Rezaei, Shiva, Hosseinimehr, Seyed Jalal, Zargari, Mehryar, Karimpour Malekshah, Abbasali, Mirzaei, Mansooreh, Talebpour Amiri, Fereshteh. (1402). Sinapic acid attenuates cyclophosphamide-induced liver toxicity in mice by modulating oxidative stress, NF-κB, and caspase-3. , 26(5), 526-531. doi: 10.22038/ijbms.2023.68579.14960
Shiva Rezaei; Seyed Jalal Hosseinimehr; Mehryar Zargari; Abbasali Karimpour Malekshah; Mansooreh Mirzaei; Fereshteh Talebpour Amiri. "Sinapic acid attenuates cyclophosphamide-induced liver toxicity in mice by modulating oxidative stress, NF-κB, and caspase-3". , 26, 5, 1402, 526-531. doi: 10.22038/ijbms.2023.68579.14960
Rezaei, Shiva, Hosseinimehr, Seyed Jalal, Zargari, Mehryar, Karimpour Malekshah, Abbasali, Mirzaei, Mansooreh, Talebpour Amiri, Fereshteh. (1402). 'Sinapic acid attenuates cyclophosphamide-induced liver toxicity in mice by modulating oxidative stress, NF-κB, and caspase-3', , 26(5), pp. 526-531. doi: 10.22038/ijbms.2023.68579.14960
Rezaei, Shiva, Hosseinimehr, Seyed Jalal, Zargari, Mehryar, Karimpour Malekshah, Abbasali, Mirzaei, Mansooreh, Talebpour Amiri, Fereshteh. Sinapic acid attenuates cyclophosphamide-induced liver toxicity in mice by modulating oxidative stress, NF-κB, and caspase-3. , 1402; 26(5): 526-531. doi: 10.22038/ijbms.2023.68579.14960

Sinapic acid attenuates cyclophosphamide-induced liver toxicity in mice by modulating oxidative stress, NF-κB, and caspase-3

Iranian Journal of Basic Medical Sciences
مقاله 5، دوره 26، شماره 5، مرداد 2023، صفحه 526-531    اصل مقاله (500.21 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.68579.14960
نویسندگان
Shiva Rezaei1، 2؛ Seyed Jalal Hosseinimehr3؛ Mehryar Zargari4؛ Abbasali Karimpour Malekshah1؛ Mansooreh Mirzaei1؛ Fereshteh Talebpour Amiri* 1
1Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
4Department of Biochemistry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Objective(s): Cyclophosphamide (CP) as an antineoplastic drug is widely used in cancer patients, and liver toxicity is one of its complications. Sinapic acid (SA) as a natural phenylpropanoid has anti-oxidant, anti-inflammatory, and anti-cancer properties.
Materials and Methods: The purpose of the current study was to determine the protective effect of SA versus CP-induced liver toxicity. In this research, BALB/c mice were treated with SA (5 and 10 mg/kg) orally for one week, and CP (200 mg/kg) was injected on day 3 of the study. Oxidative stress markers, serum liver-specific enzymes, histopathological features, caspase-3, and nuclear factor kappa-B cells were then checked.
Results: CP induced hepatotoxicity in mice and showed structural changes in liver tissue. CP significantly increased liver enzymes and lipid peroxidation, and decreased glutathione. The immunoreactivity of caspase-3 and nuclear factor kappa-B cells was significantly increased. Administration of SA significantly maintained histochemical parameters and liver function enzymes in mice treated with CP. Immunohistochemical examination showed SA reduced apoptosis and inflammation. 
Conclusion: The data confirmed that SA with anti-apoptotic, anti-oxidative, and anti-inflammatory activities was able to preserve CP-induced liver injury in mice. 
کلیدواژه‌ها
Apoptosis؛ Cyclophosphamide؛ Liver injury؛ Inflammation؛ Oxidative stress؛ Sinapic acid
مراجع
آمار
تعداد مشاهده مقاله: 894
تعداد دریافت فایل اصل مقاله: 781