سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

zardast, mahmoud, Zardast, Amirhosein, Namakin., kookab, Sharifzadeh, Gholam Reza, Khodaparast, Maryam. (1401). A Comparison of Serum Magnesium and Blood Sugar Levels between Obese and Normal-Weight Adolescents. , 10(12), 17077-17084. doi: 10.22038/ijp.2022.67776.5058
mahmoud zardast; Amirhosein Zardast; kookab Namakin.; Gholam Reza Sharifzadeh; Maryam Khodaparast. "A Comparison of Serum Magnesium and Blood Sugar Levels between Obese and Normal-Weight Adolescents". , 10, 12, 1401, 17077-17084. doi: 10.22038/ijp.2022.67776.5058
zardast, mahmoud, Zardast, Amirhosein, Namakin., kookab, Sharifzadeh, Gholam Reza, Khodaparast, Maryam. (1401). 'A Comparison of Serum Magnesium and Blood Sugar Levels between Obese and Normal-Weight Adolescents', , 10(12), pp. 17077-17084. doi: 10.22038/ijp.2022.67776.5058
zardast, mahmoud, Zardast, Amirhosein, Namakin., kookab, Sharifzadeh, Gholam Reza, Khodaparast, Maryam. A Comparison of Serum Magnesium and Blood Sugar Levels between Obese and Normal-Weight Adolescents. , 1401; 10(12): 17077-17084. doi: 10.22038/ijp.2022.67776.5058

A Comparison of Serum Magnesium and Blood Sugar Levels between Obese and Normal-Weight Adolescents

Journal of Pediatric Perspectives
مقاله 3، دوره 10، شماره 12، اسفند 2022، صفحه 17077-17084    اصل مقاله (185.9 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2022.67776.5058
نویسندگان
mahmoud zardast1؛ Amirhosein Zardast* 2؛ kookab Namakin.3؛ Gholam Reza Sharifzadeh4؛ Maryam Khodaparast5
1associate professor of cardiovascular research center of birjand university of medical sciences
2Student research committee of Mashhad university of medical sciences
3associate professor of cardiovascular diseases research center school of birjand university of medical sciences
4Birjand University of Medical Science, Ghafary Ave, Birjand, IR Iran
5Birjand university of medical sciense
چکیده
Background: In recent years, there has been a sharp rise in the prevalence of obesity across all age groups, which poses a serious threat to public health. Numerous micronutrients, including magnesium, are deficient in obese people. Magnesium is a vital cofactor for hundreds of enzyme systems and is involved in the metabolism of sugars, proteins, and lipids. Obesity is one of the most significant risk factors associated with the development of glucose intolerance, cardiovascular disease, high blood pressure, and hyperlipidemia. Given the recent rise in obesity at young ages, this study aimed at comparing serum magnesium and blood sugar levels between obese and normal-weight adolescents.
Methods: In this case-control study, fifty-seven 12-18-year-old obese and overweight adolescents (BMI above 85% as the case group) and normal-weight adolescents (BMI between 65% and 85% as the control group) were selected randomly from high schools across Birjand. Upon recruitment and assignment of participants, blood samples were collected and serum magnesium and glucose levels were measured. SPSS 15 software was utilized to analyze the collected data.
Results: Age and gender distributions were similar between the case and control groups (P> 0.05). The mean serum magnesium concentration was significantly lower in the case group than in the control group (P <0.05). The mean blood sugar level in the case group was significantly higher than that in the control group (P <0.05). There was no correlation between blood glucose and magnesium in the two groups (P> 0.05).
Conclusion: The mean serum magnesium concentration of overweight and obese adolescents is lower than that of normal-weight children. Therefore, serum Mg may serve as an early biomarker for predicting obesity-related diseases. Further research is required to evaluate the precise role of magnesium in obesity prevention and to establish the causal relationship between obesity and magnesium deficiency.
کلیدواژه‌ها
Obesity,,؛ ,،magnesium,,؛ ,،fasting blood sugar
مراجع
  1. Namakin K, Hossein Mi, Zardast M, Mohammadifard M. Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and its Clinical Characteristics in Overweight and Obese Children in the South East of Iran, 2017. Hepat Mon. 2018; 18(12):e83525. doi: 10.5812/hepatmon.83525.
  2. Zardast M, Namakin K, Chahkandi T, Taheri F, Kazemi T, Bijari B. Prevalence of metabolic syndrome in elementary school children in East of Iran. J Cardiovasc Thorac Res 2015; 7(4):158-163. doi:10.15171/jcvtr.2015.34.
  3. Nesaee N, Sharifzadeh G, Hoseini M,NamakinM.Comparison of serum levels of osteoprotegerin, insulin, triglyceride, and cholesterol in obese and non-obese children. Int J School Health 2021 8:141–147.
4 Hartwig A. Role of magnesium in genomic stability. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2001; 475(1):113-21. https://doi.org/10.1016/S0027-5107 (01)00074-4.

