Demircigil, Nursena, Gul, Mehmet, Gokturk, Nurcan, Kayhan Kustepe, Elif, Gozukara Bag, Harika, Erdemli, Mehmet. (1401). Thymoquinone played a protective role against tartrazine-induced hepatotoxicity. , 26(1), 99-106. doi: 10.22038/ijbms.2022.67341.14763
Nursena Demircigil; Mehmet Gul; Nurcan Gokturk; Elif Kayhan Kustepe; Harika Gozukara Bag; Mehmet Erman Erdemli. "Thymoquinone played a protective role against tartrazine-induced hepatotoxicity". , 26, 1, 1401, 99-106. doi: 10.22038/ijbms.2022.67341.14763
Demircigil, Nursena, Gul, Mehmet, Gokturk, Nurcan, Kayhan Kustepe, Elif, Gozukara Bag, Harika, Erdemli, Mehmet. (1401). 'Thymoquinone played a protective role against tartrazine-induced hepatotoxicity', , 26(1), pp. 99-106. doi: 10.22038/ijbms.2022.67341.14763
Demircigil, Nursena, Gul, Mehmet, Gokturk, Nurcan, Kayhan Kustepe, Elif, Gozukara Bag, Harika, Erdemli, Mehmet. Thymoquinone played a protective role against tartrazine-induced hepatotoxicity. , 1401; 26(1): 99-106. doi: 10.22038/ijbms.2022.67341.14763

Thymoquinone played a protective role against tartrazine-induced hepatotoxicity

Iranian Journal of Basic Medical Sciences
مقاله 13، دوره 26، شماره 1، فروردین 2023، صفحه 99-106    اصل مقاله (1003.88 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/ijbms.2022.67341.14763
نویسندگان
Nursena Demircigil1؛ Mehmet Gul2؛ Nurcan Gokturk1؛ Elif Kayhan Kustepe3؛ Harika Gozukara Bag4؛ Mehmet Erman Erdemli* 1
1Department of Medical Biochemistry, Medical Faculty, İnönü University, Malatya, Turkey
2Department of Histology and Embryology, Medical Faculty, İnönü University, Malatya, Turkey
3Department of Histology and Embryology, Medical Faculty, Turgut Ozal University, Malatya, Turkey
4Department of Biostatistics, Medical Faculty, Inonu University, Malatya, Turkey
چکیده
Objective(s): The current study, the first of its kind in the literature, aimed to observe the toxic effects of Tartrazine, a commonly used dyestuff in industries and foods, on the liver, and investigate whether this toxicity could be eliminated with thymoquinone coadministration. 
Materials and Methods: 32 male Wistar albino rats were procured from İnönü University Experimental Animals Breeding and Research Center. The rats were randomly assigned to 4 equal groups: Control group, Thymoquinone group, Tartrazine group, and Thymoquinone + Tartrazine group. Rat liver tissue and blood samples were obtained and biochemical and histopathological examinations were conducted on the samples.
Results: Tartrazine administration increased the oxidant (malondialdehyde and superoxide dismutase) and oxidative stress index parameters (total oxidant status) in the liver tissue and decreased the antioxidant parameters (glutathione, glutathione peroxidase, catalase, and total antioxidant status) leading to histopathological problems (hematoxylin-eosin staining and Caspase-3 immunoreactivity) and inflammation (tumor necrosis factor-α and interleukin-6) in the serum samples. Thymoquinone, on the other hand, improved antioxidant and anti-inflammatory effects. 
Conclusion: At this time and dose, thymoquinone has a protective effect against tartrazine hepatotoxicity. Thymoquinone can be used as a protective agent against tartrazine toxicity. 
کلیدواژه‌ها
Hepatotoxicity؛ Inflammation؛ Oxidative stress؛ Rat؛ Tartrazine؛ Thymoquinone
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