سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Altan, Mehmet, Yaman, Muhittin, Kervancioglu, Gulnaz, Kilic, Aysu, Kervancioglu Demirci, Elif, Bozdogan Polat, Sila Hidayet, Karadeniz, Zeliha, Guner, Ibrahim, Yelmen, Nermin, Sahin, Gulderen. (1401). Aortic Ischemia-Reperfusion Injury and Potency of Fluoxetine. , 26(3), 301-307. doi: 10.22038/ijbms.2023.65974.14508
Mehmet Altan; Muhittin Onur Yaman; Gulnaz Kervancioglu; Aysu Kilic; Elif Kervancioglu Demirci; Sila Hidayet Bozdogan Polat; Zeliha Karadeniz; Ibrahim Guner; Nermin Yelmen; Gulderen Sahin. "Aortic Ischemia-Reperfusion Injury and Potency of Fluoxetine". , 26, 3, 1401, 301-307. doi: 10.22038/ijbms.2023.65974.14508
Altan, Mehmet, Yaman, Muhittin, Kervancioglu, Gulnaz, Kilic, Aysu, Kervancioglu Demirci, Elif, Bozdogan Polat, Sila Hidayet, Karadeniz, Zeliha, Guner, Ibrahim, Yelmen, Nermin, Sahin, Gulderen. (1401). 'Aortic Ischemia-Reperfusion Injury and Potency of Fluoxetine', , 26(3), pp. 301-307. doi: 10.22038/ijbms.2023.65974.14508
Altan, Mehmet, Yaman, Muhittin, Kervancioglu, Gulnaz, Kilic, Aysu, Kervancioglu Demirci, Elif, Bozdogan Polat, Sila Hidayet, Karadeniz, Zeliha, Guner, Ibrahim, Yelmen, Nermin, Sahin, Gulderen. Aortic Ischemia-Reperfusion Injury and Potency of Fluoxetine. , 1401; 26(3): 301-307. doi: 10.22038/ijbms.2023.65974.14508

Aortic Ischemia-Reperfusion Injury and Potency of Fluoxetine

Iranian Journal of Basic Medical Sciences
مقاله 6، دوره 26، شماره 3، خرداد 2023، صفحه 301-307    اصل مقاله (497.06 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2023.65974.14508
نویسندگان
Mehmet Altan1؛ Muhittin Onur Yaman2؛ Gulnaz Kervancioglu3؛ Aysu Kilic4؛ Elif Kervancioglu Demirci5؛ Sila Hidayet Bozdogan Polat1؛ Zeliha Karadeniz6؛ Ibrahim Guner7؛ Nermin Yelmen1؛ Gulderen Sahin* 8
1Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Physiology, Istanbul, Turkey
2Vocational Sch. of Health Sciences, Istanbul University-Cerrahpaşa, Istanbul, Turkey
3Istanbul Aydın University, Medical Faculty, Department of Histology & Embryology, Istanbul, Turkey
4Department of Physiology, Medical Faculty, Bezmialem University, Istanbul, Turkey
5Istanbul University, Istanbul Faculty of Medicine, Department of Histology & Embryology, Istanbul, Turkey
6Istanbul Aydın University, Medical Faculty, Department of Obstetrics & Gynecology, Istanbul, Turkey
7Tekirdağ Namık Kemal University, Medical Faculty, Department of Physiology, Tekirdağ, Turkey
8Istanbul Aydın University, Medical Faculty, Department of Physiology, Istanbul, Turkey
چکیده
OBJECTIVE(S): Due to cross-clamping of the aorta during aortic aneurysm surgeries, ischemia-reperfusion (IR) develops, and it may cause damage to aorta itself or even to remote organs by oxidative stress or inflammation. Fluoxetine (FLX) which might be used in the preoperative period for its tranquilizing effect also has antioxidant effects in short-term use. The purpose of our study is to examine whether FLX protects aorta tissue, against the damage caused by IR.

METHODS: 3 groups of Wistar rats formed randomly. 1) Control group (sham-operated), 2) IR group (60 min. ischemia+120 min. perfusion), 3) FLX+IR group (FLX dose was 20 mg/kg for 3 days i.p. before IR). At the end of each procedure, aorta samples were collected, and oxidant-antioxidant, anti-inflammatory, and anti-apoptotic status of the aorta were evaluated. Histological examinations of the samples were provided.

RESULTS: Levels of LOOH, MDA, ROS, TOS, MPO, TNFα, IL-1β, IL-6, NF-kB, MMP-9, caspase-9, 8-OHdG, NO, and HA were found to be significantly increased in the IR group compared to control (p<0.05) and the SOD, GSH, TAS, and IL-10 levels were significantly lower (p<0.05). FLX significantly decreased LOOH, MDA, ROS, TOS, MPO, TNFα, IL-1β, IL-6, NF-kB, MMP-9, caspase-9, 8-OHdG, NO, and HA levels in the FLX+IR group compared to IR group (p<0.05) and increased IL-10, SOD, GSH, and TAS (p<0.05). FLX administration prevented the deterioration of aortic tissue damage.

CONCLUSION: Our study is the first study that demonstrates FLX mediated suppression of IR injury in the infrarenal abdominal aorta by antioxidant, anti-inflammatory, and anti-apoptotic properties.
کلیدواژه‌ها
Fluoxetine؛ aorta؛ reperfusion injury؛ oxidative stress؛ inflammation؛ apoptosis؛ rat
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