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Bailey, Dale, Willowson, Kathy, Muñoz-Ferrada, Carl. (1402). A practical method for assessing quantitative scanner accuracy with long-lived radionuclides: The ARTnet insert. , 12(1), 27-34. doi: 10.22038/aojnmb.2023.71860.1503
Dale L Bailey; Kathy P Willowson; Carl Muñoz-Ferrada. "A practical method for assessing quantitative scanner accuracy with long-lived radionuclides: The ARTnet insert". , 12, 1, 1402, 27-34. doi: 10.22038/aojnmb.2023.71860.1503
Bailey, Dale, Willowson, Kathy, Muñoz-Ferrada, Carl. (1402). 'A practical method for assessing quantitative scanner accuracy with long-lived radionuclides: The ARTnet insert', , 12(1), pp. 27-34. doi: 10.22038/aojnmb.2023.71860.1503
Bailey, Dale, Willowson, Kathy, Muñoz-Ferrada, Carl. A practical method for assessing quantitative scanner accuracy with long-lived radionuclides: The ARTnet insert. , 1402; 12(1): 27-34. doi: 10.22038/aojnmb.2023.71860.1503

A practical method for assessing quantitative scanner accuracy with long-lived radionuclides: The ARTnet insert

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 4، دوره 12، شماره 1، فروردین 2024، صفحه 27-34    اصل مقاله (1.2 M)
نوع مقاله: Technical note
شناسه دیجیتال (DOI): 10.22038/aojnmb.2023.71860.1503
نویسندگان
Dale L Bailey* 1، 2؛ Kathy P Willowson1، 3؛ Carl Muñoz-Ferrada4
1Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia
2Faculty of Medicine & Health, University of Sydney, Sydney, Australia
3Institute of Medical Physics, University of Sydney, Sydney, Australia
4Globalsonics Institute for Medical Research, Sydney, Australia
چکیده
Objective(s): To address the problem of using large volumes of long-lived radionuclides in test phantoms to check calibration accuracy of PET and SPECT systems we have developed a test object which (a) contains less radioactivity, (b) has a low total volume, and (c) is easier to store than currently used phantoms, while still making use of readily-available “standardised” test objects.
Methods: We have designed a hollow acrylic cylindrical insert compatible with the NEMA/IEC PET Body Image Quality (IQ) phantom used in NU 2 performance testing of PET systems. The insert measures 90 mm internal diameter and 70 mm internal height and so is sufficiently large to not be subject to partial volume effects in PET or SPECT imaging. The volume of the insert is approximately 500 mL. It has been designed as a replacement for the standard long cylindrical “lung insert” in the IQ phantom without needing to remove the fillable hollow spheres of the phantom. The insert been tested with 18F, 68Ga and 124I PET/CT and 99mTc, 131I and 177Lu SPECT/CT on scanners that had previously been calibrated for these radionuclides.
Results: The scanners were found to produce accurate image reconstructions in the insert with ±5% of the true value without any confounding uncertainty from partial volume effects when compared to NEMA NU 2-2018 Phantom measurement.
Conclusions: The “ARTnet Insert” is simple to use, inexpensive, compatible with current phantoms and is suitable for both PET and SPECT systems. It does not suffer from significant partial volume losses permitting its use even with the poor spatial resolution of high-energy imaging with 131I SPECT. Furthermore, it uses less radioactivity in a smaller volume than would be required to fill the entire phantom as is usually done. Long-term storage is practical while allowing radioactive decay of the insert contents.
کلیدواژه‌ها
Site validation؛ Clinical Trial؛ PET؛ SPECT
مراجع
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  2. Bailey DL, Hofman MS, Forwood NJ, O'Keefe GJ, Scott AM, van Wyngaardt WM,et al. Accuracy of dose calibrators for 68Ga PET imaging: unexpected findings in a multicenter clinical pretrial assessment. J Nucl Med. 2018 r; 59(4):636-638.
  3. Francis R, Bailey DL, Hofman MS, Scott A. The Australasian Radiopharmaceutical Trials Network (ARTnet) - Clinical Trials, Evidence and Opportunity. J Nucl Med. 2020; 62:755-756.
  4. Ryu H, Meikle SR, Willowson KP, Eslick EM, Bailey DL. Performance evaluation of quantitative SPECT/CT using NEMA NU 2 PET methodology. Phys Med Biol. 2019; 64:145017.
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  6. NU 2-2018 performance measurements of positron emission tomographs. USA: National Electrical Manufacturers' Association; 2018.
  7. Bailey DL, Hennessy TM, Willowson KP, Henry EC, Chan DLH, Roach PJ. In vivo quantification of 177Lu with planar whole-body and SPECT/CT gamma camera imaging. Eur J Nucl Med Mol Imag Physics. 2015; 2:20.
  8. Kalisvaart GM, van Velden FH, Hernández‐Girón I, Meijer KM, Ghesquiere‐Dierickx LM, Brink WM, et al. Design and evaluation of a modular multimodality imaging phantom to simulate heterogeneous uptake and enhancement patterns for radiomic quantification in hybrid imaging: A feasibility study. Med Phys. 2022; 49:3093-3106.
  9. Graves S, Merrick M, Tiwari A, Sunderland J. Evaluation of a scalable qSPECT calibration method for radiopharmaceutical dosimetry. J Nucl Med. 2021; 62:1433.
  10. Dickson J, Cremonesi M, Denis-Bacelar A, Hristova I, Koole M, Peters SMB, et al. The EARL Quantitative 177Lu-SPECT-CT accreditation Eur J Nucl Med Mol Imag. 2022; 49: S187 (Abstract).
آمار
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