛ Indri Adriztina1؛ Khalisanni Khalid2
1Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
2Malaysian Agricultural Research and Development Institute (MARDI), MARDI Headquarters, Persiaran MARDI-UPM, 43400 Serdang, Selangor, Malaysia.
چکیده
Introduction:
This study, assess the efficacy of curcumin therapy in preventing/improving cochlear damage in Rattus norvegicus ototoxic model as evaluated with OAE examination.
Materials and Methods:
This study utilized 27 rats which had been injected with single dose 8mg/KgBB of cisplatin, and then divided into 3 groups. The first group was not given curcumin. The second group received curcumin at a dose of 150 mg/KgBB. The third group received curcumin at a dose of 300 mg/KgBB. Curcumin was given from the time of single dose cisplatin injection (day 0) to day 7. OAE examination was performed on the day before the single dose of cisplatin (day 0), day 3, 4 and 7 after curcumin administration.
 Results:
There was a decline in the average value of SNR in all groups starting from high frequency. However, in the rat groups receiving curcumin there was a slow decrease in the SNR value, which also obtained statistically significant differences in the SNR values of all groups.
 Conclusion:
Administration of certain doses of curcumin may reduce the modest and statistically insignificant decrease in mean SNR values indicating a reduction in ototoxicity from cisplatin.
کلیدواژه‌ها
Cisplatin؛ Curcumin؛ Cochear؛ Ototoxicity؛ Rattus norvegicus
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