Metabolic syndrome is negatively associated with trabecular bone score and bone mineral density in normal weight adults with central obesity | ||
| Reviews in Clinical Medicine | ||
| دوره 10، شماره 2، شهریور 2023، صفحه 8-16 اصل مقاله (581.32 K) | ||
| نوع مقاله: Original article | ||
| شناسه دیجیتال (DOI): 10.22038/rcm.2023.72610.1455 | ||
| نویسندگان | ||
| Susan Darroudi1؛ Payam Sharifan2؛ Mahsa Rastegar Moghaddam Poorbagher3؛ Maryam Mohamadi Bajgiran1؛ Sara Saffar Soflaei4؛ Hamideh Ghazizadeh1؛ habibollah esmaily5؛ Niloofar Shabani6؛ Ramin Sadeghi7؛ Vahid Reza Dabbagh Kakhki7؛ Ali Ebrahimi Dabbagh8؛ Mohammad Amin Mohammadi8؛ Mohammad Amin Mohammadi8؛ sara Moazedi8؛ Mahdi Rafiee9؛ reza Assaran Darban10؛ Gordon A. Ferns11؛ Mohsen Mohebati12؛ majid Ghayour* 1 | ||
| 1International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran | ||
| 4International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 5Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 6Department of Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran | ||
| 7Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 8Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran | ||
| 9Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. | ||
| 10Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran 5. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 11Department of Medical Education, Brighton and Sussex Medical School, Falmer, Brighton, UK. | ||
| 12Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Introduction: Metabolic syndrome (MetS) is comprised of a clustering of various cardiovascular risk factors that can also affect bone health. We aimed the associations between MetS and bone mineral density (BMD) and trabecular bone score (TBS) in subjects with abdominal adiposity. Methods: Individuals with body mass index less than 25 kg/m2 were enrolled from the SUVINA study and allocated into two groups according criteria of IDF for metabolic syndrome. TBS T-score and Z/T score of fore skeletal region were measured using dual-energy X-ray absorptiometry (DXA). SPSS software was used for statistical analysis and p value 0<0.05 was considered significant. Results: DXA measurements were made in 201 participants, of whom 75 had MetS and 126 did not. Scores related to the neck of femur and total femur, radius Z-score and TBST-score were lower in subjects with MetS (all P<0.05). Subjects with FBG≥100 had lower TBST-score (p < 0.05). SBP≥130 and DBP≥85 in subjects, led to the lower TBST-score, and lumbar T-score (both P < 0.05). Subjects with (LDL-C≥160 mg/dl) had lower TBST-score, neck of femur Z score, and total femur T/Z scores (all P < 0.05). TBST-score and scores related to neck of femur, and total femur were lower in participants with serum cholesterol≥200 mg/dl (P < 0.05). Conclusion: MetS is negatively associated with TBS and BMD scores. Higher levels of LDL-C and cholesterol were the most associated factors related to TBST-score decrease. The neck of femur was the most vulnerable skeletal against the MetS components increment. | ||
| کلیدواژهها | ||
| Trabecular bone score؛ Bone mineral density؛ Metabolic syndrome؛ Serum lipids | ||
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