Aebi H. 1983. Catalase. In: Bergmeyer, H.U.
(Ed.), Methods in Enzymatic Analysis.
Academic Press, New York, pp. 276-286.
Afsar T, Razak S, Almajwal A, Al-Disi D.
2020. Doxorubicin-induced alterations in
kidney functioning, oxidative stress, DNA
damage, and renal tissue morphology;
Improvement by Acacia hydaspica
tannin-rich ethyl acetate fraction. Saudi J
Biol Sci, 27: 2251-2260.
Ahn J, Woo T-G, Kang S, Jo I, Woo J-S, Park
B-J, Ha N-C. 2021. The flavonoid morin
alleviates nuclear deformation in aged
cells by disrupting progerin-lamin A/C
binding. J Funct Foods, 77: 104331.
Ashrafizadeh M, Zarrabi A, Hashemi F,
Moghadam ER, Hashemi F, Entezari M,
Hushmandi K, Mohammadinejad R,
Najafi M. 2020. Curcumin in cancer
therapy: A novel adjunct for combination
chemotherapy with paclitaxel and
alleviation of its adverse effects. Life Sci,
256: 117984.
Athira KV, Madhana RM, Kasala ER,
Samudrala PK, Lahkar M, Gogoi R. 2016.
Morin hydrate mitigates cisplatin-induced
renal and hepatic injury by impeding
oxidative/nitrosative stress and
inflammation in mice. J Biochem Mol
Toxicol, 30: 571-579.
Benzer F, Kandemir FM, Kucukler S, Comaklı
S, Caglayan C. 2018. Chemoprotective
effects of curcumin on doxorubicininduced nephrotoxicity in wistar rats: by
modulating inflammatory cytokines,
apoptosis, oxidative stress and oxidative
DNA damage. Arch Physiol Biochem,
124: 448-457.
Beutler E. 1975. Glutathione in red blood cell
metabolism. A Manual of Biochemical
Methods. Grunee and Stratton, New
York, pp. 112-114.
Çelik H, Kucukler S, Çomaklı S, Özdemir S,
Caglayan C, Yardım A, Kandemir FM.
2020. Morin attenuates ifosfamideinduced neurotoxicity in rats via
suppression of oxidative stress,
neuroinflammation and neuronal
apoptosis. Neurotoxicology, 76: 126-137.
Chatterjee K, Zhang J, Honbo N, Karliner JS.
2010. Doxorubicin cardiomyopathy.
Cardiol, 115: 155-162.
Donmez DB, Kacar S, Bagci R, Sahinturk V.
Morin resists DOX hepatorenal toxicity
AJP, Vol. 13, No. 5, Sep-Oct 2023 485
2020. Protective effect of carnosic acid on
acrylamide‐induced liver toxicity in rats:
Mechanistic approach over Nrf2‐Keap1
pathway. J Biochem Mol Toxicol, 34:
e22524.
Egba SI, Famurewa AC, Omoruyi1 LE. 2020.
Buchholzia coriacea seed extract
attenuates mercury-induced cerebral and
cerebellar oxidative neurotoxicity via NO
signaling and suppression of oxidative
stress, adenosine deaminase and
acetylcholinesterase activities in rats.
Avicenna J Phytomed, 12: 42-53.
El-Far AH, Oyinloye BE, Sepehrimanesh M,
Allah MA, Abu-Reidah I, Shaheen HM,
Razeghian-Jahromi I, Alsenosy AA,
Noreldin AE, Al Jaouni SK, Mousa SA.
2019. Date Palm (Phoenix dactylifera):
novel findings and future directions for
food and drug discovery. Curr Drug
Discov Technol, 16: 2-10.
El-Far AH, Godugu K, Noreldin AE, Saddiq
AA, Almaghrabi OA, Al Jaouni SK,
Mousa SA. 2021. Thymoquinone and
costunolide induce apoptosis of both
proliferative and doxorubicin-inducedsenescent colon and breast cancer cells.
Integr Cancer Ther, 20:
15347354211035450.
Famurewa AC, Maduagwuna EK, Folawiyo
AM, Besong EE, Eteudo AN, Famurewa
OA, Ejezie FE. 2020. Antioxidant, anti‐
inflammatory, and antiapoptotic effects of
virgin coconut oil against antibiotic drug
gentamicin‐induced nephrotoxicity via the
suppression of oxidative stress and
modulation of iNOS/NF‐ĸB/caspase‐3
signaling pathway in Wistar rats. J Food
Biochem, 44: e13100.
Famurewa AC, Asogwa NT, Aja PM, Akunna
GG, Awoke JN, Ekeleme-Egedigwe CA,
Maduagwuna EK, Folawiyo AM, Besong
EE, Ekpono EU, Nwoha PA. 2019.
