سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Hedayatyanfard, Keshvad, Khalili, Azadeh, Karim, Hosein, Nooraei, Soren, Khosravi, Ehsan, Sadat Haddadi, Nazgol, Dehpour, Ahmad Reza, Bayat, Gholamreza. (1402). Potential use of angiotensin receptor blockers in skin pathologies. , 26(7), 732-737. doi: 10.22038/ijbms.2023.66563.14606
Keshvad Hedayatyanfard; Azadeh Khalili; Hosein Karim; Soren Nooraei; Ehsan Khosravi; Nazgol Sadat Haddadi; Ahmad Reza Dehpour; Gholamreza Bayat. "Potential use of angiotensin receptor blockers in skin pathologies". , 26, 7, 1402, 732-737. doi: 10.22038/ijbms.2023.66563.14606
Hedayatyanfard, Keshvad, Khalili, Azadeh, Karim, Hosein, Nooraei, Soren, Khosravi, Ehsan, Sadat Haddadi, Nazgol, Dehpour, Ahmad Reza, Bayat, Gholamreza. (1402). 'Potential use of angiotensin receptor blockers in skin pathologies', , 26(7), pp. 732-737. doi: 10.22038/ijbms.2023.66563.14606
Hedayatyanfard, Keshvad, Khalili, Azadeh, Karim, Hosein, Nooraei, Soren, Khosravi, Ehsan, Sadat Haddadi, Nazgol, Dehpour, Ahmad Reza, Bayat, Gholamreza. Potential use of angiotensin receptor blockers in skin pathologies. , 1402; 26(7): 732-737. doi: 10.22038/ijbms.2023.66563.14606

Potential use of angiotensin receptor blockers in skin pathologies

Iranian Journal of Basic Medical Sciences
مقاله 2، دوره 26، شماره 7، مهر 2023، صفحه 732-737    اصل مقاله (265.75 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.66563.14606
نویسندگان
Keshvad Hedayatyanfard1، 2؛ Azadeh Khalili1؛ Hosein Karim2، 3؛ Soren Nooraei4؛ Ehsan Khosravi5؛ Nazgol Sadat Haddadi6؛ Ahmad Reza Dehpour7؛ Gholamreza Bayat* 1
1Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
2Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
3Department of Cardiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
4Student of School of Veterinary Medicine, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran
5Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
6Department of Dermatology, University of Massachusetts School of Medicine, Worchester, MA, USA
7Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT1R and AT2R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT1R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis, proliferation, and migration of immune cells to the skin. In contrast, AT2R suppresses the effects mentioned above. Many studies show that angiotensin receptor blockers (ARBs) and angiotensin-converting enzymes (ACEi) reduce the proinflammatory cytokines and fibrogenic factors including transforming growth factor β (TGF-β), Connective tissue growth factor (CTGF), and IL-6. This review article provides a detailed research study on the implications of ARBs in wound healing, hypertrophic scar, and keloids. We further discuss the therapeutic potentials of ARBs in autoimmune and autoinflammatory skin diseases and cancer, given their anti-fibrotic and anti-inflammatory effects.
کلیدواژه‌ها
Angiotensin II؛ Cancer؛ Keloid؛ Scar؛ Skin disease؛ Wound healing
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