  1. Agus ZS, Kelepouris E, Dukes I, Morad M. Cytosolic magnesium modulates calcium channel activity in mammalian ventricular cells. American Journal of Physiology-Cell Physiology. 1989; 256(2):C452-C5. https://doi.org/10.1152/ajpcell.1989.256.2.C452.
  2. Song Y, Ridker PM, Manson JE, Cook NR, Buring JE, Liu S. Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older US women. Diabetes care. 2005; 28(6):1438-44. https://doi.org/10.2337/diacare.28.6.1438.
  3. Narayanan S, Scalici P. Serum magnesium levels in pediatric inpatients: a study in laboratory overuse. Hospital pediatrics. 2015; 5(1):9-17. https://doi.org/10.1542/hpeds.2014-0015.
  4. Liu S, Chacko SA. Dietary Mg intake and biomarkers of inflammation and endothelial dysfunction. Magnesium in human health and disease: Springer; 2013. p. 35-50. 10.1007/978-1-62703-044-1_2.
  5. Hassan SAU, Ahmed I, Nasrullah A, Haq S, Ghazanfar H, Sheikh AB, Zafar R, Askar G, Hamid Z, Khushdil A, Khan A. Comparison of Serum Magnesium Levels in Overweight and Obese Children and Normal Weight Children. Cureus. 2017; 9(8):e1607. doi:10.7759/cureus.1607.
  6. Hruby A, McKeown NM, Song Y, Djoussé L. Dietary magnesium and genetic interactions in diabetes and related risk factors: a brief overview of current knowledge. Nutrients. 2013; 5(12):4990-5011. https://doi.org/10.3390/nu5124990.
  7. Wei J, Zeng C, Li X-x, Gong Q-y, Lei G-h, Yang T-b. Association among dietary magnesium, serum magnesium, and diabetes: a cross-sectional study in middle-aged and older adults. Journal of Health, Population and Nutrition. 2016; 35(1):1-6. https://doi.org/10.1186/s41043-016-0071-z.
  8. Bertinato J, Xiao CW, Ratnayake WN, Fernandez L, Lavergne C, Wood C, Swist E. Lower serum magnesium concentration is associated with diabetes, insulin resistance, and obesity in South Asian and white Canadian women but not men. Food & nutrition research. 2015; 59(1):25974. https://doi.org/10.3402/fnr.v59.25974.
  9. Huerta MG, Roemmich JN, Kington ML, Bovbjerg VE, Weltman AL, Holmes VF, Holmes VF, Patrie JT, Rogol AD, Nadler JL. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes care. 2005; 28(5):1175-81. https://doi.org/10.2337/diacare.28.5.1175.
14 Jose B, Jain V, Vikram NK, Agarwala A, Saini S. Serum magnesium in overweight children. Indian pediatrics. 2012; 49(2):109-12. https://doi.org/ 10.1007/ s13312-012-0024-6.

