Hangover headache and its behavioral changes in rats | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 9، دوره 26، شماره 3، خرداد 2023، صفحه 326-334 اصل مقاله (806.25 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2023.66724.14644 | ||
| نویسندگان | ||
| Lu Shiguang1؛ Zhang Ying1؛ Yang Yuejun1؛ Zhang Yafang1؛ Qin Guangcheng2؛ Fu Qingqing2؛ Shi Yingying1؛ Zhang Fan1؛ Wang Zhe1؛ Chen Yanhe1؛ Liu Yuancai* 1؛ chen Lixue* 2 | ||
| 1Hubei Provincial Key Lab for Quality and Safety of Traditional Chinese Medicine Health Food, Hubei, China | ||
| 2Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China | ||
| چکیده | ||
| Objective(s): The present study aims to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks. Materials and Methods: Chronic migraine (CM) model rats were divided into 3 groups, and intragastrically administered alcoholic drinks (sample A, B, or C) to simulate hangover headache attacks. The withdrawal threshold for the hind paw/face and the thermal latency of hind paw withdrawal were detected after 24 hr. Serum was collected from the periorbital venous plexus of rats in each group, and enzymatic immunoassays were used to determine the serum levels of calcitonin gene-related peptide (CGRP), substance P (SP), and nitric oxide (NO). Results: Compared with the control group, the mechanical hind paw pain threshold was significantly lower in rats administered Samples A and B after 24 hr; however, no significant difference was observed across groups for the thermal pain threshold. The mechanical threshold for periorbital pain was only significantly reduced in rats administered Sample A. Immunoassays further indicated that serum levels of SP in the group administered Sample A were significantly higher than those in the control group; the serum levels of NO and CGRP were significantly higher in the group of rats receiving Sample B. Conclusion: We successfully developed an effective and safe rat model for investigating alcohol drink induced hangover headaches. This model could be used to investigate the mechanisms associated with hangover headaches for the development of novel and promising candidates for the future treatment or prophylaxis of hangover headaches. | ||
| کلیدواژهها | ||
| Alcohol؛ Animal؛ Behavior؛ Central nervous system - sensitization؛ Disease models؛ Hangover؛ Headche | ||
| مراجع | ||
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1. Courtney KE, Worley M, Castro N, Tapert SF. The effects of alcohol hangover on future drinking behavior and development of alcohol problems. Addict Behav 2018;78:209-215. 2. Merlo A, Adams S, Benson S, Devenney L, Gunn C, Iversen J, Verster JC. Proceeding of the 9th Alcohol Hangover Research Group Meeting. Curr. Drug Abu Rev 2017;10:68–75. 3. Royle S, Owen L, Roberts D, Marrow L, Pain catastrophising predicts alcohol hangover severity and symptoms. J Clin Med 2020;9:11-15. 4. Eriksson CJP, Metsälä M, Möykkynen T, Mäkisalo H, Kärkkäinen O, Palmén M, Salminen JE, Kauhanen J. L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety. Alcohol Alcohol 2020;55:660-666. 5. Onderwater GLJ, Vanoostrhout WPJ, Schoonman GG, Ferrari MD,Terwindt GM. Alcoholic beverages as trigger factor and the effect on alcohol consumption behavior in patients with migraine.Eur J Neuro 2019;26:588-595. 6. Panconesi A. Alcohol and migraine: trigger factor, con-sumption, mechanisms. A review. J Headache Pain 2008;9:19–27. 7. Panconesi A. Alcohol-induced headaches: evidence for a central mechanism? J Neurosci Rural Pract 2016;7:269–275. 8. Panconesi A, Franchini M, Bartolozzi ML, Mugnai S, Guidi L, Alcohol Drinks as triggers in primary headaches. Pain Med 2013;14:1254-1259. 9. Royle S, Owen L, Roberts D, Marrow L. Pain catastrophising predicts alcohol hangover severity and symptoms. J Clin Med 2020:9:280. 10. Oshinsky ML, Gomonchareonsiri S. Episodic dural stimulation in awake rats: A model for recurrent headache. Headache 2007;47:1026–1036. 11. Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF. American migraine prevalence prevention advisory group. Cutaneous allodynia in the migraine population. Ann Neurol 2008;63:148–158. 12. Hawkins JL, Moore NJ, Miley D, Durham PL. Secondary traumatic stress increases expression of proteins implicated in peripheral and central sensitization of trigeminal neurons. Brain Res 2018;1687:162-172. 13. Tajti J, Szok D, Majláth Z, Tuka B, Csáti A, László, Vécsei L.Migraine and neuropeptides. Neuropeptides 2015; 52:19-30. 14. Iyengar S, Ossipov MH, Johnson KW.The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine. Pain 2017;158:543-559. 