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Mirshafiei, Marziehsadat, Yazdi, Azadeh, Beheshti, Siamak. (1402). Neuroprotective and anti-neuroinflammatory activity of frankincense in bile duct ligation-induced hepatic encephalopathy. , 26(8), 966-971. doi: 10.22038/ijbms.2023.68775.14991
Marziehsadat Mirshafiei; Azadeh Yazdi; Siamak Beheshti. "Neuroprotective and anti-neuroinflammatory activity of frankincense in bile duct ligation-induced hepatic encephalopathy". , 26, 8, 1402, 966-971. doi: 10.22038/ijbms.2023.68775.14991
Mirshafiei, Marziehsadat, Yazdi, Azadeh, Beheshti, Siamak. (1402). 'Neuroprotective and anti-neuroinflammatory activity of frankincense in bile duct ligation-induced hepatic encephalopathy', , 26(8), pp. 966-971. doi: 10.22038/ijbms.2023.68775.14991
Mirshafiei, Marziehsadat, Yazdi, Azadeh, Beheshti, Siamak. Neuroprotective and anti-neuroinflammatory activity of frankincense in bile duct ligation-induced hepatic encephalopathy. , 1402; 26(8): 966-971. doi: 10.22038/ijbms.2023.68775.14991

Neuroprotective and anti-neuroinflammatory activity of frankincense in bile duct ligation-induced hepatic encephalopathy

Iranian Journal of Basic Medical Sciences
مقاله 15، دوره 26، شماره 8، آبان 2023، صفحه 966-971    اصل مقاله (857.49 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.68775.14991
نویسندگان
Marziehsadat Mirshafiei1؛ Azadeh Yazdi2؛ Siamak Beheshti* 1
1Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
2Department of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, Iran
چکیده
Objective(s): Hepatic encephalopathy induces cognitive disturbances. Patients show neuroinflammation due to accumulation of toxic substances. Frankincense has neuroprotective and anti-inflammatory properties. Accordingly, we intended to evaluate the impact of frankincense on memory performance, inflammation, and the amount of hippocampal neurons in bile duct-ligated rats.
Materials and Methods: The bile duct was ligated in three groups of adult male Wistar rats (BDL groups). In two of these groups, frankincense was administered (100 or 200 mg/kg; by gavage) starting from one week before surgery to 28 days after surgery. The third BDL group received saline. In the sham group, the bile duct was not ligated and the animals received saline. Twenty-eight days after surgery, spatial memory was evaluated by the Morris water maze test. Five rats from each group were sacrificed to measure the expression of the hippocampal tumor necrosis factor-alpha (TNF-α). Three rats from each group were perfused to determine the amount of hippocampal neurons. 
Results: Bile duct ligation impaired memory acquisition, while frankincense amended it. Bile duct ligation significantly increased the expression of TNF-α. Frankincense reduced TNF-α in BDL rats, significantly. The number of neurons in the hippocampal CA1 and CA3 areas was significantly lower in the BDL group and in the group that received frankincense (100 mg/kg) equated to the sham group. Frankincense (200 mg/kg) augmented the amount of neurons in the CA1 area, slightly and in the CA3 area, significantly. 
Conclusion: The results indicate the anti-inflammatory and neuroprotective effects of frankincense in bile duct ligation-induced hepatic encephalopathy.
کلیدواژه‌ها
Frankincense؛ Hepatic encephalopathy؛ Hippocampus؛ Neuroprotection؛ Tumor necrosis factor alpha
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