  1. YAKINCI G, PAÇ A, KüÇüKBAY FZ, TAYFUN M, GüL A. Serum zinc, copper, and magnesium levels in obese children. Pediatrics International. 1997; 39(3):339-41. https://doi.org/ 10.1111/ j.1442-200X. 1997. tb03748.x.
  2. Bertinato J, Wang KC, Hayward S. Serum magnesium concentrations in the Canadian population and associations with diabetes, glycemic regulation, and insulin resistance. Nutrients. 2017; 9(3):296. https://doi.org/10.3390/nu9030296.
  3. Zaakouk AM, Hassan MA, Tolba OA. Serum magnesium status among obese children and adolescents. Egyptian Pediatric Association Gazette. 2016; 64(1):32-7. https://doi.org /10. 1016/ j. epag. 2015. 11 .002.
  4. Darvishi L, Ghiasvand R, Ashrafi M, Ashrafzadeh E, Askari G, Shiranian A, Hasanzadeh A. Relationship between junk foods intake and weight in 6-7 years old children, Shahin Shahr and Meymeh, Iran. Journal of education and health promotion. 2013; 2. DOI: 10.4103/2277-9531.106638.
  5. Takaya J, Kaneko K. Small for gestational age and magnesium in cord blood platelets: intrauterine magnesium deficiency may induce metabolic syndrome in later life. Journal of Pregnancy. 2011; 2011. https://doi.org/ 10.1155/ 2011/270474.
  6. Shahbah D, Hassan T, Morsy S, Saadany HE, Fathy M, Al-Ghobashy A, Elsamad N, Emam A, Elhewala A, Ibrahim B, Gebaly SE, Sayed HE, Ahmed H. Oral magnesium supplementation improves glycemic control and lipid profile in children with type 1 diabetes and hypomagnesaemia. Medicine. 2017; 96 (11). doi: 10.1097/ MD. 0000000000006352.
  7. Santhanam K. Association of serum magnesium deficiency with insulin resistance in type 2 diabetes mellitus: Madurai Medical College, Madurai; 2020.
  8. Guerrero-Romero F, Flores-García A, Saldaña-Guerrero S, Simental-Mendía LE, Rodríguez-Morán M. Obesity and hypomagnesemia. European journal of internal medicine. 2016; 34:29-33. https://doi.org/10.1016/j.ejim.2016.06.015.
  9. Piuri G, Zocchi M, Della Porta M, Ficara V, Manoni M, Zuccotti GV, Pinotti L, Maier JA, Cazzola R. Magnesium in obesity, metabolic syndrome, and Type 2 diabetes. Nutrients. 2021; 13(2):320. https://doi.org/10.3390/nu13020320.
  10. Rodríguez-Moran M, Guerrero-Romero F. Oral magnesium supplementation improves the metabolic profile of metabolically obese, normal-weight individuals: a randomized double-blind placebo-controlled trial. Archives of medical research. 2014; 45(5):388-93. https://doi.org/10.1016/j.arcmed.2014.05.003.
  11. Dou M, Ma Y, Han L, Song MM, Wang YG, Yao MX, Sun XF, Li Y, Gao S, Zhang Y. Combined chromium and magnesium decreases insulin resistance more effectively than either alone. Asia Pacific journal of clinical nutrition. 2016; 25(4):747-53. https://search. informit.org /doi/ 10.3316/ ielapa. 369657961017027.
  12. Joris PJ, Plat J, Bakker SJ, Mensink RP. Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial. The American Journal of Clinical Nutrition. 2016; 103(5):1260-6. https://doi.org/10.3945/ajcn.116.131466.
  13. Saris N-EL, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium: an update on physiological, clinical and analytical aspects. Clinica chimica acta. 2000; 294(1-2):1-26. https://doi.org/10.1016/S0009 - 8981(99)00258-2.
28.. Balon TW, Gu J-L, Tokuyama Y, Jasman A, Nadler J. Magnesium supplementation reduces development of diabetes in a rat model of spontaneous NIDDM. American Journal of Physiology-Endocrinology and Metabolism. 1995; 269(4):E745-E52. https://doi.org/10.1152/ajpendo.1995.269.4.E745.

  1. He K, Liu K, Daviglus ML, Morris SJ, Loria CM, Van Horn L, Jacobs Jr DR, Savage PJ. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation. 2006; 113(13):1675-82. https://doi.org/10.1161/CIRCULATIONAHA.105.588327.
30 Hashemipour M, Soghrati M, Malekahmadi M, Soghrati M, Mirmoghtadaei P, Poursafa P, Kelishadi R. Association of Anthropometric Indexes and Cardio-Metabolic Risk factors among Obese Children. ARYA Atherosclerosis. 2010; 5(1).

  1. Chutia H, Lynrah KG. Association of serum magnesium deficiency with insulin resistance in type 2 diabetes mellitus. Journal of laboratory physicians. 2015; 7(02):075-8. DOI: 10.4103/0974-2727.163131.
  2. Chahkandi T, Taheri F, Bijari B, Kazemi T, Namakin K, Zardast M. Prevalence of high normal FBS and prediabetes among adolescents in Birjand, East of Iran, 2012. Journal of Education and Health Promotion. 2015; 4. doi: 10.4103/2277-9531.162389.
آمار
تعداد مشاهده مقاله: 484
تعداد دریافت فایل اصل مقاله: 339