Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 11، دوره 17، شماره 1، فروردین 2014، صفحه 69-72 اصل مقاله (715.12 K) | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2014.2159 | ||
| نویسندگان | ||
| Mohammad Karami* 1؛ Faezeh Karimian Nokabadi1؛ Mohammad Ali Ebrahimzadeh2؛ Farshad Naghshvar3 | ||
| 1Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 2Department of Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 3Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran | ||
| چکیده | ||
| Objective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used. Results : Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P <0.05). Not statistically significant was observed in effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P Conclusion: F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice. | ||
| کلیدواژهها | ||
| Feijoa sellowiana؛ Kidney glutathione؛ MDMA؛ Nephrotoxicity | ||
| مراجع | ||
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