Moringa oleifera seed oil modulates
redox imbalance and iNOS/NF-ĸB/
caspase-3 signaling pathway to exert
antioxidant, anti-inflammatory and
antiapoptotic mechanisms against
anticancer drug 5-fluorouracil-induced
nephrotoxicity in rats. South Afr J Bot,
127: 96-103.
Famurewa AC, Ejezie AJ, Ugwu-Ejezie CS,
Ikekpeazu EJ, Ejezie FE. 2018.
Antioxidant and anti-inflammatory
mechanisms of polyphenols isolated from
virgin coconut oil attenuate cadmiuminduced oxidative stress-mediated
nephrotoxicity and inflammation in rats. J
Appl Biomed, 16: 281-288.
Fang SH, Hou YC, Chang WC, Hsiu SL, Chao
PD, Chiang BL. 2003. Morin sulfates/
glucuronides exert anti-inflammatory
activity on activated macrophages and
decreased the incidence of septic shock.
Life Sci, 74: 743-756.
Green LC, Wagner DA, Glogowski J, Skipper
PL, Wishnok JS, Tannenbaum SR. 1982.
Analysis of nitrate, nitrite, and [15N]
nitrate in biological fluids. Ann Biochem,
126: 131-138.
Guo H, Liu Y, Wang L, Zhang G, Su S, Zhang
R, Zhang J, Li A, Shang C, Li Z. 2016.
Alleviation of doxorubicin–induced
hepatorenal toxicities with sesamin via
the suppression of oxidative stress.
Human Exp Toxicol, 35: 1183-1193.
Haidari F, Mohammadshahi M, Zarei M, Fathi
M. 2019. Protective effect of citrus lemon
on inflammation and adipokine levels in
acrylamide-induced oxidative stress in
rats. Braz J Pharm Sci, 55: e18285.
Hagag AA, Badraia IM, El-Shehaby WA,
Mabrouk MM. 2020. Protective role of
black seed oil in doxorubicin-induced
cardiac toxicity in children with acute
lymphoblastic leukemia. J Oncol Pharm
Pract, 26: 1397-1406.
Hassan MM, Gad AM, Menze ET, Osama A,
Badary OA, El-Naga RN. 2020.
Protective effects of morin against
depressive-like behavior prompted by
chronic unpredictable mild stress in rats:
Possible role of inflammasome-related
pathways. Biochem Pharmacol, 180:
114140.
Hekmat AS, Chenari A, Alipanah H,
Javanmardi K. 2021. Protective effect of
alamandine on doxorubicin‐induced
nephrotoxicity in rats. BMC Pharmacol
Toxicol, 22: 31-41.
Hussain MA, Abogresha NM, AbdelKader G,
Hassan R, Abdelaziz EZ, Greish SM.
2021. Antioxidant and anti-inflammatory
effects of crocin ameliorate doxorubicininduced nephrotoxicity in rats. Oxid Med
Cell Longev, 2021: 8841726.
Jiang B, Geng Q, Li T, Firdous SM, Zhou X.
2020. Morin attenuates STZ-induced
diabetic retinopathy in experimental
animals. Saudi J Biol Sci, 27: 2139-2142.
Famurewa et al.
AJP, Vol. 13, No. 5, Sep-Oct 2023 486
Khafaga AF, El-Kazaz SE, Noreldin AE.
2021. Boswellia serrata suppress fipronilinduced neuronal necrosis and
neurobehavioral alterations via promoted
inhibition of oxidative/
inflammatory/apoptotic pathways. Sci
Total Environ, 785: 147384.
Kok LD, Wong YP, Wu TW, Chan HC, Kwok
TT, Fung KP. 2000. Morin hydrate A
potential antioxidant in minimizing the
free-radicals-mediated damage to
cardiovascular cells by anti-tumor drugs.
Life Sci, 67: 91-99.
Kucukler S, Caglayan C, Darendelioğlu E,
Kandemir FM. 2020. Morin attenuates
acrylamide-induced testicular toxicity in
rats by regulating the NF-κB, Bax/Bcl-2
and PI3K/Akt/mTOR signaling pathways.
Life Sci, 261: 118301.
Kuzu M, Kandemir FM, Yildirim S, Kucukler
S, Caglayan C, Turk E. 2018. Morin
attenuates doxorubicin-induced heart and
brain damage by reducing oxidative
stress, inflammation and apoptosis.
Biomed Pharmacother, 106: 443-453.
Kuzu M, Yıldırım S, Kandemir FM, Küçükler
S, Çağlayan C, Türke E, Dörtbudak MB.
2019. Protective effect of morin on
doxorubicin-induced hepatorenal toxicity
in rats. Chem Biol Interact, 308: 89-100.
