سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Mafinezhad, Shahin, Bayani, Gasem, Ehteshammanesh, Hojatollah, Langari, Mina, Shokrollahi, Nazi, Bozorgnia, Yasaman, Namdar Ahmadabad, Hasan. (1402). Evaluation of the side effects of Sinopharm and PastoCovac COVID-19 vaccines in children aged 5-12 years in Iran. , 11(4), 17572-17582. doi: 10.22038/ijp.2023.70478.5187
Shahin Mafinezhad; Gasem Bayani; Hojatollah Ehteshammanesh; Mina Langari; Nazi Shokrollahi; Yasaman Bozorgnia; Hasan Namdar Ahmadabad. "Evaluation of the side effects of Sinopharm and PastoCovac COVID-19 vaccines in children aged 5-12 years in Iran". , 11, 4, 1402, 17572-17582. doi: 10.22038/ijp.2023.70478.5187
Mafinezhad, Shahin, Bayani, Gasem, Ehteshammanesh, Hojatollah, Langari, Mina, Shokrollahi, Nazi, Bozorgnia, Yasaman, Namdar Ahmadabad, Hasan. (1402). 'Evaluation of the side effects of Sinopharm and PastoCovac COVID-19 vaccines in children aged 5-12 years in Iran', , 11(4), pp. 17572-17582. doi: 10.22038/ijp.2023.70478.5187
Mafinezhad, Shahin, Bayani, Gasem, Ehteshammanesh, Hojatollah, Langari, Mina, Shokrollahi, Nazi, Bozorgnia, Yasaman, Namdar Ahmadabad, Hasan. Evaluation of the side effects of Sinopharm and PastoCovac COVID-19 vaccines in children aged 5-12 years in Iran. , 1402; 11(4): 17572-17582. doi: 10.22038/ijp.2023.70478.5187

Evaluation of the side effects of Sinopharm and PastoCovac COVID-19 vaccines in children aged 5-12 years in Iran

International Journal of Pediatrics
مقاله 3، دوره 11، شماره 4، تیر 2023، صفحه 17572-17582    اصل مقاله (336.09 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2023.70478.5187
نویسندگان
Shahin Mafinezhad1؛ Gasem Bayani1؛ Hojatollah Ehteshammanesh1؛ Mina Langari2؛ Nazi Shokrollahi3؛ Yasaman Bozorgnia4؛ Hasan Namdar Ahmadabad* 5
1Assistant Professor of Neonatology, Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran
2Department of Pediatrics, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3Health center of Bojnurd, North Khorasan University of Medical Sciences, Bojnurd, Iran
4Department of Orthodontics, North Khorasan University of Medical Sciences, Bojnurd, Iran
5Vector-borne Diseases Research Center, North Khorasan University of Medical, Bojnurd, Iran
چکیده
Background: Vaccination of children against COVID-19 in Iran was conducted for children 5-12 years on July 22, 2021, with PastoCovac and Sinopharm. This study aimed to evaluate the side effects following the administration of vaccines in children.
Methods: This descriptive-analytical study was performed on 394 children aged 5-12 years who were referred to health centers in Bojnurd, Iran, and received PastoCoVac or Sinopharm COVID-19 vaccines from March to July 2022. After receiving the first dose of the vaccine, in health centers, the children's parents filled out sections of a COVID-19 vaccine questionnaire that included sociodemographic and clinical characteristics of children. After that, other sections of the questionnaire related to side effects following vaccination were filled out by parents of children at different time intervals after receiving the first or second dose of vaccines.
Results: Our results showed that the incidence of vaccine side effects in children aged 5-12 years varies between 24%-37%, depending on the type and dose of vaccine. The most common side effects after getting the first and second doses of vaccines were injection site pain and swelling, fever, fatigue, and myalgia. No serious side effects were reported, and almost all side effects were resolved within a few days without special treatment.
Conclusion: It can be concluded that the incidence of side effects following COVID-19 vaccination in children aged 5-12 years varies depending on the type and dose of the vaccine. However, no serious side effects were reported, and most were resolved within a few days without special treatment. These findings suggest that the vaccination of children against COVID-19 is generally safe and well-tolerated.
