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Namakin, Kokab, Saadatinasab, Zohre, Salehiniya, Hamid, Zardast, Amirhosein. (1402). Comparing the Growth and Development of Six Months Infants between the Mothers With/Without Covid-19 during Their Pregnancy. , 11(4), 17558-17571. doi: 10.22038/ijp.2023.69768.5148
Kokab Namakin; Zohre Saadatinasab; Hamid Salehiniya; Amirhosein Zardast. "Comparing the Growth and Development of Six Months Infants between the Mothers With/Without Covid-19 during Their Pregnancy". , 11, 4, 1402, 17558-17571. doi: 10.22038/ijp.2023.69768.5148
Namakin, Kokab, Saadatinasab, Zohre, Salehiniya, Hamid, Zardast, Amirhosein. (1402). 'Comparing the Growth and Development of Six Months Infants between the Mothers With/Without Covid-19 during Their Pregnancy', , 11(4), pp. 17558-17571. doi: 10.22038/ijp.2023.69768.5148
Namakin, Kokab, Saadatinasab, Zohre, Salehiniya, Hamid, Zardast, Amirhosein. Comparing the Growth and Development of Six Months Infants between the Mothers With/Without Covid-19 during Their Pregnancy. , 1402; 11(4): 17558-17571. doi: 10.22038/ijp.2023.69768.5148

Comparing the Growth and Development of Six Months Infants between the Mothers With/Without Covid-19 during Their Pregnancy

International Journal of Pediatrics
مقاله 2، دوره 11، شماره 4، تیر 2023، صفحه 17558-17571    اصل مقاله (327.06 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2023.69768.5148
نویسندگان
Kokab Namakin1؛ Zohre Saadatinasab* 2؛ Hamid Salehiniya3؛ Amirhosein Zardast4
1Professor of pediatrics
2Department of Pediatrics, Birjand University of Medical Sciences, Birjand, Iran.
3tehran university of medical sciences
4Student research committee of Mashhad university of medical sciences
چکیده
Background: Viral infection during pregnancy induces pro-inflammatory cytokines and increases the level of IL-6, which as a measure of the inflammation of the mother's immune system is effective on the development of the brain of the fetus and increases the rate of mental disorders of the fetus. The possible effect of the mother's COVID-19 on children, if any, is still unknown. Therefore, this study was conducted with the aim of investigating and comparing the consequences of neurodevelopment and growth at the age of 6 months in infants among mothers with/without exposure to COVID-19 during pregnancy in Birjand, 2021.
Methods: A total of 161 pregnant women with PCR-positive coronavirus and 181 pregnant women without infection were selected by simple random sampling. Demographic characteristics including age, occupation, education, gender, nationality, sex of babies, along with data related to the neurodevelopmental status of infants by the use of ASQ questionnaire were extracted and entered into SPSS 16 software. For descriptive statistics, Mean, standard deviation, and frequency distribution tables were used, and inferential analyses were conducted by the use of Chi-square, t-test, and analysis of variance at a significance level of less than 0.05. The disturbance was equal / lower than 1 SD in each of ASQ-3 score domains.
Results: In this cohort study, demographic characteristics in the exposed and unexposed groups were not significantly different. There was no statistically significant difference between the average score of the ASQ_3 questionnaires as well as the average score in the areas of communication, gross motor, fine motor, problem-solving, and social personality among infants born from mothers with and without COVID-19. Also, there was no significant difference in the incidence of disorders in different fields of neurodevelopment, except for the field of establishing communication between the two groups of exposed and unexposed. On the other hand, cesarean delivery was significantly higher in pregnant mothers with COVID-19 during pregnancy. However, there was no significant relationship between the incidence of COVID-19 and the rate of premature delivery, and low birth weight neonates. In addition, the severity and time of the corona infection during pregnancy did not have any significant effect on the neurodevelopment of infants with intrauterine exposure to COVID-19.
Conclusion: According to the results of the study, infection with COVID-19 does not increase the incidence of developmental disorders in 6-month-old infants. Furthermore, it does not increase low 
کلیدواژه‌ها
Frequency,,؛ ,،Neurodevelopment,,؛ ,،COVID-19,,؛ ,،Pregnancy,,؛ ,،ASQ-3 questionnaire
مراجع
  1. Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, Gulyaeva AA, Haagmans BL, Lauber C, Leontovich AM, Neuman BW, Penzar D, Perlman S, Poon LL, Samborskiy D, Sidorov IA, Sola I, Ziebuhr J. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nature Microbiology. 2020; 5(4):536-44.
