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Mohamad, Soad, Badwy, Ahmed, El-Sabaa, Ramy, Ahmad, Hosam, Mohamed, Asmaa. (1401). Study of Different Local Treatments of Post COVID-19 Smell Dysfunction. , 34(6), 281-288. doi: 10.22038/ijorl.2022.58339.3012
Soad A. Mohamad; Ahmed M. Badwy; Ramy M. El-Sabaa; Hosam M. Ahmad; Asmaa S. Mohamed. "Study of Different Local Treatments of Post COVID-19 Smell Dysfunction". , 34, 6, 1401, 281-288. doi: 10.22038/ijorl.2022.58339.3012
Mohamad, Soad, Badwy, Ahmed, El-Sabaa, Ramy, Ahmad, Hosam, Mohamed, Asmaa. (1401). 'Study of Different Local Treatments of Post COVID-19 Smell Dysfunction', , 34(6), pp. 281-288. doi: 10.22038/ijorl.2022.58339.3012
Mohamad, Soad, Badwy, Ahmed, El-Sabaa, Ramy, Ahmad, Hosam, Mohamed, Asmaa. Study of Different Local Treatments of Post COVID-19 Smell Dysfunction. , 1401; 34(6): 281-288. doi: 10.22038/ijorl.2022.58339.3012

Study of Different Local Treatments of Post COVID-19 Smell Dysfunction

Iranian Journal of Otorhinolaryngology
مقاله 2، دوره 34، شماره 6، بهمن و اسفند 2022، صفحه 281-288    اصل مقاله (1.06 M)
نوع مقاله: Original
شناسه دیجیتال (DOI): 10.22038/ijorl.2022.58339.3012
نویسندگان
Soad A. Mohamad1؛ Ahmed M. Badwy2؛ Ramy M. El-Sabaa3؛ Hosam M. Ahmad4؛ Asmaa S. Mohamed* 5
1Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Deraya University, Minia, Egypt.
2Department of Otorhinolaryngology, Faculty of Medicine, Minia University, Minia, Egypt.
3Department of Clinical Pharmacy, Faculty of Pharmacy, Menoufia and Deraya Universities, Egypt.
4Departments of Internal Medicine and Biomedical Chemistry, Egypt Ministry of Health and population, Minia, Egypt.
5Department of Clinical Pharmacy, Faculty of Pharmacy, Port Said University, Port said, Egypt.
چکیده
Introduction:
This study was designed to differentiate between the impact of the topical nasal spray of corticosteroids, antihistamines, a combination of them, and normal 0.2% saline in treating patients with post-coronavirus disease 2019 (COVID-19) smell dysfunction.
Materials and Methods:
Patients with hyposmia or anosmia (n = 240), who recently recovered from COVID-19, were enrolled in this trial and were randomly assigned to four parallel groups. Group I (G1) received a combination of topical corticosteroid and antihistamine nasal spray (n = 60). Group II (G2) received topical corticosteroid nasal spray (n = 60). Group III (G3) received antihistamine nasal spray (n = 60). Group IV (G4) received 0.2% normal nasal saline nasal spray (n = 60). The treatments were used in all groups for 3 weeks. The sense of smell was assessed using the butanol threshold and discrimination tests. The smell tests were evaluated weekly for 3 weeks.
Results:
The mean age of the patients was 51.9 ± 7.1 years; moreover, 83.8% and 16.3% were male and female, respectively. The results of the smell tests in the first week significantly improved with those in the third week (P< 0.001). The greatest degree of improvement was found in the first group, followed by the second, third, and fourth groups.
Conclusions:
The results suggest the ability of combination therapy of corticosteroid and antihistamine nasal spray to manage post-COVID-19 hyposmia or anosmia; however, this combination therapy was not superior to corticosteroid nasal spray. Trial registration ID: UMIN000043537
کلیدواژه‌ها
Antihistamines؛ Butanol threshold test؛ Corticosteroids؛ Discrimination test؛ Smell dysfunction؛ Post COVID-19
مراجع
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