کلیدواژه‌ها
injections,,؛ ,،fever,,؛ ,،fatigue,,؛ ,،myalgia
مراجع
  1. Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, Gulyaeva AA, Haagmans BL, Lauber C, Leontovich AM, Neuman BW, Penzar D, Perlman S, Poon LL, Samborskiy D, Sidorov IA, Sola I, Ziebuhr J. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nature Microbiology. 2020; 5(4):536-44.
  2. Salzberger B, Buder F, Lampl B, Ehrenstein B, Hatzenbichler F, Holzmann T, Schmidt B, Hanses F. Epidemiology of SARS-CoV-2. Infection. 2021; 49(2):233-9.
  3. Petrosillo N, Viceconte G, Ergonul O, Ippolito G, Petersen E. COVID-19, SARS and MERS: are they closely related? Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2020; 26(6):729-34.
  4. Edlow AG, Castro VM, Shook LL, Kaimal AJ, Perlis RH. Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 during Pregnancy. JAMA network open. 2022; 5(6):e2215787.
  5. Martins-Filho PR, Tanajura DM, Santos HP, Jr., Santos VS. COVID-19 during pregnancy: Potential risk for neurodevelopmental disorders in neonates? European journal of obstetrics, gynecology, and reproductive biology. 2020; 250:255-6.
  6. Ayed M, Embaireeg A, Kartam M, More K, Alqallaf M, AlNafisi A, Alsaffar Z, Bahzad Z, Buhamad Y, Alsayegh H, Al-Fouzan W, Alkandari H. Neurodevelopmental outcomes of infants born to mothers with SARS-CoV-2 infections during pregnancy: a national prospective study in Kuwait. BMC Pediatrics. 2022; 22(1):319.
  7. Abdoli A, Falahi S, Kenar Koohi A, Shams M, Mir H, Jahromi MAM. The COVID-19 pandemic, psychological stress during pregnancy, and risk of neurodevelopmental disorders in offspring: a neglected consequence. Journal of psychosomatic obstetrics and gynaecology. 2020; 41(3):247-8.
  8. Cao D, Yin H, Chen J, Tang F, Peng M, Li R, Xie H, Wei X, Zhao Y, Sun G. Clinical analysis of ten pregnant women with COVID-19 in Wuhan, China: A retrospective study. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases. 2020; 95:294-300.
  9. Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, Kang L, Guo L, Liu M, Zhou X, Luo J, Huang Z, Tu S, Zhao Y, Chen L, Xu D, Li Y, Li C, Peng L, Li Y, Xie W, Cui D, Shang L, Fan G, Xu J, Wang G, Wang Y, Zhong J, Wang C, Wang J, Zhang D, Cao B. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet (London, England). 2021; 397(10270):220-32.
  10. He J, Liu ZW, Lu YP, Li TY, Liang XJ, Arck PC, Huang SM, Hocher B, Chen YP. A Systematic Review and Meta-Analysis of Influenza A Virus Infection During Pregnancy Associated with an Increased Risk for Stillbirth and Low Birth Weight. Kidney & blood pressure research. 2017; 42(2):232-43.
  11. Shuffrey LC, Firestein MR, Kyle MH, Fields A, Alcántara C, Amso D, Austin J, Bain JM, Barbosa J, Bence M, Bianco C, Fernández CR, Goldman S, Gyamfi-Bannerman C, Hott V, Hu Y, Hussain M, Factor-Litvak P, Lucchini M, Mandel A, Marsh R, McBrian D, Mourad M, Muhle R, Noble KG, Penn AA, Rodriguez C, Sania A, Silver WG, O'Reilly KC, Stockwell M, Tottenham N, Welch MG, Zork N, Fifer WP, Monk C, Dumitriu D. Association of Birth During the COVID-19 Pandemic With Neurodevelopmental Status at 6 Months in Infants With and Without In Utero Exposure to Maternal SARS-CoV-2 Infection. JAMA pediatrics. 2022; 176(6):e215563.
  12. Sharma KS, Sharma R, Nehra S, Rajpurohit NA, Bhakar K, Kumar D. COVID-19: Consequences on pregnant women and neonates. Health Sciences Review. 2022; 4:100044.
  13. Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L. Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2021; 1867(10):166198.
  14. Racicot K, Mor G. Risks associated with viral infections during pregnancy. The Journal of Clinical Investigation. 2017; 127(5):1591-9.