  2. Salzberger B, Buder F, Lampl B, Ehrenstein B, Hatzenbichler F, Holzmann T, Schmidt B, Hanses F. Epidemiology of SARS-CoV-2. Infection. 2021; 49(2):233-9.
  3. Petrosillo N, Viceconte G, Ergonul O, Ippolito G, Petersen E. COVID-19, SARS and MERS: are they closely related? Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2020; 26(6):729-34.
  4. Edlow AG, Castro VM, Shook LL, Kaimal AJ, Perlis RH. Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 during Pregnancy. JAMA network open. 2022; 5(6):e2215787.
  5. Martins-Filho PR, Tanajura DM, Santos HP, Jr., Santos VS. COVID-19 during pregnancy: Potential risk for neurodevelopmental disorders in neonates? European journal of obstetrics, gynecology, and reproductive biology. 2020; 250:255-6.
  6. Ayed M, Embaireeg A, Kartam M, More K, Alqallaf M, AlNafisi A, Alsaffar Z, Bahzad Z, Buhamad Y, Alsayegh H, Al-Fouzan W, Alkandari H. Neurodevelopmental outcomes of infants born to mothers with SARS-CoV-2 infections during pregnancy: a national prospective study in Kuwait. BMC Pediatrics. 2022; 22(1):319.
  7. Abdoli A, Falahi S, Kenar Koohi A, Shams M, Mir H, Jahromi MAM. The COVID-19 pandemic, psychological stress during pregnancy, and risk of neurodevelopmental disorders in offspring: a neglected consequence. Journal of psychosomatic obstetrics and gynaecology. 2020; 41(3):247-8.
  8. Cao D, Yin H, Chen J, Tang F, Peng M, Li R, Xie H, Wei X, Zhao Y, Sun G. Clinical analysis of ten pregnant women with COVID-19 in Wuhan, China: A retrospective study. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases. 2020; 95:294-300.
  9. Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, Kang L, Guo L, Liu M, Zhou X, Luo J, Huang Z, Tu S, Zhao Y, Chen L, Xu D, Li Y, Li C, Peng L, Li Y, Xie W, Cui D, Shang L, Fan G, Xu J, Wang G, Wang Y, Zhong J, Wang C, Wang J, Zhang D, Cao B. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet (London, England). 2021; 397(10270):220-32.
  10. He J, Liu ZW, Lu YP, Li TY, Liang XJ, Arck PC, Huang SM, Hocher B, Chen YP. A Systematic Review and Meta-Analysis of Influenza A Virus Infection During Pregnancy Associated with an Increased Risk for Stillbirth and Low Birth Weight. Kidney & blood pressure research. 2017; 42(2):232-43.
  11. Shuffrey LC, Firestein MR, Kyle MH, Fields A, Alcántara C, Amso D, Austin J, Bain JM, Barbosa J, Bence M, Bianco C, Fernández CR, Goldman S, Gyamfi-Bannerman C, Hott V, Hu Y, Hussain M, Factor-Litvak P, Lucchini M, Mandel A, Marsh R, McBrian D, Mourad M, Muhle R, Noble KG, Penn AA, Rodriguez C, Sania A, Silver WG, O'Reilly KC, Stockwell M, Tottenham N, Welch MG, Zork N, Fifer WP, Monk C, Dumitriu D. Association of Birth During the COVID-19 Pandemic With Neurodevelopmental Status at 6 Months in Infants With and Without In Utero Exposure to Maternal SARS-CoV-2 Infection. JAMA pediatrics. 2022; 176(6):e215563.
  12. Sharma KS, Sharma R, Nehra S, Rajpurohit NA, Bhakar K, Kumar D. COVID-19: Consequences on pregnant women and neonates. Health Sciences Review. 2022; 4:100044.
  13. Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L. Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2021; 1867(10):166198.
  14. Racicot K, Mor G. Risks associated with viral infections during pregnancy. The Journal of Clinical Investigation. 2017; 127(5):1591-9.
