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Yazadanpanah, Zahra, Ghasemzadeh Rahbardar, Mahboobeh, Razavi, Bibi Marjan, Hosseinzadeh, Hossein. (1402). Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods. , 26(9), 1024-1029. doi: 10.22038/ijbms.2023.69636.15167
Zahra Yazadanpanah; Mahboobeh Ghasemzadeh Rahbardar; Bibi Marjan Razavi; Hossein Hosseinzadeh. "Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods". , 26, 9, 1402, 1024-1029. doi: 10.22038/ijbms.2023.69636.15167
Yazadanpanah, Zahra, Ghasemzadeh Rahbardar, Mahboobeh, Razavi, Bibi Marjan, Hosseinzadeh, Hossein. (1402). 'Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods', , 26(9), pp. 1024-1029. doi: 10.22038/ijbms.2023.69636.15167
Yazadanpanah, Zahra, Ghasemzadeh Rahbardar, Mahboobeh, Razavi, Bibi Marjan, Hosseinzadeh, Hossein. Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods. , 1402; 26(9): 1024-1029. doi: 10.22038/ijbms.2023.69636.15167

Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods

Iranian Journal of Basic Medical Sciences
مقاله 5، دوره 26، شماره 9، آذر 2023، صفحه 1024-1029    اصل مقاله (924.85 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.69636.15167
نویسندگان
Zahra Yazadanpanah1؛ Mahboobeh Ghasemzadeh Rahbardar2؛ Bibi Marjan Razavi2، 3؛ Hossein Hosseinzadeh* 1، 2
1Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
3Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s):  Acrylamide (ACR) is an environmental contaminant and neurotoxin. Telmisartan is an AT1 blocker that has neuroprotective properties basically through its anti-oxidant effect. The effect of telmisartan on ACR-induced neurotoxicity was investigated in this study. 
Materials and Methods: Male Wistar rats were randomly assigned to eight groups (n=6): 1:Control (normal saline), 2:ACR (50 mg/kg, 11 days, IP), 3:ACR+vitamin E (200 mg/kg, every other day, 11 days), 4-6:ACR+telmisartan (0.6, 1.25, and 2.5 mg/kg, 11 days, IP), 7:ACR+telmisartan (0.6 mg/kg, days 3–11), 8:Telmisartan (2.5 mg/kg, 11 days). The behavioral test and blood pressure were assessed after 11 days. Then, the levels of MDA and GSH in brain tissue were measured. The MTT assay was used to evaluate the effect of telmisartan on ACR-induced cytotoxicity.
Results: Exposing PC12 cells to ACR decreased cell viability versus the control group. Pretreating PC12 cells with telmisartan (0.0125, 0.025 µM) enhanced cell viability compared with the ACR group. Compared with control samples, ACR significantly caused motor impairment, elevated MDA, and reduced GSH levels. Locomotor abnormalities were significantly ameliorated by telmisartan (0.6, 1.25 mg/kg, 11 days) and vitamin E versus the ACR group. Receiving telmisartan (0.6, 1.25, and 2.5 mg/kg) and vitamin E along with ACR decreased MDA levels and enhanced GSH content compared with the ACR group.  There was no significant difference in animal blood pressure between the groups.
Conclusion: Oxidative stress has a chief role in the neurotoxicity of ACR. Telmisartan (in doses that do not affect blood pressure) ameliorated ACR-induced toxicity by inhibiting oxidative stress.
کلیدواژه‌ها
Anti-oxidants؛ Cell survival؛ Motor disorders؛ Neurotoxins؛ PC12 cells؛ Vitamin E
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