سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Güler, Mustafa, Akpinar, Erol, Tanyeli, Ayhan, Çomakli, Selim, Bayir, Yasin. (1402). Costunolide prevents renal ischemia-reperfusion injury in rats by reducing autophagy, apoptosis, inflammation, and DNA damage. , 26(10), 1168-1176. doi: 10.22038/ijbms.2023.71779.15596
Mustafa Can Güler; Erol Akpinar; Ayhan Tanyeli; Selim Çomakli; Yasin Bayir. "Costunolide prevents renal ischemia-reperfusion injury in rats by reducing autophagy, apoptosis, inflammation, and DNA damage". , 26, 10, 1402, 1168-1176. doi: 10.22038/ijbms.2023.71779.15596
Güler, Mustafa, Akpinar, Erol, Tanyeli, Ayhan, Çomakli, Selim, Bayir, Yasin. (1402). 'Costunolide prevents renal ischemia-reperfusion injury in rats by reducing autophagy, apoptosis, inflammation, and DNA damage', , 26(10), pp. 1168-1176. doi: 10.22038/ijbms.2023.71779.15596
Güler, Mustafa, Akpinar, Erol, Tanyeli, Ayhan, Çomakli, Selim, Bayir, Yasin. Costunolide prevents renal ischemia-reperfusion injury in rats by reducing autophagy, apoptosis, inflammation, and DNA damage. , 1402; 26(10): 1168-1176. doi: 10.22038/ijbms.2023.71779.15596

Costunolide prevents renal ischemia-reperfusion injury in rats by reducing autophagy, apoptosis, inflammation, and DNA damage

Iranian Journal of Basic Medical Sciences
مقاله 7، دوره 26، شماره 10، دی 2023، صفحه 1168-1176    اصل مقاله (930.79 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.71779.15596
نویسندگان
Mustafa Can Güler* 1؛ Erol Akpinar2؛ Ayhan Tanyeli1؛ Selim Çomakli3؛ Yasin Bayir4
1Department of Physiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
2Department of Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
3Department of Pathology, Faculty of Veterinary, Atatürk University, Erzurum, Turkey
4Department of Biochemistry, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey
چکیده
Objective(s): Renal ischemia-reperfusion (I/R) is a vital health condition leading to acute kidney injury. Costunolide (COST) is an actively used molecule clinically for its anti-inflammatory, antioxidant, and immunomodulatory properties. In the present study, we searched for the possible protective effects of COST against renal ischemia/reperfusion (I/R) injury in rats.
Materials and Methods: We established a renal I/R rat model. We divided forty rats into four groups: group I (sham), group II (I/R), group III (I/R+COST 5 mg/kg), and group IV (I/R+COST 10 mg/kg). We collected blood, kidney, and lung samples for analysis. 
Results: COST administration performed anti-oxidant and anti-inflammatory activity by reducing oxidant parameters and proinflammatory cytokine levels. COST alleviated DNA damage through declining 8-hydroxydeoxyguanosine (8-OHdG) levels. In addition, COST diminished tubular damage and inflammation by reducing kidney injury molecule-1 (KIM-1) production. COST administration also ameliorated apoptosis and autophagy by decreasing caspase-3 and microtubule-associated protein light chain 3B (MAPLC3, LC3B) expression.
Conclusion: COST demonstrated protective effects against renal I/R-induced injury.
کلیدواژه‌ها
Apoptosis؛ Autophagy؛ Costunolide؛ Rat؛ Renal ischemia-reperfusion
مراجع
1. Bouchard J, Acharya A, Cerda J, Maccariello ER, Madarasu RC, Tolwani AJ, et al. A prospective international multicenter study of AKI in the intensive care unit. Clin J Am Soc Nephrol 2015; 10:1324-1331.
2. Topdağı Ö, Tanyeli A, Akdemir FNE, Eraslan E, Güler MC, Çomaklı S. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life Sci 2020; 242:117217-117224.
3. Li Z, Zhu J, Wan Z, Li G, Chen L, Guo Y. Theaflavin ameliorates renal ischemia/reperfusion injury by activating the Nrf2 signalling pathway in vivo and in vitro. Biomed Pharmacother 2021; 134:111097-111105.
4. Smith SF, Hosgood SA, Nicholson ML. Ischemia-reperfusion injury in renal transplantation: 3 key signaling pathways in tubular epithelial cells. Kidney Int 2019; 95:50-56.
5. Chung J, Hur M, Cho H, Bae J, Yoon HK, Lee HJ, et al. The effect of remote ischemic preconditioning on serum creatinine in patients undergoing partial nephrectomy: A randomized controlled trial. J Clin Med 2021;10:1636-1636.
6. Mathis MR, Naik BI, Freundlich RE, Shanks AM, Heung M, Kim M, et al. Preoperative risk and the association between hypotension and postoperative acute kidney injury. Anesthesiology 2020; 132:461-475.
