سامانه مدیریت نشریات علمی دانشگاه علوم پزشکی مشهد

Takeda, Kazuya, Kawasaki, Yoshihide, Sakayauchi, Toru, Takahashi, Chiaki, Katagiri, Yu, Tanabe, Takaya, Ishikawa, Yojiro, Fujimoto, Keisuke, Kubozono, Masaki, Kozumi, Maiko, Abe, Keiko, Narazaki, Kakutaro, Tasaka, Shun, Umezawa, Rei, Yamamoto, Takaya, Takahashi, Noriyoshi, Suzuki, Yu, Kishida, Keita, Omata, So, Ito, Akihiro, Jingu, Keiichi. (1401). Clinical significance of completion of radium-223 treatment and acute adverse events in patients with metastatic castration-resistant prostate cancer. , 11(1), 13-22. doi: 10.22038/aojnmb.2022.67136.1468
Kazuya Takeda; Yoshihide Kawasaki; Toru Sakayauchi; Chiaki Takahashi; Yu Katagiri; Takaya Tanabe; Yojiro Ishikawa; Keisuke Fujimoto; Masaki Kubozono; Maiko Kozumi; Keiko Abe; Kakutaro Narazaki; Shun Tasaka; Rei Umezawa; Takaya Yamamoto; Noriyoshi Takahashi; Yu Suzuki; Keita Kishida; So Omata; Akihiro Ito; Keiichi Jingu. "Clinical significance of completion of radium-223 treatment and acute adverse events in patients with metastatic castration-resistant prostate cancer". , 11, 1, 1401, 13-22. doi: 10.22038/aojnmb.2022.67136.1468
Takeda, Kazuya, Kawasaki, Yoshihide, Sakayauchi, Toru, Takahashi, Chiaki, Katagiri, Yu, Tanabe, Takaya, Ishikawa, Yojiro, Fujimoto, Keisuke, Kubozono, Masaki, Kozumi, Maiko, Abe, Keiko, Narazaki, Kakutaro, Tasaka, Shun, Umezawa, Rei, Yamamoto, Takaya, Takahashi, Noriyoshi, Suzuki, Yu, Kishida, Keita, Omata, So, Ito, Akihiro, Jingu, Keiichi. (1401). 'Clinical significance of completion of radium-223 treatment and acute adverse events in patients with metastatic castration-resistant prostate cancer', , 11(1), pp. 13-22. doi: 10.22038/aojnmb.2022.67136.1468
Takeda, Kazuya, Kawasaki, Yoshihide, Sakayauchi, Toru, Takahashi, Chiaki, Katagiri, Yu, Tanabe, Takaya, Ishikawa, Yojiro, Fujimoto, Keisuke, Kubozono, Masaki, Kozumi, Maiko, Abe, Keiko, Narazaki, Kakutaro, Tasaka, Shun, Umezawa, Rei, Yamamoto, Takaya, Takahashi, Noriyoshi, Suzuki, Yu, Kishida, Keita, Omata, So, Ito, Akihiro, Jingu, Keiichi. Clinical significance of completion of radium-223 treatment and acute adverse events in patients with metastatic castration-resistant prostate cancer. , 1401; 11(1): 13-22. doi: 10.22038/aojnmb.2022.67136.1468

Clinical significance of completion of radium-223 treatment and acute adverse events in patients with metastatic castration-resistant prostate cancer

Asia Oceania Journal of Nuclear Medicine and Biology
مقاله 3، دوره 11، شماره 1، فروردین 2023، صفحه 13-22    اصل مقاله (1.28 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22038/aojnmb.2022.67136.1468
نویسندگان
Kazuya Takeda* 1، 2؛ Yoshihide Kawasaki3؛ Toru Sakayauchi4؛ Chiaki Takahashi5؛ Yu Katagiri6؛ Takaya Tanabe7؛ Yojiro Ishikawa8؛ Keisuke Fujimoto9؛ Masaki Kubozono10؛ Maiko Kozumi10؛ Keiko Abe11؛ Kakutaro Narazaki12؛ Shun Tasaka12؛ Rei Umezawa2؛ Takaya Yamamoto2؛ Noriyoshi Takahashi2؛ Yu Suzuki2؛ Keita Kishida2؛ So Omata2؛ Akihiro Ito3؛ Keiichi Jingu2، 13
1Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
2Department of Radiation Oncology, South Miyagi Medical Center, Ogawara , Japan
3Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan
4Department of Radiation Oncology, Osaki Citizen Hospital, Osaki, Japan
5Department of Radiation Oncology, Iwate Prefectural Isawa Hospital, Oshu, Japan
6Department of Radiation Oncology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan
7Department of Radiation Oncology, Tohoku Rosai Hospital, Sendai, Japan
8Department of Radiation Oncology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
9Department of Radiation Oncology, Iwaki City Medical Center, Iwaki, Japan
10Department of Radiation Oncology, Miyagi Cancer Center, Natori, Japan
11Department of Radiation Oncology, Iwate Prefectural Iwai Hospital, Ichinoseki, Japan
12Department of Radiation Oncology, Sendai Medical Center, Sendai, Japan
13Department of Radiation Oncology, Iwate Prefectural Ofunato Hospital, Ofunato, Japan
چکیده
Objective(s): In the treatment of castration-resistant prostate cancer (CRPC) with bone metastases, radium-223 dichloride (Ra-223) is the only bone-targeted drug that shows survival benefits. Completing six courses of Ra-223 treatment is thought to be associated with better patient survival, but this treatment has a relatively high rate of acute adverse events.
Methods: This retrospective study included 85 patients from 12 institutions in Japan to investigate the clinical significance of the completion of Ra-223 treatment and acute adverse events in CRPC patients.
Results: Six courses of Ra-223 treatment were completed in 65.9% of the patients. Grade 3 or higher acute adverse events were observed in 27.1% of patients. The prostate specific antigen and alkaline phosphatase declined at 26.9% and 87.9%, respectively. The overall survival rates at 12 and 24 months were 80.7% and 63.2%, respectively. Both completion of six courses of Ra-223 treatment and absence of grade 3 or higher acute adverse events were associated with longer overall survival. In univariate analysis, factors related to the history of treatment (five or more hormone therapy agents and cytotoxic chemotherapy) and hematological parameters (Prostate specific antigen (PSA) doubling time, alkaline phosphatase, hemoglobin, albumin, and serum calcium) were associated with completing six courses of Ra-223 treatment without experiencing grade 3 or higher acute adverse events. Multivariate analysis showed that a history of chemotherapy, PSA doubling time, hemoglobin, and serum calcium showed statistical significance. We built a predictive score by these four factors. Patients with lower scores showed higher rates of treatment success (p<0.001) and longer overall survival (p<0.001) with statistical significance.
Conclusions: Accomplishing six courses of Ra-223 treatment without grade 3 or higher acute adverse events was a prognostic factor in patients with mCRPC treated with Ra-223. We built a predictive score of treatment success and need future external validation.
کلیدواژه‌ها
Radium-223 dichloride؛ Bone metastasis؛ Castration-resistant prostate cancer؛ Radioisotope therapy
مراجع
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آمار
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