سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Shirazi, Mahboobeh, Feizabad, Elham, Bahmanpour, Ghazaleh, Ghaemi, Marjan, Takaloo, Fatemeh, Shirazi, Mahmoud, Omidi Farzin, Alireza, Heidarpour, Azadeh. (1401). Short Neonatal Outcomes after Intrauterine Transfusion in Fetal Anemia, the Experience from a Referral Academic Center. , 13(4), 28-33. doi: 10.22038/ijn.2022.63924.2225
Mahboobeh Shirazi; Elham Feizabad; Ghazaleh Bahmanpour; Marjan Ghaemi; Fatemeh Takaloo; Mahmoud Shirazi; Alireza Omidi Farzin; Azadeh Heidarpour. "Short Neonatal Outcomes after Intrauterine Transfusion in Fetal Anemia, the Experience from a Referral Academic Center". , 13, 4, 1401, 28-33. doi: 10.22038/ijn.2022.63924.2225
Shirazi, Mahboobeh, Feizabad, Elham, Bahmanpour, Ghazaleh, Ghaemi, Marjan, Takaloo, Fatemeh, Shirazi, Mahmoud, Omidi Farzin, Alireza, Heidarpour, Azadeh. (1401). 'Short Neonatal Outcomes after Intrauterine Transfusion in Fetal Anemia, the Experience from a Referral Academic Center', , 13(4), pp. 28-33. doi: 10.22038/ijn.2022.63924.2225
Shirazi, Mahboobeh, Feizabad, Elham, Bahmanpour, Ghazaleh, Ghaemi, Marjan, Takaloo, Fatemeh, Shirazi, Mahmoud, Omidi Farzin, Alireza, Heidarpour, Azadeh. Short Neonatal Outcomes after Intrauterine Transfusion in Fetal Anemia, the Experience from a Referral Academic Center. , 1401; 13(4): 28-33. doi: 10.22038/ijn.2022.63924.2225

Short Neonatal Outcomes after Intrauterine Transfusion in Fetal Anemia, the Experience from a Referral Academic Center

Iranian Journal of Neonatology
مقاله 6، دوره 13، شماره 4، دی 2022، صفحه 28-33    اصل مقاله (528.71 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijn.2022.63924.2225
نویسندگان
Mahboobeh Shirazi1؛ Elham Feizabad2؛ Ghazaleh Bahmanpour1؛ Marjan Ghaemi3؛ Fatemeh Takaloo4؛ Mahmoud Shirazi5؛ Alireza Omidi Farzin6؛ Azadeh Heidarpour* 1
1Yas Hospital Complex, Maternal Fetal and Neonatal Research Center,Tehran University of Medical Sciences, Tehran, Iran
2Community medicine specialist, Yas Hospital Complex Department of obstetrics and gynecology, Tehran University of Medical Sciences, Tehran, Iran
3Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4Hamedan University of Medical Sciences, Hamedan, Iran
5Department of Psychology, Faculty of educational and psychology, University of Sistan and Baluchestan, Zahedan, Iran
6Shahid Modarres Hospital, Department of Cardiovascular Surgery,Shahid Beheshti University of Medical Sciences, Tehran,Iran
چکیده
Background: Rhesus D-antibodies and maternal red blood cell alloimmunizations are the major causes of fetal anemia, which can cause hydrops and perinatal death if not treated through intrauterine intravascular blood transfusion (IUT). This paper sought to report the short-term neonatal outcomes after IUT in a referral academic center.
Methods: The population of this retrospective cohort study comprised all pregnancies that underwent IUT between March 2014 and March 2019. The maternal obstetrics characteristics as well as blood group, antibody screen, and titers were reported. Indeed, the fetal and neonatal outcomes and complications were described either.
Results: A total of 141 IUTs were performed in 58 women. Of all, 15 fetuses were hydropic at the first transfusion. The mean±SD (standard deviation) of gestational age and hemoglobin at the first transfusion was 27.06±4.25 weeks and 6.62±2.91 g/dL, respectively. The range of transfusions was 1.8 per woman and the mean±SD amount of blood transfusion in IUT was 84.03±48.79 cc. 7/58 (12%) intrauterine and 6/58 (10%) neonatal death were reported, of which, four cases were hydropic and the others suffered from severe anemia. The mean±SD of gestation age at delivery was 33.6 ± 3.33 weeks. A significant difference was observed between mean fetal hemoglobin levels before and after performing the IUT procedure (p< 0.01). Also, middle cerebral artery (MCA) Doppler assessments showed anemia severity decreased following IUT
Conclusion: It seems Intrauterine transfusion is a lifesaving procedure that can boost perinatal survival in fetuses with anemia.
 