7. da Silva Junior GB, Vasconcelos Junior AG, Rocha AMT, de Vasconcelos VR, de Barros Neto J, Fujishima JS, et al. Acute kidney injury complicating bee stings-a review. Rev Inst Med Trop São Paulo 2017; 59:25-31.
8. Cheeseman KH, Slater TF. An introduction to free radical biochemistry. Br Med Bull 1993; 49:481-493.
9. Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, et al. Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 2008; 133:235-249.
10. Klebanoff SJ. Myeloperoxidase: Friend and foe. J Leukoc Biol 2005; 77:598-625.
11. Wang B, Luo T, Chen D, Ansley DM. Propofol reduces apoptosis and up-regulates endothelial nitric oxide synthase protein expression in hydrogen peroxide-stimulated human umbilical vein endothelial cells. Anesth Analg 2007; 105:1027-1033.
12. Liu S, Yang Y, Gao H, Zhou N, Wang P, Zhang Y, et al. Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation. Am J Physiol Renal Physiol 2020; 318:F994-F1005.
13. Al-Taie A, Sancar M, Izzettin FV. 8-Hydroxydeoxyguanosine: A valuable predictor of oxidative DNA damage in cancer and diabetes mellitus. Cancer 2021;17:179-187.
14. Altintas R, Parlakpinar H, Beytur A, Vardi N, Polat A, Sagir M, et al. Protective effect of dexpanthenol on ischemia-reperfusion-induced renal injury in rats. Kidney Blood Press Res 2012; 36:220-230.
15. Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770-776.
16. Jang HR, Rabb H. Immune cells in experimental acute kidney injury. Nat Rev Nephrol 2014;11:88-101.
17. Leidal AM, Levine B, Debnath J. Autophagy and the cell biology of age-related disease. Nat Cell Biol 2018; 20:1338-1348.
18. Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol 2012; 298:229-317.
19. He Y, Zhao X, Subahan NR, Fan L, Gao J, Chen H. The prognostic value of autophagy-related markers beclin-1 and microtubule-associated protein light chain 3B in cancers: A systematic review and meta-analysis. Tumor Biol 2014; 35:7317-7326.
20. Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, et al. Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes. Nature Cell Biol 2019; 21:372-383.
21. de Souza-Pinto NC, Eide L, Hogue BA, Thybo T, Stevnsner T, Seeberg E, et al. Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. Cancer Res 2001; 61:5378-5381.
22. Wu D, Liu B, Yin J, Xu T, Zhao S, Xu Q, et al. Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2017; 1064:1-6.
23. Panah F, Ghorbanihaghjo A, Argani H, Haiaty S, Rashtchizadeh N, Hosseini L, et al. The effect of oral melatonin on renal ischemia–reperfusion injury in transplant patients: A double-blind, randomized controlled trial. Transpl Immunol 2019; 57:101241.
24. Ichimura T, Bonventre JV, Bailly V, Wei H, Hession CA, Cate RL, et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 1998; 273:4135-4142.
25. Agarwal A, Dong Z, Harris R, Murray P, Parikh SM, Rosner MH, et al. Cellular and molecular mechanisms of AKI. J Am Soc Nephrol 2016; 27:1288-1299.
26. Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV. Kidney injury molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury. Kidney Int 2002; 62:237-244.
27. Cai J, Jiao X, Luo W, Chen J, Xu X, Fang Y, et al. Kidney injury molecule-1 expression predicts structural damage and outcome in histological acute tubular injury. Ren Fail 2019; 41:80-87.
28. Song J, Yu J, Prayogo GW, Cao W, Wu Y, Jia Z, et al. Understanding kidney injury molecule 1: A novel immune factor in kidney pathophysiology. Am J Transl Res 2019; 11:1219-1229.
29. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. Am J Physiol Renal Physiol 2009; 297:125-137.
30. White LE, Cui Y, Shelak CMF, Lie ML, Hassoun HT. Lung endothelial cell apoptosis during ischemic acute kidney injury. Shock 2012; 38:320-327.
31. Ge Mx, Liu Ht, Zhang N, Niu Wx, Lu Zn, Bao Yy, et al. Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation. Br J Pharmacol 2020; 177:372-387.
32. Lv Q, Xing Y, Dong D, Hu Y, Chen Q, Zhai L, et al. Costunolide ameliorates colitis via specific inhibition of HIF1α/glycolysis-mediated Th17 differentiation. Int Immunopharmacol 2021; 97:107688-107688.
33. Kim DY, Choi BY. Costunolide-A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential. Int J Mol Sci 2019;20:2926-2946.
34. Xie F, Zhang H, Zheng C, Shen Xf. Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-κB, STAT1/3, and Akt signaling pathways. Int Immunopharmacol 2020; 84:106567-106567.
35. Fu Y, Tang C, Cai J, Chen G, Zhang D, Dong Z. Rodent models of AKI-CKD transition. Am J Physiol Renal Physiol 2018; 315:F1098-F1106.
36. Güler MC, Tanyeli A, Eraslan E, Çomakli S, Bayir Y. Cecal ligation and puncture-induced sepsis model in rats. J Lab Anim Sci Pract 2022; 2:81-89.
