سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Hadipour, Elham, Rezazadeh Kafash, Mona, Emami, Seyed Ahmad, Asili, Javad, Boghrati, Zahra, Tayarani-Najaran, Zahra. (1402). Evaluation of anti-oxidant and antimelanogenic effects of the essential oil and extracts of Rosa × damascena in B16F10 murine melanoma cell line. , 26(9), 1076-1082. doi: 10.22038/ijbms.2023.69734.15182
Elham Hadipour; Mona Rezazadeh Kafash; Seyed Ahmad Emami; Javad Asili; Zahra Boghrati; Zahra Tayarani-Najaran. "Evaluation of anti-oxidant and antimelanogenic effects of the essential oil and extracts of Rosa × damascena in B16F10 murine melanoma cell line". , 26, 9, 1402, 1076-1082. doi: 10.22038/ijbms.2023.69734.15182
Hadipour, Elham, Rezazadeh Kafash, Mona, Emami, Seyed Ahmad, Asili, Javad, Boghrati, Zahra, Tayarani-Najaran, Zahra. (1402). 'Evaluation of anti-oxidant and antimelanogenic effects of the essential oil and extracts of Rosa × damascena in B16F10 murine melanoma cell line', , 26(9), pp. 1076-1082. doi: 10.22038/ijbms.2023.69734.15182
Hadipour, Elham, Rezazadeh Kafash, Mona, Emami, Seyed Ahmad, Asili, Javad, Boghrati, Zahra, Tayarani-Najaran, Zahra. Evaluation of anti-oxidant and antimelanogenic effects of the essential oil and extracts of Rosa × damascena in B16F10 murine melanoma cell line. , 1402; 26(9): 1076-1082. doi: 10.22038/ijbms.2023.69734.15182

Evaluation of anti-oxidant and antimelanogenic effects of the essential oil and extracts of Rosa × damascena in B16F10 murine melanoma cell line

Iranian Journal of Basic Medical Sciences
مقاله 12، دوره 26، شماره 9، آذر 2023، صفحه 1076-1082    اصل مقاله (351.13 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.69734.15182
نویسندگان
Elham Hadipour1؛ Mona Rezazadeh Kafash2؛ Seyed Ahmad Emami3؛ Javad Asili4؛ Zahra Boghrati3؛ Zahra Tayarani-Najaran* 2
1Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran
2Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): Rosa × damascena Herrm. belonging to the Rosaceae family has demonstrated anti-inflammatory and anti-oxidant effects previously. Excessive production of free radicals and activation of tyrosinase enzyme caused by UV induces excessive concentration of melanin pigment and skin spots in the long term. Therefore, finding natural sources with anti-oxidant and antityrosinase effects helps to regulate the melanogenesis process.  In the current research, we investigated the antimelanogenic, anti-oxidant, and anti-tyrosinase effects of its essential oil, methanol extract (MeOH), and different fractions including n-hexane, dichloromethane (CH2Cl2), n-butanol (BuOH), ethyl acetate (EtOAc), and H2O of R. × damascena in B16F10 cell line.
Materials and Methods: For this purpose, impacts of extracts and essential oil of R. × damascena were investigated on cell viability, cellular tyrosinase, melanin content, mushroom tyrosinase, reactive oxygen species (ROS) production, as well as the amount of tyrosinase protein in the B16F10 murine melanoma cell line.
Results: Essential oil, MeOH, and different fractions of R. × damascena were not cytotoxic on B16F10 cells. However, they had significant reducing effects on mushroom tyrosinase activity, melanin content, and ROS production. Also, there is a significant decrease in tyrosinase protein levels at 200 µg/ml but not at other concentrations. 
Conclusion: Therefore, the essential oil, MeOH, and different fractions of R. × damascena had promising antimelanogenic activity via repression of mushroom tyrosinase activity and ROS production.
کلیدواژه‌ها
B16F10 cell line؛ Melanogenesis؛ Rosa × damascene؛ ROS؛ Tyrosinase
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