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Safavinia, Ashkan, Dehestani, Sina, Salmasi, Zahra, Kalalinia, Fatemeh, Etemad, Leila, Hashemi, Maryam. (1402). Recent advances in nanocarriers containing Bromelain: In vitro and in vivo studies. , 10(3), 163-170. doi: 10.22038/nmj.2022.67975.1724
Ashkan Safavinia; Sina Dehestani; Zahra Salmasi; Fatemeh Kalalinia; Leila Etemad; Maryam Hashemi. "Recent advances in nanocarriers containing Bromelain: In vitro and in vivo studies". , 10, 3, 1402, 163-170. doi: 10.22038/nmj.2022.67975.1724
Safavinia, Ashkan, Dehestani, Sina, Salmasi, Zahra, Kalalinia, Fatemeh, Etemad, Leila, Hashemi, Maryam. (1402). 'Recent advances in nanocarriers containing Bromelain: In vitro and in vivo studies', , 10(3), pp. 163-170. doi: 10.22038/nmj.2022.67975.1724
Safavinia, Ashkan, Dehestani, Sina, Salmasi, Zahra, Kalalinia, Fatemeh, Etemad, Leila, Hashemi, Maryam. Recent advances in nanocarriers containing Bromelain: In vitro and in vivo studies. , 1402; 10(3): 163-170. doi: 10.22038/nmj.2022.67975.1724

Recent advances in nanocarriers containing Bromelain: In vitro and in vivo studies

Nanomedicine Journal
مقاله 1، دوره 10، شماره 3، مهر 2023، صفحه 163-170    اصل مقاله (438.79 K)
نوع مقاله: Review Paper
شناسه دیجیتال (DOI): 10.22038/nmj.2022.67975.1724
نویسندگان
Ashkan Safavinia1؛ Sina Dehestani2؛ Zahra Salmasi3، 4؛ Fatemeh Kalalinia5، 6؛ Leila Etemad5، 7؛ Maryam Hashemi* 4، 6
1School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
3Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
5Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
6Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
7Department of Drug and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Medicinal products of plant origin have long been considered the most affordable and accessible sources to treat different health problems. Bromelain (Br) is a mixture of enzymes derived from pineapple (Ananas comosus L.) with a wide field of applications including medicine, health, food, and cosmetics. Br has various therapeutic effects, such as antimicrobial, antioxidant, anticancer, wound healing, burn treatment, pain relief, anti-inflammatory, inhibition of platelet aggregation, and fibrinolytic activity. On the other hand, most proteins are susceptible to denaturation and structural changes that may reduce their activities. Encapsulation of drug molecules into nanoparticles (NPs) could increase their stability, bioavailability, and overcome other challenges in drug delivery and therapy. This review aimed to highlight various Br nano-formulations approaches, toward the improvement of Br therapeutic efficiency. 
کلیدواژه‌ها
Bromelain؛ Nanoparticles؛ Pineapple؛ Stability؛ Therapeutic application
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