37. Nezamoleslami S, Sheibani M, Dehpour AR, Mobasheran P, Shafaroodi H. Glatiramer acetate attenuates renal ischemia reperfusion injury in rat model. Exp Mol Pathol 2020; 112:104329.
38. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem 1968; 25:192-205.
39. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351-358.
40. Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982; 78:206-209.
41. Peerapornratana S, Manrique-Caballero CL, Gómez H, Kellum JA. Acute kidney injury from sepsis: Current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int 2019; 96:1083-1099.
42. Hoste EAJ, Kellum JA, Selby NM, Zarbock A, Palevsky PM, Bagshaw SM, et al. Global epidemiology and outcomes of acute kidney injury. Nat Rev Nephrol 2018; 14:607-625.
43. Pan J, Zhang G, Hu Y, Jiang H, Tang X, Zhang D. MiR-6918-5p prevents renal tubular cell apoptosis by targeting MBD2 in ischemia/reperfusion-induced AKI. Life Sci 2022; 308:120921.
44. Wu MY, Yiang GT, Liao WT, Tsai APY, Cheng YL, Cheng PW, et al. Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem 2018; 46:1650-1667.
45. Jin J, Xu F, Zhang Y, Guan J, Liang X, Zhang Y, et al. Renal ischemia/reperfusion injury in rats is probably due to the activation of the 5-HT degradation system in proximal renal tubular epithelial cells. Life Sci 2021; 285:120002.
46. Zheng H, Chen Y, Zhang J, Wang L, Jin Z, Huang H, et al. Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation. Chem Biol Interact 2016; 250:68-77.
47. Liu B, Rong Y, Sun D, Li W, Chen H, Cao B, et al. Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β1/Smad2/Nrf2-NOX4 signaling pathways. Biochem Biophys Res Commun 2019; 510:329-333.
48. Butturini E, Di Paola R, Suzuki H, Paterniti I, Ahmad A, Mariotto S, et al. Costunolide and dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice. Eur J Pharmacol 2014; 730:107-115.
49. Eliza J, Daisy P, Ignacimuthu S. Anti-oxidant activity of costunolide and eremanthin isolated from Costus speciosus (Koen ex. Retz) Sm. Chem Biol Interact 2010; 188:467-472.
50. Wang Y, Zhang X, Zhao L, Shi M, Wei Z, Yang Z, et al. Costunolide protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by inhibiting NF-κB signaling pathway. J Surg Res 2017; 220:40-45.
51. Kang JS, Yoon YD, Lee KH, Park SK, Kim HM. Costunolide inhibits interleukin-1β expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells. Biochem Biophys Res Commun 2004; 313:171-177.
52. Lee BK, Park SJ, Nam SY, Kang S, Hwang J, Lee SJ, et al. Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments. J Ethnopharmacol 2018; 213:256-261.
53. Cheong CU, Yeh CS, Hsieh YW, Lee YR, Lin MY, Chen CY, et al. Protective effects of costunolide against hydrogen peroxide-induced injury in PC12 cells. Molecules 2016; 21:898-907.
54. Zhao Q, Cheng X, Wang X, Wang J, Zhu Y, Ma X. Neuroprotective effect and mechanism of Mu-Xiang-You-Fang on cerebral ischemia-reperfusion injury in rats. J Ethnopharmacol 2016; 192:140-147.
55. Jia Y, Chen X, Chen Y, Li H, Ma X, Xing W, et al. Zhenbao pill attenuates hydrogen peroxide–induced apoptosis by inhibiting autophagy in human umbilical vein endothelial cells. J Ethnopharmacol 2021; 274:114020.
56. Park C, Lee H, Noh JS, Jin CY, Kim GY, Hyun JW, et al. Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway. Arch Biochem Biophys 2020; 691:108512-108522.
57. Ng DSW, Liao W, Tan WSD, Chan TK, Loh XY, Wong WSF. Anti-malarial drug artesunate protects against cigarette smoke-induced lung injury in mice. Phytomedicine 2014; 21:1638-1644.
58. Magalhães EP, Silva BP, Aires NL, Ribeiro LR, Ali A, Cavalcanti MM, et al. (-)-α-Bisabolol as a protective agent against epithelial renal cytotoxicity induced by amphotericin B. Life Sci 2022; 291:120271.
59. Sampaio TL, Menezes RRPPBd, da Costa MFB, Meneses GC, Arrieta MCV, Chaves Filho AJM, et al. Nephroprotective effects of (-)-α-bisabolol against ischemic-reperfusion acute kidney injury. Phytomedicine 2016; 23:1843-1852.
60. Refaat B, El-Boshy M. Protective antioxidative and anti-inflammatory actions of β-caryophyllene against sulfasalazine-induced nephrotoxicity in rat. Exp Biol Med 2022; 247:691-699.

آمار
تعداد مشاهده مقاله: 733
تعداد دریافت فایل اصل مقاله: 567