  15. Littauer EQ, Skountzou I. Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection during Pregnancy. Frontiers in immunology. 2018; 9:2455.
  16. Papapanou M, Papaioannou M, Petta A, Routsi E, Farmaki M, Vlahos N, Siristatidis C. Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews. International journal of environmental research and public health. 2021; 18(2).
  17. Kirchengast S, Hartmann B. Pregnancy Outcome during the First COVID 19 Lockdown in Vienna, Austria. International journal of environmental research and public health. 2021; 18(7).
  18. Schwartz DA, Dhaliwal A. Coronavirus Diseases in Pregnant Women, the Placenta, Fetus, and Neonate. Advances in experimental medicine and biology. 2021; 1318:223-41.
  19. Kvestad I, Taneja S, Kumar T, Bhandari N, Strand TA, Hysing M. The assessment of developmental status using the Ages and Stages questionnaire-3 in nutritional research in north Indian young children. Nutrition Journal. 2013; 12(1):50.
  20. Singh A, Squires J, Yeh CJ, Heo KH, Bian H. Validity and reliability of the developmental assessment screening scale. Journal of family medicine and primary care. 2016; 5(1):124-8.
  21. Riemer HA, Chelladurai P. Development of the Athlete Satisfaction Questionnaire (ASQ). Journal of Sport and Exercise Psychology. 1998; 20(2):127-56.
  22. Romero Otalvaro AM, Grañana N, Gaeto N, Torres M, Zamblera MN, Vasconez MA, Misenta C, Rouvier ME, Squires J. ASQ-3: Validation of the Ages and Stages Questionnaire for the detection of neurodevelopmental disorders in Argentine children. Archivos argentinos de pediatría. 2018; 116(1):7-13.
  23. Chong KC, Zhou VL, Tarazona D, Tuesta H, Velásquez-Hurtado JE, Sadeghi R, Llanos F. ASQ-3 scores are sensitive to small differences in age in a Peruvian infant population. Child: care, health and development. 2017; 43(4):556-65.
  24. Piekos SN, Roper RT, Hwang YM, Sorensen T, Price ND, Hood L, Hadlock JJ. The effect of maternal SARS-CoV-2 infection timing on birth outcomes: a retrospective multicentre cohort study. The Lancet Digital health. 2022; 4(2):e95-e104.
  25. Capretti MG, Marsico C, Gabrielli L, Vocale C, Arcuri's, Simonazzi G, Piccinini AR, Brandolini C, Lazzarotto T, Corvaglia LT. Infants Born Following SARS-CoV-2 Infection in Pregnancy. Pediatrics. 2022; 150(5).
  26. Zlatkin R, Dollinger S, Jacoby C, Shmueli A, Barbash-Hazan S, Chen R, Wiznitzer A, Hadar E. Obstetric and perinatal outcomes in parturients with active SARS-CoV-2 infection during labor and delivery: a retrospective cohort study. BMC Pregnancy and Childbirth. 2022; 22(1):511.
  27. Morán Antolín E, Broullón Molanes JR, de la Cruz Conty ML, Encinas Pardilla MB, Guadix Martín MDP, Sainz Bueno JA, Acebal LF, Recarte PP, Bartolomé AA, Martínez Cendán JP, Martínez-Pérez Ó, On Behalf Of The Spanish Obstetric Emergency Group. SARS-CoV-2 Infection and C-Section: A Prospective Observational Study. Viruses. 2021; 13(11).
  28. Robaina-Castellanos GR, Riesgo-Rodríguez SC. Congenital and Intrapartum SARS-CoV-2 Infection in Neonates: Hypotheses, Evidence and Perspectives. MEDICC review. 2021; 23(1):72-83.
  29. Chen L, Li Q, Zheng D, Jiang H, Wei Y, Zou L, Feng L, Xiong G, Sun G, Wang H, Zhao Y, Qiao J. Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China. The New England Journal of medicine. 2020; 382(25):e100.
  30. Mullins E, Hudak ML, Banerjee J, Getzlaff T, Townson J, Barnette K, Playle R, Perry A, Bourne T, Lees CC; PAN-COVID investigators and the National Perinatal COVID-19 Registry Study Group. Pregnancy and neonatal outcomes of COVID-19: coreporting of common outcomes from PAN-COVID and AAP-SONPM registries. Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2021; 57(4):573-81.