 
کلیدواژه‌ها
Anemia؛ Hydrops fetalis؛ Intrauterine blood transfusion
مراجع
  1. Abbasi, N., Johnson, J.-A. and Ryan, G. (2017). Fetal anemia. Ultrasound Obstet Gynecol, 50: 145-153.
  2. Pasman SA, Claes L, Lewi L, Van Schoubroeck D, Debeer A, Emonds M, Geuten E, De Catte L, Devlieger R. Intrauterine transfusion for fetal anemia due to red blood cell alloimmunization: 14 years experience in Leuven. Facts, Views & Vision in ObGyn. 2015;7(2):129.
  3. Rosenbloom JI, Bruno AM, Conner SN, Tuuli MG, Simon LE, Macones GA, Cahill AG. Fetal thrombocytopenia in pregnancies complicated by fetal anemia due to red-cell alloimmunization: a cohort study and meta-analysis. J Perinatol. 2019 Jul;39(7):920-926.
  4. Abbasi N, Johnson JA, Rayan G. Fetal anemia. Ultrasound Obstet Gynecol 2017; 50: 145–153
  5. Zwiers C, Kamp I, Oepkes D, Lopriore E. Intrauterine transfusion and non-invasive treatment options for hemolytic disease of the fetus and newborn – review on current management and outcome. Expert Review of Hematology, 10:4,337-344.
  6. Liley AW. Intrauterine transfusion of foetus in haemolyticdisease. Br Med J 1963; 2:1107–9. doi: 10.1136/bmj.2.5365.1107.
  7. Sarah Horvath, Vinita Goyal, Sarah Traxler, Sarah Prager, Society of Family Planning committee consensus on Rh testing in early pregnancy Contraception, 2022;114,:1-5
  8. Lindenburg I, van Kamp I, Oepkes D. Intrauterine blood transfusion: current indications and associated risks. Fetal Diagnosis and Therapy 2014;36:263–271.
  9. Urutherakumar V, Welsh A, Henry A. Short-term outcomes following intrauterine transfusions for fetal anaemia: a retrospective cohort study. Aust N Z J Obstet Gynaecol. 2020
  10. Pasman SA, Claes L, Lewi L, Van Schoubroeck D, Debeer A, Emonds M, Geuten E, De Catte L, Devlieger R. Intrauterine transfusion for fetal anemia due to red blood cell alloimmunization: 14 years experience in Leuven. Facts, Views & Vision in ObGyn. 2015;7(2):129.
  11. Deka D, Dadhwal V, Sharma AK, Shende U, Agarwal S, Agarwal R, Vanamail P. Perinatal survival and procedure-related complications after intrauterine transfusion for red cell alloimmunization. Archives of Gynecology and Obstetrics. 2016;293(5):967-73.
  12. De Boer IP, Zeestraten EC, Lopriore E, Van Kamp IL, Kanhai HH, Walther FJ. Pediatric outcome in Rhesus hemolytic disease treated with and without intrauterine transfusion. American Journal of Obstetrics And Gynecology. 2008;;198(1):54.
  13. Rahimi-Sharbaf F, Niromanesh S, Talebzadeh Z, Kaveh M, Nayary F. Rh alloimmunization and term delivery. Arch Iran Med. 2007
  14. Tiblad E, Kublickas M, Ajne G, Ek S, Karlsson
    A, Wikman A, Westgren M. Procedure-related complications and perinatal outcome after intrauterine transfusions in red cell alloim-munization in Stockholm. Fetal Diagnosis and Therapy. 2011;30(4):266-73.
آمار
تعداد مشاهده مقاله: 347
تعداد دریافت فایل اصل مقاله: 474