سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Ahmadimanesh, Mahnaz, Etemad, Leila, Morshedi Rad, Dorsa, Ghahremani, Mohammad Hossein, Mohammadpour, Amir Hooshang, Jafarzadeh-Esfehani, Reza, Jowsey, Paul, Behdani, Fatemeh, Moallem, Adel, Abbaszadegan, Mohammad Reza. (1402). Effect of citalopram and sertraline on the expression of miRNA- 124, 132, and 16 and their protein targets in patients with depression. , 26(7), 820-829. doi: 10.22038/ijbms.2023.66496.14595
Mahnaz Ahmadimanesh; Leila Etemad; Dorsa Morshedi Rad; Mohammad Hossein Ghahremani; Amir Hooshang Mohammadpour; Reza Jafarzadeh-Esfehani; Paul Jowsey; Fatemeh Behdani; Adel Moallem; Mohammad Reza Abbaszadegan. "Effect of citalopram and sertraline on the expression of miRNA- 124, 132, and 16 and their protein targets in patients with depression". , 26, 7, 1402, 820-829. doi: 10.22038/ijbms.2023.66496.14595
Ahmadimanesh, Mahnaz, Etemad, Leila, Morshedi Rad, Dorsa, Ghahremani, Mohammad Hossein, Mohammadpour, Amir Hooshang, Jafarzadeh-Esfehani, Reza, Jowsey, Paul, Behdani, Fatemeh, Moallem, Adel, Abbaszadegan, Mohammad Reza. (1402). 'Effect of citalopram and sertraline on the expression of miRNA- 124, 132, and 16 and their protein targets in patients with depression', , 26(7), pp. 820-829. doi: 10.22038/ijbms.2023.66496.14595
Ahmadimanesh, Mahnaz, Etemad, Leila, Morshedi Rad, Dorsa, Ghahremani, Mohammad Hossein, Mohammadpour, Amir Hooshang, Jafarzadeh-Esfehani, Reza, Jowsey, Paul, Behdani, Fatemeh, Moallem, Adel, Abbaszadegan, Mohammad Reza. Effect of citalopram and sertraline on the expression of miRNA- 124, 132, and 16 and their protein targets in patients with depression. , 1402; 26(7): 820-829. doi: 10.22038/ijbms.2023.66496.14595

Effect of citalopram and sertraline on the expression of miRNA- 124, 132, and 16 and their protein targets in patients with depression

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 26، شماره 7، مهر 2023، صفحه 820-829    اصل مقاله (850.19 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.66496.14595
نویسندگان
Mahnaz Ahmadimanesh1، 2؛ Leila Etemad3، 4؛ Dorsa Morshedi Rad5؛ Mohammad Hossein Ghahremani6؛ Amir Hooshang Mohammadpour3، 7؛ Reza Jafarzadeh-Esfehani8، 9؛ Paul Jowsey10؛ Fatemeh Behdani11؛ Adel Moallem1، 12؛ Mohammad Reza Abbaszadegan* 8، 9
1Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2Food and Drug Vice Presidency, Mashhad University of Medical Sciences, Mashhad, Iran
3Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
4International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Center of Health Technologies, School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia
6Department of Toxicology-Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
7Department of clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
8Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
9Medical Genetics Research Center, Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran
10National Institute for Health Research (NIHR), Health Protection Research Unit for Chemical and Radiation Threats and Hazards, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK
11Psychiatry and Behavioral Sciences Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
12Department of Pharmacology and Toxicology, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq
چکیده
Objective(s): This study aimed to evaluate the effect of SSRIs on the expression of miRNAs and their protein targets.
Materials and Methods: In a 100 day open-label study of citalopram (n=25) and sertraline (n=25), levels of miRNA 16, 132, and 124 and glucocorticoid receptor (GR), Brain-derived neurotrophic factor (BDNF), and serotonin transporter (SERT) protein expression were measured by QRT-PCR and western blot in healthy control (n=20), patients with depression at the baseline, and same patients after 100 days of treatment.
Results: Expression levels of GR and BDNF proteins were lower in the depressed group before treatment as compared with the healthy group (P<0.0001). The SERT level was higher among the depressed group before treatment in comparison with the healthy group (P<0.0001). The level of GR and BDNF significantly increased, and SERT expression decreased after receiving sertraline (P<0.05). When the depressed group received citalopram, only SERT and GR were altered (P<0.05). Among the microRNAs’ expression investigated, mir-124 and mir-132 were higher, and mir-16 was lower among the depressed compared with the healthy group (P<0.0001). Individuals receiving citalopram only showed an increase in the expression of mir-16 while administration of sertraline led to a significant increase in the expression of mir-16 and a decrease in mir-124 and mir-132 (P<0.05).
Conclusion: This elucidated the relationship between antidepressant treatment and the expression of different microRNA that control gene expression in various pathways involved in depressed patients.  Receiving SSRI can affect the level of these proteins and their relevant microRNAs.
کلیدواژه‌ها
Citalopram؛ Depression؛ miRNAs؛ Sertraline؛ SSRIs
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