سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

شوقی, ملیکا, جعفری, شیما, خزدیر, محمد رضا. (1402). اثرات درمانی احتمالی ترکیبات فیتوشیمیایی مشتق شده ازگیاهان دارویی برکرونا ویروس، یک مقاله مروری. , 66(2), 242-258. doi: 10.22038/mjms.2023.67838.4018
ملیکا شوقی; شیما جعفری; محمد رضا خزدیر. "اثرات درمانی احتمالی ترکیبات فیتوشیمیایی مشتق شده ازگیاهان دارویی برکرونا ویروس، یک مقاله مروری". , 66, 2, 1402, 242-258. doi: 10.22038/mjms.2023.67838.4018
شوقی, ملیکا, جعفری, شیما, خزدیر, محمد رضا. (1402). 'اثرات درمانی احتمالی ترکیبات فیتوشیمیایی مشتق شده ازگیاهان دارویی برکرونا ویروس، یک مقاله مروری', , 66(2), pp. 242-258. doi: 10.22038/mjms.2023.67838.4018
شوقی, ملیکا, جعفری, شیما, خزدیر, محمد رضا. اثرات درمانی احتمالی ترکیبات فیتوشیمیایی مشتق شده ازگیاهان دارویی برکرونا ویروس، یک مقاله مروری. , 1402; 66(2): 242-258. doi: 10.22038/mjms.2023.67838.4018

اثرات درمانی احتمالی ترکیبات فیتوشیمیایی مشتق شده ازگیاهان دارویی برکرونا ویروس، یک مقاله مروری

مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
مقاله 10، دوره 66، شماره 2، خرداد و تیر 1402، صفحه 242-258    اصل مقاله (1.11 M)
نوع مقاله: مقاله مروری
شناسه دیجیتال (DOI): 10.22038/mjms.2023.67838.4018
نویسندگان
ملیکا شوقی1؛ شیما جعفری2؛ محمد رضا خزدیر* 3
1کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی بیرجند ، بیرجند، ایران
2گروه داروسازی بالینی، دانشکده داروسازی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران
3مرکز تحقیقات بیماری های قلب و عروق ، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران
چکیده
بیماری کرونا ویروس 2019 یا سندرم حاد تنفسی کرونا ویروس 2 (SARS-CoV-2) یک بیماری ویروسی جدید می‌باشد که در پایان سال 2019 شناسایی شد. در چندین مطالعه‌ی اخیر، استفاده ازگیاهان و ترکیبات فیتوشیمیایی مشتق شده از آن‌ها به منظور تقویت سیستم ایمنی گزارش شده است. مطالعه‌ی کنونی به بررسی خواص درمانی احتمالی ترکیبات فیتوشیمیایی بر ویروس SARS-CoV-2 پرداخته است.
کلمات کلیدی؛ شامل کووید-19، سارس-کووید2، فیتوشیمیایی یا فلاونوئید یا ترکیب طبیعی در قسمت عنوان یا چکیده مقاله هستند که تا تاریخ فوریه 2021 در پایگاه‌های اطلاعاتی علمی، پایگاه علمی ISI، پاب مد، اسکوپوس و گوگل اسکالرجستجو شدند.
ترکیبات فیتوشیمیایی؛ شامل تیموکینون، کامفرول، هسپریدین و کوئرستین هستند که خواص ضد ویروسی از جمله مهار پروتئین کیناز B و فسفوریلاسیون پروتئین کیناز و همچنین اثرات مسدودکننده بر روی یک کانال انتخابی بیان شده در سلول آلوده به SARS-CoV-2 (کانال a3) را نشان دادند. مواد فیتوشیمیایی همچنین سطح سیتوکین‌های پیش التهابی از جمله TNF-α، IL-6، IL-6، IL-1α، IL-1β و کموکاین‌ها را کاهش دادند.
مواد فیتوشیمیایی به دلیل اثرات ضد ویروسی، ضد التهابی و تعدیل کننده سیستم ایمنی ممکن است، اثرات مفیدی در کنترل یا درمان بیماری های عفونی مانند SARS-CoV-2 داشته باشند.
کلیدواژه‌ها
ویروس کرونا؛ مواد فیتوشیمیایی؛ اثرات ضد التهابی؛ اثرات ضد ویروسی
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