Fazeli, Mostafa, Moslem, Ali Reza, Meshkat, Zahra, Timar, Ameneh, Tabatabaeizadeh, Seyed-Amir, Ghazizadeh, Hamideh, Ghaffarian Zirak, Roshanak, Moghbeli, Meysam, Boroumand, Nadia, jaberi, Naghme, Mohammadzadeh, Mohammad, Ferns, Gordon A., Bahrami, Hamid Reza, Ghayour-mobarhan, Majid. (1401). The Association between Red Blood Cell Distribution Width and Metabolic Syndrome in Adolescent Girls. , 11(2), 17416-17427. doi: 10.22038/ijp.2023.60826.4692
Mostafa Fazeli; Ali Reza Moslem; Zahra Meshkat; Ameneh Timar; Seyed-Amir Tabatabaeizadeh; Hamideh Ghazizadeh; Roshanak Ghaffarian Zirak; Meysam Moghbeli; Nadia Boroumand; Naghme jaberi; Mohammad Mohammadzadeh; Gordon A. Ferns; Hamid Reza Bahrami; Majid Ghayour-mobarhan. "The Association between Red Blood Cell Distribution Width and Metabolic Syndrome in Adolescent Girls". , 11, 2, 1401, 17416-17427. doi: 10.22038/ijp.2023.60826.4692
Fazeli, Mostafa, Moslem, Ali Reza, Meshkat, Zahra, Timar, Ameneh, Tabatabaeizadeh, Seyed-Amir, Ghazizadeh, Hamideh, Ghaffarian Zirak, Roshanak, Moghbeli, Meysam, Boroumand, Nadia, jaberi, Naghme, Mohammadzadeh, Mohammad, Ferns, Gordon A., Bahrami, Hamid Reza, Ghayour-mobarhan, Majid. (1401). 'The Association between Red Blood Cell Distribution Width and Metabolic Syndrome in Adolescent Girls', , 11(2), pp. 17416-17427. doi: 10.22038/ijp.2023.60826.4692
Fazeli, Mostafa, Moslem, Ali Reza, Meshkat, Zahra, Timar, Ameneh, Tabatabaeizadeh, Seyed-Amir, Ghazizadeh, Hamideh, Ghaffarian Zirak, Roshanak, Moghbeli, Meysam, Boroumand, Nadia, jaberi, Naghme, Mohammadzadeh, Mohammad, Ferns, Gordon A., Bahrami, Hamid Reza, Ghayour-mobarhan, Majid. The Association between Red Blood Cell Distribution Width and Metabolic Syndrome in Adolescent Girls. , 1401; 11(2): 17416-17427. doi: 10.22038/ijp.2023.60826.4692

The Association between Red Blood Cell Distribution Width and Metabolic Syndrome in Adolescent Girls

Journal of Pediatric Perspectives
مقاله 9، دوره 11، شماره 2، اردیبهشت 2023، صفحه 17416-17427    اصل مقاله (245.75 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2023.60826.4692
نویسندگان
Mostafa Fazeli1؛ Ali Reza Moslem2؛ Zahra Meshkat3؛ Ameneh Timar4؛ Seyed-Amir Tabatabaeizadeh5؛ Hamideh Ghazizadeh6؛ Roshanak Ghaffarian Zirak7؛ Meysam Moghbeli6؛ Nadia Boroumand8؛ Naghme jaberi8؛ Mohammad Mohammadzadeh9؛ Gordon A. Ferns10؛ Hamid Reza Bahrami4؛ Majid Ghayour-mobarhan* 11
1Department of medical genetic and molecular medicine, faculty of medicine, mashhad university of medical sciences
2Department of Anesthesiology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran
5Clinical Nutrition Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
7Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
9Department of Physiology & Pharmacology, Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
10Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK
11Director of Department of New Sciences and Technology, Founding Member of Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences,Mashhad, Iran.
چکیده
Background: Metabolic syndrome (MetS) is characterized by metabolic and anthropometric abnormalities which are associated with an increased risk of cardiovascular disease (CVD). Red blood cell distribution width is a candidate biomarker for CVD.
Method: Nine hundred and eighty-eight girls who were between 12 to 18 years old were enrolled. Anthropometric parameters and blood pressure were measured, together with biochemical and hematological variables, using routine measures. International diabetes federation (IDF) criteria were used for the diagnosis of MetS.
Result: Some of the demographic parameters such as weight, neck circumference (NC), waist circumference (WC) and hip circumference (HP) were significantly different between the groups with and without MetS, as may be expected. Significantly higher values for red blood cell distribution width (RDW) were observed only in subjects with waist circumference (P= 0.017) and fasting blood glucose levels (P= 0.038). RDW measures were directly associated with MetS status (r=0.076 (P =0.043)), WC (r=0.097 (P =0.016)), and fasting blood glucose (FBG) (r= -0.085 (P =0.037)). It was found that the RDW had specificity and sensitivity for MetS-based IDF criteria 48.01 and 77.78, respectively. RDW related cure area (95% CI) for MetS was reported to be 0.588 (0.380- 0.796).
Conclusion: We found that an elevated RDW was associated with the presence of MetS and with some its components; but ROC analysis revealed that a weak specificity in spite of good sensitivity of RDW for MetS, along with a low AUC may make it unusable for the diagnostic prediction of MetS in this population.
کلیدواژه‌ها
red blood cell distribution width؛ metabolic syndrome؛ cardiovascular disease؛ biomarker
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