Antiphospholipid antibodies and COVID-19 mortality and thrombotic events; A systematic review and meta-analysis | ||
| Reviews in Clinical Medicine | ||
| دوره 9، شماره 4، اسفند 2022، صفحه 186-195 اصل مقاله (709.58 K) | ||
| نوع مقاله: Meta- analysis | ||
| شناسه دیجیتال (DOI): 10.22038/rcm.2022.67632.1413 | ||
| نویسندگان | ||
| Reza Jafarzadeh Esfehani1؛ Mohammad ali khalilifar2؛ Hadi Esmaeili Gouvarchinghaleh3؛ Gholam Hossein Alishiri4؛ Alireza Shahriary* 5 | ||
| 1Students Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran. Blood born Disease research center, Academic Center for Education, Culture, and Research (ACECR)-Khorasan Razavi, Mashhad, Iran | ||
| 2Blood born Disease research center, Academic Center for Education, Culture, and Research (ACECR)-Khorasan Razavi, Mashhad, Iran. | ||
| 3Applied Virology Research Centre, Baqiyatallah University Medical Sciences, Tehran, Iran. | ||
| 4Chemical Injuries Research Center, Systems Biology and poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. | ||
| 5Chemical Injuries Research Center, Systems Biology and poisoning institute, Baqiyatall University of Medical Sciences, Tehran, Iran. | ||
| چکیده | ||
| Introduction:Among various proposed pathologic mechanisms during the coronavirus disease 2019 (COVID-19) pandemic, overproduction of autoantibodies is not widely studied. Antiphospholipid antibodies (aPLs) are target proteins that have affinity toward charged phospholipids. APLs are thought to have pro-thrombotic potentials that increase during thromboembolism. The present systematic review and meta-analysis aimed to evaluate the relationship between serum aPLs level and COVID-19 mortality, severity, and thrombotic events. Methods: This systematic review and meta-analysis was conducted on all open access published articles in Medline, Scopus and Google Scholar. Studies evaluating individuals over the age of 18 years who were diagnosed with COVID-19 and had positive aPLs; and provided data on mortality or thrombotic events were included. Results: Of the initially identified 512 articles, 22 studies (overall 1462 patients) were finally included in the analysis. The prevalence of positive aPLs was 48.1%. Among the 372 patients with positive aPLs, 156 patients (41.9%) had severe COVID-19 that indicated a significant relationship between COVID-19 severity and aPLs positivity (p<0.05). The prevalence of thrombotic events in aPLs positive patients was 26.3% that indicated a significant relationship between aPLs positivity and the development of thrombotic events (p=0.03). APLs positivity was related to anytime mortality in COVID-19 patients (p=0.01). Conclusion: The present review demonstrated that aPLs are linked to COVID-19 severity and thrombotic events but not short-term mortality. Further studies with longer follow up periods are warranted. | ||
| کلیدواژهها | ||
| COVID-19؛ mortality؛ thrombosis؛ antiphospholipid antibodies | ||
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