  15. Littauer EQ, Skountzou I. Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection during Pregnancy. Frontiers in immunology. 2018; 9:2455.
  16. Papapanou M, Papaioannou M, Petta A, Routsi E, Farmaki M, Vlahos N, Siristatidis C. Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews. International journal of environmental research and public health. 2021; 18(2).
  17. Kirchengast S, Hartmann B. Pregnancy Outcome during the First COVID 19 Lockdown in Vienna, Austria. International journal of environmental research and public health. 2021; 18(7).
  18. Schwartz DA, Dhaliwal A. Coronavirus Diseases in Pregnant Women, the Placenta, Fetus, and Neonate. Advances in experimental medicine and biology. 2021; 1318:223-41.
  19. Kvestad I, Taneja S, Kumar T, Bhandari N, Strand TA, Hysing M. The assessment of developmental status using the Ages and Stages questionnaire-3 in nutritional research in north Indian young children. Nutrition Journal. 2013; 12(1):50.
  20. Singh A, Squires J, Yeh CJ, Heo KH, Bian H. Validity and reliability of the developmental assessment screening scale. Journal of family medicine and primary care. 2016; 5(1):124-8.
  21. Riemer HA, Chelladurai P. Development of the Athlete Satisfaction Questionnaire (ASQ). Journal of Sport and Exercise Psychology. 1998; 20(2):127-56.
  22. Romero Otalvaro AM, Grañana N, Gaeto N, Torres M, Zamblera MN, Vasconez MA, Misenta C, Rouvier ME, Squires J. ASQ-3: Validation of the Ages and Stages Questionnaire for the detection of neurodevelopmental disorders in Argentine children. Archivos argentinos de pediatría. 2018; 116(1):7-13.
  23. Chong KC, Zhou VL, Tarazona D, Tuesta H, Velásquez-Hurtado JE, Sadeghi R, Llanos F. ASQ-3 scores are sensitive to small differences in age in a Peruvian infant population. Child: care, health and development. 2017; 43(4):556-65.
  24. Piekos SN, Roper RT, Hwang YM, Sorensen T, Price ND, Hood L, Hadlock JJ. The effect of maternal SARS-CoV-2 infection timing on birth outcomes: a retrospective multicentre cohort study. The Lancet Digital health. 2022; 4(2):e95-e104.
  25. Capretti MG, Marsico C, Gabrielli L, Vocale C, Arcuri's, Simonazzi G, Piccinini AR, Brandolini C, Lazzarotto T, Corvaglia LT. Infants Born Following SARS-CoV-2 Infection in Pregnancy. Pediatrics. 2022; 150(5).
  26. Zlatkin R, Dollinger S, Jacoby C, Shmueli A, Barbash-Hazan S, Chen R, Wiznitzer A, Hadar E. Obstetric and perinatal outcomes in parturients with active SARS-CoV-2 infection during labor and delivery: a retrospective cohort study. BMC Pregnancy and Childbirth. 2022; 22(1):511.
  27. Morán Antolín E, Broullón Molanes JR, de la Cruz Conty ML, Encinas Pardilla MB, Guadix Martín MDP, Sainz Bueno JA, Acebal LF, Recarte PP, Bartolomé AA, Martínez Cendán JP, Martínez-Pérez Ó, On Behalf Of The Spanish Obstetric Emergency Group. SARS-CoV-2 Infection and C-Section: A Prospective Observational Study. Viruses. 2021; 13(11).
  28. Robaina-Castellanos GR, Riesgo-Rodríguez SC. Congenital and Intrapartum SARS-CoV-2 Infection in Neonates: Hypotheses, Evidence and Perspectives. MEDICC review. 2021; 23(1):72-83.
  29. Chen L, Li Q, Zheng D, Jiang H, Wei Y, Zou L, Feng L, Xiong G, Sun G, Wang H, Zhao Y, Qiao J. Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China. The New England Journal of medicine. 2020; 382(25):e100.
  30. Mullins E, Hudak ML, Banerjee J, Getzlaff T, Townson J, Barnette K, Playle R, Perry A, Bourne T, Lees CC; PAN-COVID investigators and the National Perinatal COVID-19 Registry Study Group. Pregnancy and neonatal outcomes of COVID-19: coreporting of common outcomes from PAN-COVID and AAP-SONPM registries. Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2021; 57(4):573-81.
