سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Jafari-Sabet, Majid, Amiri, Shiva, Emami, Sahar, Aghamiri, Helia, Fatahi, Navid, Keyhanfar, Fariborz. (1402). Dorsal hippocampal CA1 NMDA receptors mediate the interactive effects of quetiapine and lithium on memory retention in male rats. , 26(9), 1090-1097. doi: 10.22038/ijbms.2023.69714.15177
Majid Jafari-Sabet; Shiva Amiri; Sahar Emami; Helia Aghamiri; Navid Fatahi; Fariborz Keyhanfar. "Dorsal hippocampal CA1 NMDA receptors mediate the interactive effects of quetiapine and lithium on memory retention in male rats". , 26, 9, 1402, 1090-1097. doi: 10.22038/ijbms.2023.69714.15177
Jafari-Sabet, Majid, Amiri, Shiva, Emami, Sahar, Aghamiri, Helia, Fatahi, Navid, Keyhanfar, Fariborz. (1402). 'Dorsal hippocampal CA1 NMDA receptors mediate the interactive effects of quetiapine and lithium on memory retention in male rats', , 26(9), pp. 1090-1097. doi: 10.22038/ijbms.2023.69714.15177
Jafari-Sabet, Majid, Amiri, Shiva, Emami, Sahar, Aghamiri, Helia, Fatahi, Navid, Keyhanfar, Fariborz. Dorsal hippocampal CA1 NMDA receptors mediate the interactive effects of quetiapine and lithium on memory retention in male rats. , 1402; 26(9): 1090-1097. doi: 10.22038/ijbms.2023.69714.15177

Dorsal hippocampal CA1 NMDA receptors mediate the interactive effects of quetiapine and lithium on memory retention in male rats

Iranian Journal of Basic Medical Sciences
مقاله 14، دوره 26، شماره 9، آذر 2023، صفحه 1090-1097    اصل مقاله (435.13 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.69714.15177
نویسندگان
Majid Jafari-Sabet* 1، 2؛ Shiva Amiri3، 4؛ Sahar Emami1؛ Helia Aghamiri1؛ Navid Fatahi1؛ Fariborz Keyhanfar1
1Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
4Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
چکیده
Objective(s): Lithium and quetiapine are administered simultaneously as a treatment for bipolar disorder. The concurrent use of these two drugs has been observed to affect the neurobiological mechanisms underlying learning and memory. To clarify the precise mechanisms involved, we evaluated the possible role of the dorsal hippocampal CA1 NMDA receptors in the interactive effects of lithium and quetiapine in memory consolidation. 
Materials and Methods: The dorsal hippocampal CA1 regions of adult male Wistar rats were bilaterally cannulated, and a single-trial step-through inhibitory avoidance apparatus was used to assess memory consolidation. 
Results: Post-training administration of certain doses of lithium (20, 30, and 40 mg/kg, IP) diminished memory consolidation. Post-training administration of higher doses of quetiapine (5, 10, and 20 mg/kg, IP) augmented memory consolidation. Post-training administration of certain doses of quetiapine (2.5, 5, 10, and 20 mg/kg) dose-dependently restored lithium-induced memory impairment. Post-training microinjection of ineffective doses of the NMDA (10-5 and 10-4 µg/rat, intra-CA1) plus an ineffective dose of quetiapine (2.5 mg/kg) restored the lithium-induced memory impairment. Post-training microinjection of ineffective doses of the noncompetitive NMDA receptor antagonist, MK-801 (0.0625 and 0.0125 μg/rat, intra-CA1), diminished the quetiapine-induced (10 mg/kg) memory improvement in lithium-induced memory impairment.
Conclusion: These findings suggest a functional interaction between lithium and quetiapine through hippocampal CA1 NMDA receptor mechanisms in memory consolidation.
کلیدواژه‌ها
Dorsal hippocampus؛ Lithium؛ MK-801؛ N-methyl-D-aspartic acid؛ Quetiapine
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