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Bahadorian, Davood, Mollazadeh, Samaneh, Mirazi, Hosein, Faraj, Tola, Kheder, Ramiar, Esmaeili, Seyed-Alireza. (1402). Regulatory NK cells in autoimmune disease. , 26(6), 609-616. doi: 10.22038/ijbms.2023.68653.14969
Davood Bahadorian; Samaneh Mollazadeh; Hosein Mirazi; Tola Abdulsattar Faraj; Ramiar Kamal Kheder; Seyed-Alireza Esmaeili. "Regulatory NK cells in autoimmune disease". , 26, 6, 1402, 609-616. doi: 10.22038/ijbms.2023.68653.14969
Bahadorian, Davood, Mollazadeh, Samaneh, Mirazi, Hosein, Faraj, Tola, Kheder, Ramiar, Esmaeili, Seyed-Alireza. (1402). 'Regulatory NK cells in autoimmune disease', , 26(6), pp. 609-616. doi: 10.22038/ijbms.2023.68653.14969
Bahadorian, Davood, Mollazadeh, Samaneh, Mirazi, Hosein, Faraj, Tola, Kheder, Ramiar, Esmaeili, Seyed-Alireza. Regulatory NK cells in autoimmune disease. , 1402; 26(6): 609-616. doi: 10.22038/ijbms.2023.68653.14969

Regulatory NK cells in autoimmune disease

Iranian Journal of Basic Medical Sciences
مقاله 1، دوره 26، شماره 6، شهریور 2023، صفحه 609-616    اصل مقاله (835.06 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.68653.14969
نویسندگان
Davood Bahadorian1؛ Samaneh Mollazadeh2؛ Hosein Mirazi3؛ Tola Abdulsattar Faraj4، 5؛ Ramiar Kamal Kheder6، 5؛ Seyed-Alireza Esmaeili* 1، 7
1Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
3Department of Biomedical Engineering, Faculty of New Sciences and Technology, University of Tehran, Tehran, Iran
4Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq
5Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil, Iraq
6Medical Laboratory Science Department, College of Science, University of Raparin, Rania, Sulaymaniyah, Iraq
7Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
NK cells are defined as the major components of the immunological network which exerts defense against tumors and viral infections as well as regulation of innate and adaptive immunity, shaped through interaction with other cells like T cells. According to the surface markers, NK cells can be divided into CD56dim NK and CD56bright NK subsets. CD56bright NK cells usually are known as regulatory NK cells. Once the immune system loses its self-tolerance, autoimmune diseases develop. NK cells and their subsets can be altered during autoimmune diseases, indicative of their prominent regulatory roles and even pathological and protective functions in autoimmune disorders. In this regard, activation of CD56bright NK cells can suppress activated autologous CD4+ T cells and subsequently prevent the initiation of autoimmunity. In this review article, we summarize the roles of regulatory NK cells in autoimmune disease occurrence which needs more research to uncover their exact related mechanism. It seems that targeting NK cells can be a promising therapeutic platform against autoimmune diseases.
کلیدواژه‌ها
Autoimmune disease؛ CD56bright NK cell؛ Cytokine؛ Immunology؛ Regulatory NK cell
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