15. Zhou X, Liang J, Wang J, Fei ZY, Qin GC, Zhang DK, Zhou JY, Chen LX. Upregulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine. J Neurochem 2020;155:370-389. 16. Pradhan AA, Bertels Z, Akerman S.Targeted Nitric Oxide Synthase Inhibitors for Migraine. Neurotherapeutics 2018;15:391-401. 17. Taheri P, Mohammadi F, Nazeri M, Zarei MR, Chamani G, Esfahlani MA, Taheri F, Shabani M. Nitric oxide role in anxiety-like behavior, memory and cognitive impairments in animal model of chronic migraine. Heliyon. 2020;6:e05654. 18. Qin GC, Fan XP, Chen LX, Shen CB, Gui B, Tan G, Zhou JY. Preventive effects of AdR-siPTEN through the regulation of NMDA receptor NR2B subunit in trigeminal ganglia of migraine rats. Neurol Res.2012;34:998-1006. 19. Wieseler J, Ellis A, Sprunger D, Brown K, McFadden A, Mahoney J, Rezvani N. A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats. J Neurosci Methods 2010;185:236-245. 20. Qin GC, Xie JM, Chen LX, Wu BX, Gui B, Zhou JY. PTEN inhibition preserves trigeminal nucleus caudalis neuron activation through tyrosine phosphorylation of the NR2B subunit at Tyr1472 of the NMDA receptor in a rat model of recurrent migraine. Neurol Res2016;38:320-226. 21. Zhang Y, Standifer KM.Exacerbated Headache-Related Pain in the Single Prolonged Stress Preclinical Model of Post-traumatic Stress Disorder. Cell Mol Neurobiol 2021;41:1009-1018. 22. Zhou ZK, Xue LJ, Ye Q, Liu S, Liu X, Wu WH, Wan Q. The effect of expression of connexin 40 in trigeminal ganglion and pain threshold following electrical stimulation on superlor sagittal sinus. Chin J Pain Med 2011;17: 558-562. 23. Wang YL, Su YS, He W, Jing XH. Electroacupuncture relieved visceral and referred hindpaw hypersensitivity in colitis rats by inhibiting tyrosine hydroxylase expression in the sixth lumbar dorsal root ganglia. Neuropeptides 2019;77:101957. 24. Zhang MY, Zheng L, Deng H. Establishment of a model in mice for assessing Luzhuo flavor liquor’s degree of drunkenness.Mod Prev Med 2010,27: 3623-3625. 25. Zheng HX, Zhang L. Effects of esters and higher alcohols in beer on the behavior of mice. Jiling agriculture 2011;9: 85. 26. Gu YQ. Expression of TLR4 and its effects on release of inflammatory mediators in midbrain in MPTP mouse models of Parkinson’ disease, 2014. Southern Medical University. 27. Simonet C, Galmes MA, Lambert C, Rees RN, Haque T, Bestwick JP, Lees AJ, Schrag A, Noyce AJ. Slow Motion Analysis of Repetitive Tapping (SMART) Test: Measuring Bradykinesia in Recently Diagnosed Parkinson’s Disease and Idiopathic Anosmia. J Parkinsons Dis 2021;11:1901-1915. 28. Hu JH, LI Y, Cao XW. Influence on nerve function of kuming mice induced by alcohols. Pract Prev Med 2016:818-820. 29. Russo A, Coppola G, Pierelli F, Parisi V, Silvestro M, Tessitore A, Tedeschi G. Pain perception and migraine. Front Neurol 2018; 9:576. 30. Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol 2010;68:81-91. 31. Wober C, Brannath W, Schmidt K. Prospective analysis of factors related to migraine attacks: The PAMINA study. Cephalalgia 2007;27:304-314. 32. Dasari VR, Clark AJ, Boorigie ME, Gerson T, Connelly MA, Bickel JL. The influence of lifestyle factors on the burden of pediatric migraine. J Pediatr Nurs 2021;57:79-83. 33. Hindiyeh NA, Zhang N, Farrar M, Banerjee P, Lombard L, Aurora SK.The role of diet and nutrition in migraine triggers and treatment: A systematic literature review. Headache 2020;60:1300-1316. 34. Alabwah Y, Ji Y, Seminowicz DA, Quiton RL,Masri R. Alcohol-triggered signs of migraine: An animal model. Somatosensory Mot Res 2016;33:35-41. 35. Christina RM, Rebecca JS, Jan BH. Silberstein SD, Oshinsky ML. Acetate causes alcohol hangover headache in rats, PLoS One 2010;5:e15963.1-9. 36. Long T, He W, Pan Q, Zhang SS, Zhang YX, Liu CY, Liu Q, Qin GC, Chen LX, Zhou JY. Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation. J Neuroinflammation 2018; 245: 1-11. 37. Iyengar S, Ossipov MH, Johnson KW.The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine. Pain 2017;158:543-559. 38. Vatsalya V, Stangl BL, Schmidt VY, Ramchandani VA. Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications. Addict Biol 2018;23:493-502. 39. Palmer E, Tyacke R, Sastre M, Lingford-Hughes A, Nutt D, Ward RJ. Alcohol hangover: Underlying biochemical, inflammatory and neurochemical mechanisms. Alcohol Alcohol 2019 ;54:196-203. 40. Mackus M, Loo AJ, Garssen J, Kraneveld A, Scholey A, Verster JC. The role of alcohol metabolism in the pathology of alcohol hangover. J Clin Med 2020 9: 3421. | ||
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