Liu X, Qiu Y, Liu Y, Huang N, Hua C, Wang
Q, Wu Z, Lu J, Song P, Xu J, Li P, Yin Y.
2021. Citronellal ameliorates
doxorubicin‐induced hepatotoxicity via
antioxidative stress, antiapoptosis, and
proangiogenesis in rats. J Biochem Mol
Toxicol, 35: e22639.
Marklund S, Marklund G. 1974. Involvement
of the superoxide anion radical in the auto
oxidation of pyrogallol and a convenient
assay for superoxide dismutase. Eur J
Biochem, 47: 469-474.
Moghaddam RH, Samimi Z, Moradi SZ, Little
PJ, Xu S, Farzaei MH. 2020. Naringenin
and naringin in cardiovascular disease
prevention: A preclinical review. Eur J
Pharmacol, 887: 173535.
Ohkawa H, Ohishi N, Yagi K. 1979. Assay for
lipid peroxides in animal tissues by
thiobarbituric acid reaction. Ann
Biochem, 95: 351-358.
Omidifar N, Nili-Ahmadabadi A, Gholami A,
Dastan D, Ahmadimoghaddam D, NiliAhmadabadi H. 2020. Biochemical and
histological evidence on the protective
effects of allium hirtifolium boiss (Persian
Shallot) as an herbal supplement in
cadmium-induced hepatotoxicity,” Evid
based Complement Alternat Med, 2020:
7457504.
Özdemir S, Kucukler S, Çomaklı S, Kandemir
FM. 2022. The protective effect of Morin
against ifosfamide-induced acute liver
injury in rats associated with the
inhibition of DNA damage and apoptosis.
Drug Chem Toxicol, 45: 1308-1317.
Paglia DE, Valentine WN. 1967. Studies on
the quantitative and qualitative
characterization of erythrocyte
glutathione peroxidase. J Lab Clin Med,
70: 158-169.
Prasanna PL, Renu K, Gopalakrishnan AV.
2020. New molecular and biochemical
insights of doxorubicin-induced
hepatotoxicity. Life Sci, 250: 117599.
Shivakumar P, Rani MU, Reddy AG,
Anjaneyulu Y. 2012. A study on the toxic
effects of doxorubicin on the histology of
certain organs. Toxicol Int, 19: 241-244.
Singh MP, Chauhan AK, Kang SC. 2018.
Morin hydrate ameliorates cisplatininduced ER stress, inflammation and
autophagy in HEK-293 cells and mice
kidney via PARP-1 regulation. Int
Immunopharmacol, 56: 156-167.
Sonowal H, Saxena A, Qiu S, Srivastava S,
Ramana KV. 2021. Aldose reductase
regulates doxorubicin-induced immune
and inflammatory responses by activating
mitochondrial biogenesis. Eur J
Pharmacol, 895: 173884.
Sultana F, Neog MK, Rasool M. 2017.
Targeted delivery of morin, a dietary
bioflavanol encapsulated mannosylated
liposomes to the macrophages of
adjuvant-induced arthritis rats inhibits
inflammatory immune response and
osteoclastogenesis. Eur J Pharm
Biopharm, 115: 229-242.
Thorn CF, Oshiro C, Marsh S, HernandezBoussard T, McLeod H, Klein TE,
Altman RB. 2011. Doxorubicin pathways:
pharmacodynamics and adverse effects.
Pharmacogenet Genomics, 21: 440-446.
Thurston DE. 2007. DNA-interacting agents.
Chemistry and Pharmacology of
anticancer drugs (p. 62). New York, NY:
CRC Press, Taylor and Francis Group.
Verma VK, Malik S, Mutneja E, Sahu AK,
Bhatia J, Arya DS. 2020. Attenuation of
Morin resists DOX hepatorenal toxicity
AJP, Vol. 13, No. 5, Sep-Oct 2023 487
ROS‐mediated myocardial ischemia–
reperfusion injury by morin via regulation
of RISK/SAPK pathways. Pharmacol
Reports, 72: 877-889.
Wang X, Chen Y, Zhu J, Yang Z, Gong X,
Hui R, Huang G, Jin J. 2021. A
comprehensive screening method for
investigating the potential binding targets
of doxorubicin based on protein
microarray. Eur J Pharmacol, 896:
173896.
Zhang Q-Y, Wang F-X, Jia K-K, Kong L-D.
2018. Natural product interventions for
chemotherapy and radiotherapy-induced
side effects. Front Pharmacol, 9: 1253.
Zhang Y, Li H, Zhang J, Zhao C, Lu S, Qiao J,
Han M. 2020. The combinatory effects of
natural products and chemotherapy drugs
and their mechanisms in breast cancer
treatment. Phytochem Rev, 19: 1179-
1197