  31. Mark EG, McAleese S, Golden WC, Gilmore MM, Sick-Samuels A, Curless MS, Nogee LM, Milstone AM, Johnson J. Coronavirus Disease 2019 in Pregnancy and Outcomes Among Pregnant Women and Neonates: A Literature Review. The Pediatric infectious disease journal. 2021; 40(5):473-8.
  32. Engjom H, Aabakke AJM, Klungsøyr K, Svanvik T, Äyräs O, Jonasdottir E, Thurn L, Jones E, Pettersson K, Nyfløt LT, Al-Zirqi I, Vangen S, Júlíusson PB, Källén K, Gissler M, Krebs L. COVID-19 in pregnancy-characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries. Acta obstetricia et gynecologica Scandinavica. 2021; 100(9):1611-9.
  33. McClymont E, Albert AY, Alton GD, Boucoiran I, Castillo E, Fell DB, Kuret V, Poliquin V, Reeve T, Scott H, Sprague AE, Carson G, Cassell K, Crane J, Elwood C, Joynt C, Murphy P, Murphy-Kaulbeck L, Saunders S, Shah P, Snelgrove JW, Schalkwyk Jv, Yudin MH, Money D, CANCOVID-Preg Team. Association of SARS-CoV-2 Infection during Pregnancy with Maternal and Perinatal Outcomes. JAMA. 2022; 327(20):1983-91.
  34. Yang R, Mei H, Zheng T, Fu Q, Zhang Y, Buka S, Yao X, Tang Z, Zhang X, Qiu L, Zhang Y, Zhou J, Cao J, Wang Y, Zhou A. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Medicine. 2020; 18(1):330.
  35. Dileep A, ZainAlAbdin S, AbuRuz S. Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes. Scientific reports. 2022; 12(1):3024.
  36. Huang P, Zhou F, Guo Y, Yuan S, Lin S, Lu J, Tu S, Lu M, Shen S, Guedeney A, Xia H, Qiu X. Association Between the COVID-19 Pandemic and Infant Neurodevelopment: A Comparison Before and During COVID-19. Frontiers in Pediatrics. 2021; 9.
  37. Munian D, Das R, Hazra A, Ray S. Outcome of Neonates Born to COVID-Positive Women at 6 Months of Age. Indian pediatrics. 2021; 58(9):853-6.
  38. Cheng Y, Teng H, Xiao Y, Yao M, Yin J, Sun G. Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study. Frontiers in Pediatrics. 2021; 9.
  39. Tanacan A, Yazihan N, Erol SA, Anuk AT, Yucel Yetiskin FD, Biriken D, Ozgu-Erdinc AS, Keskin HL, Tekin OM, Sahin D. The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study. Cytokine. 2021; 140:155431.
  40. Solek CM, Farooqi N, Verly M, Lim TK, Ruthazer ES. Maternal immune activation in neurodevelopmental disorders. Developmental dynamics: an official publication of the American Association of Anatomists. 2018; 247(4):588-619.
  41. Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain development through interleukin-6. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2007; 27(40):10695-702.
  42. Cordeiro CN, Tsimis M, Burd I. Infections and Brain Development. Obstetrical & gynecological survey. 2015; 70(10):644-55.
  43. Khandaker GM, Zimbron J, Lewis G, Jones PB. Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychological medicine. 2013; 43(2):239-57.
  44. Fitzgerald E, Hor K, Drake AJ. Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences. Early human development. 2020; 150:105190.
  45. Hilaire M, Andrianou XD, Lenglet A, Ariti C, Charles K, Buitenhuis S, Brusselen DV, Roggeveen H, Ledger E, Denat RS, Bryson L. Growth and neurodevelopment in low birth weight versus normal birth weight infants from birth to 24 months, born in an obstetric emergency hospital in Haiti, a prospective cohort study. BMC Pediatrics. 2021; 21(1):143.
  46. Scharf RJ, Stroustrup A, Conaway MR, DeBoer MD. Growth and development in children born with a very low birthweight. Archives of disease in childhood Fetal and neonatal edition. 2016; 101(5):F433-8.
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