سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Liu, Meng, Zeng, Mengnan, Guo, Pengli, Zhang, Yuhan, Yang, Xiaofeng, Jia, Jufang, Zhang, Qinqin, Zhang, Beibei, Cao, Bing, Wang, Ru, Zheng, Xiaoke, Feng, Weisheng. (1402). Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway. , 26(5), 579-586. doi: 10.22038/ijbms.2023.67322.14757
Meng Liu; Mengnan Zeng; Pengli Guo; Yuhan Zhang; Xiaofeng Yang; Jufang Jia; Qinqin Zhang; Beibei Zhang; Bing Cao; Ru Wang; Xiaoke Zheng; Weisheng Feng. "Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway". , 26, 5, 1402, 579-586. doi: 10.22038/ijbms.2023.67322.14757
Liu, Meng, Zeng, Mengnan, Guo, Pengli, Zhang, Yuhan, Yang, Xiaofeng, Jia, Jufang, Zhang, Qinqin, Zhang, Beibei, Cao, Bing, Wang, Ru, Zheng, Xiaoke, Feng, Weisheng. (1402). 'Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway', , 26(5), pp. 579-586. doi: 10.22038/ijbms.2023.67322.14757
Liu, Meng, Zeng, Mengnan, Guo, Pengli, Zhang, Yuhan, Yang, Xiaofeng, Jia, Jufang, Zhang, Qinqin, Zhang, Beibei, Cao, Bing, Wang, Ru, Zheng, Xiaoke, Feng, Weisheng. Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway. , 1402; 26(5): 579-586. doi: 10.22038/ijbms.2023.67322.14757

Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway

Iranian Journal of Basic Medical Sciences
مقاله 12، دوره 26، شماره 5، مرداد 2023، صفحه 579-586    اصل مقاله (949.16 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.67322.14757
نویسندگان
Meng Liu1، 2؛ Mengnan Zeng1، 2؛ Pengli Guo1، 2؛ Yuhan Zhang1، 2؛ Xiaofeng Yang1، 2؛ Jufang Jia1، 2؛ Qinqin Zhang1، 2؛ Beibei Zhang1، 2؛ Bing Cao1، 2؛ Ru Wang1، 2؛ Xiaoke Zheng1، 2؛ Weisheng Feng* 1، 2
1Department of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China
2The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
چکیده
Objective(s): To explore the effects and mechanism of three types of fresh Rehmannia glutinosa, namely Beijing No. 3 (BJ3H), Huaizhong No. 1 (HZ1H), and Taisheng (TS) on lipopolysaccharide (LPS)-induced acute kidney injury in the sepsis (S-AKI) mice model through the estrogen receptor pathway.
Materials and Methods: BALB/c mice were randomly divided into control (CON), model (LPS), astragalus injection (ASI), BJ3H, HZ1H, TS water extract groups, the estrogen receptor antagonist ICI182,780 groups were added to each group. The antagonist groups received an intraperitoneal injection of ICI 0.5 hr before administration and an intraperitoneal injection of LPS 3 days after administration. The kidney pathology, function, inflammatory factors, immune cells, levels of reactive oxygen species (ROS), apoptosis, and the protein expression levels of TLR4/NF-κB/NLRP3 signaling pathway in the mice kidneys were detected.
Results: ASI, BJ3H, HZ1H, and TS improved LPS-induced renal pathology in S-AKI mice, reduced the kidney and serum levels of inflammatory factors, positive rates of macrophages and neutrophils, levels of ROS and apoptosis, and the relative expression levels of TLR4, MyD88, NF-κB p-p65/NF-κB p65, and NLRP3 proteins in the kidney. In addition, they increased the positive rate of dendritic cells (DCs) in the mice kidneys. The overall effect of HZ1H was superior to that of ASI, BJ3H, and TS. However, after adding ICI, the regulatory effects of drugs were inhibited.
Conclusion: The three types of fresh R. glutinosa may completely or partially affect the TLR4/NF-κB/NLRP3 signaling pathway through the estrogen receptor pathway to exert a protective effect on S-AKI.
کلیدواژه‌ها
Acute kidney injury؛ Estrogen؛ Fresh Rehmannia glutinosa؛ Lipopolysaccharide؛ NF-kappa B؛ NLRP3؛ Sepsis؛ TLR4
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