  31. Mark EG, McAleese S, Golden WC, Gilmore MM, Sick-Samuels A, Curless MS, Nogee LM, Milstone AM, Johnson J. Coronavirus Disease 2019 in Pregnancy and Outcomes Among Pregnant Women and Neonates: A Literature Review. The Pediatric infectious disease journal. 2021; 40(5):473-8.
  32. Engjom H, Aabakke AJM, Klungsøyr K, Svanvik T, Äyräs O, Jonasdottir E, Thurn L, Jones E, Pettersson K, Nyfløt LT, Al-Zirqi I, Vangen S, Júlíusson PB, Källén K, Gissler M, Krebs L. COVID-19 in pregnancy-characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries. Acta obstetricia et gynecologica Scandinavica. 2021; 100(9):1611-9.
  33. McClymont E, Albert AY, Alton GD, Boucoiran I, Castillo E, Fell DB, Kuret V, Poliquin V, Reeve T, Scott H, Sprague AE, Carson G, Cassell K, Crane J, Elwood C, Joynt C, Murphy P, Murphy-Kaulbeck L, Saunders S, Shah P, Snelgrove JW, Schalkwyk Jv, Yudin MH, Money D, CANCOVID-Preg Team. Association of SARS-CoV-2 Infection during Pregnancy with Maternal and Perinatal Outcomes. JAMA. 2022; 327(20):1983-91.
  34. Yang R, Mei H, Zheng T, Fu Q, Zhang Y, Buka S, Yao X, Tang Z, Zhang X, Qiu L, Zhang Y, Zhou J, Cao J, Wang Y, Zhou A. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Medicine. 2020; 18(1):330.
  35. Dileep A, ZainAlAbdin S, AbuRuz S. Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes. Scientific reports. 2022; 12(1):3024.
  36. Huang P, Zhou F, Guo Y, Yuan S, Lin S, Lu J, Tu S, Lu M, Shen S, Guedeney A, Xia H, Qiu X. Association Between the COVID-19 Pandemic and Infant Neurodevelopment: A Comparison Before and During COVID-19. Frontiers in Pediatrics. 2021; 9.
  37. Munian D, Das R, Hazra A, Ray S. Outcome of Neonates Born to COVID-Positive Women at 6 Months of Age. Indian pediatrics. 2021; 58(9):853-6.
  38. Cheng Y, Teng H, Xiao Y, Yao M, Yin J, Sun G. Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study. Frontiers in Pediatrics. 2021; 9.
  39. Tanacan A, Yazihan N, Erol SA, Anuk AT, Yucel Yetiskin FD, Biriken D, Ozgu-Erdinc AS, Keskin HL, Tekin OM, Sahin D. The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study. Cytokine. 2021; 140:155431.
  40. Solek CM, Farooqi N, Verly M, Lim TK, Ruthazer ES. Maternal immune activation in neurodevelopmental disorders. Developmental dynamics: an official publication of the American Association of Anatomists. 2018; 247(4):588-619.
  41. Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain development through interleukin-6. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2007; 27(40):10695-702.
  42. Cordeiro CN, Tsimis M, Burd I. Infections and Brain Development. Obstetrical & gynecological survey. 2015; 70(10):644-55.
  43. Khandaker GM, Zimbron J, Lewis G, Jones PB. Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychological medicine. 2013; 43(2):239-57.
  44. Fitzgerald E, Hor K, Drake AJ. Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences. Early human development. 2020; 150:105190.
  45. Hilaire M, Andrianou XD, Lenglet A, Ariti C, Charles K, Buitenhuis S, Brusselen DV, Roggeveen H, Ledger E, Denat RS, Bryson L. Growth and neurodevelopment in low birth weight versus normal birth weight infants from birth to 24 months, born in an obstetric emergency hospital in Haiti, a prospective cohort study. BMC Pediatrics. 2021; 21(1):143.
  46. Scharf RJ, Stroustrup A, Conaway MR, DeBoer MD. Growth and development in children born with a very low birthweight. Archives of disease in childhood Fetal and neonatal edition. 2016; 101(5):F433-8.
آمار
تعداد مشاهده مقاله: 389
تعداد دریافت فایل اصل مقاله: 262