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Sharif, Mohammad Reza, Kheirkhah, Davood, azadchehr, mohammad javad, Sharif, Alireza, Astaneh, Forughosadat. (1401). Evaluation of Clinical Manifestations, Laboratory Findings and Outcome of Children with Covid-19. , 10(10), 16854-16868. doi: 10.22038/ijp.2022.67412.5038
Mohammad Reza Sharif; Davood Kheirkhah; mohammad javad azadchehr; Alireza Sharif; Forughosadat Astaneh. "Evaluation of Clinical Manifestations, Laboratory Findings and Outcome of Children with Covid-19". , 10, 10, 1401, 16854-16868. doi: 10.22038/ijp.2022.67412.5038
Sharif, Mohammad Reza, Kheirkhah, Davood, azadchehr, mohammad javad, Sharif, Alireza, Astaneh, Forughosadat. (1401). 'Evaluation of Clinical Manifestations, Laboratory Findings and Outcome of Children with Covid-19', , 10(10), pp. 16854-16868. doi: 10.22038/ijp.2022.67412.5038
Sharif, Mohammad Reza, Kheirkhah, Davood, azadchehr, mohammad javad, Sharif, Alireza, Astaneh, Forughosadat. Evaluation of Clinical Manifestations, Laboratory Findings and Outcome of Children with Covid-19. , 1401; 10(10): 16854-16868. doi: 10.22038/ijp.2022.67412.5038

Evaluation of Clinical Manifestations, Laboratory Findings and Outcome of Children with Covid-19

Journal of Pediatric Perspectives
مقاله 11، دوره 10، شماره 10، دی 2022، صفحه 16854-16868    اصل مقاله (543.89 K)
نوع مقاله: original article
شناسه دیجیتال (DOI): 10.22038/ijp.2022.67412.5038
نویسندگان
Mohammad Reza Sharif1؛ Davood Kheirkhah2؛ mohammad javad azadchehr3؛ Alireza Sharif4؛ Forughosadat Astaneh* 5
1Professor of Pediatric Infectious Disease, Department of Pediatrics, School of Medicine, Infectious Diseases Research Center, Shahid Beheshti Hospital, Kashan University of Medical Sciences
2Associate professor of pediatrics diseases, Department of Pediatrics, School of Medicine, Infectious Diseases Research Center, Shahid Beheshti Hospital, Kashan University of Medical Sciences
3MSC biostatistics, Infectious Diseases Research Center, Kashan University of Medical Science, Iran
4Associate professor of Infectious diseases, Department of Infectious Diseases, School of Medicine, Infectious Diseases Research Center, Shahid Beheshti Hospital, Kashan University of Medical Sciences
5Specialist (Pediatrician) Department of Pediatrics, Faculty of Medicine, Kashan University of Medical Science, Iran
چکیده
Background: Coronavirus, a common infectious disease in the 21st century, has not been studied enough in children. Therefore, this study aimed to investigate the clinical manifestations, laboratory findings, and outcomes of children with Covid-19 admitted to Shahid Beheshti Hospital in Kashan during 2020-2022.
Method: In this retrospective cohort study, the medical records of children with covid-19 referred to Shahid Beheshti hospital in Kashan between February 2020 and March 2022 were reviewed. The information extracted from the patient's medical records included demographic variables, clinical characteristics, laboratory findings, and the outcome of covid-19. The collected data were analyzed through SPSS 16, using descriptive statistics (frequency distribution, mean and standard deviation) and inferential statistics (chi-square test and ANOVA).
Result: The findings of 271 children (159 boys; 52% of the age group≤5 years) showed that fever (57.6%), cough (39.9%), nausea-vomiting (31.7%), and diarrhea were the most common clinical symptoms. Also, the majority of patients were in the abnormal range in terms of Monocyte (89.3%), PTT (84.7%), Lymphocyte (83.6%), Neutrophil (80.4%), and LDH (74.5%). Pulmonary involvement was present in 12.5% of children. Finally, four children (1.5%) died.
Conclusion: Severity of lung involvement and the outcome of the covid-19 disease (admission to the ICU and death) among children were at a low level, and in fact, it shows the better condition of children than adults in relation to this disease.
کلیدواژه‌ها
Clinical manifestations,,؛ ,،Laboratory findings,,؛ ,،Children,,؛ ,،Covid-19
مراجع
  1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. jama. 2020; 323(13):1239-42.
  2. Distribution of coronavirus cases in Italy as of July 20, 2022, by age group. Statista Research Department; 2022.
  3. Age distribution of coronavirus (COVID-19) cases in South Korea as of July 1, 2022. Statista Research Department; 2022.
  4. Posfay-Barbe KM, Wagner N, Gauthey M, Moussaoui D, Loevy N, Diana A, L'Huillier AG. COVID-19 in children and the dynamics of infection in families. Pediatrics. 2020; 146(2).
  5. Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, Holden KA, Read JM, Dondelinger F, Carson G, Merson L, Lee J, Plotkin D, Sigfrid L, Halpin S, Jackson C, Gamble C, Horby PW, Nguyen-Van-Tam JS, Ho A, Russell CD, Dunning J, Openshaw PJ, Baillie JK, Semple MG, ISARIC4C investigators. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. bmj. 2020; 369.
  6. Stokes EK, Zambrano LD, Anderson KN, Marder EP, Raz KM, Felix SEB, Tie Y, Fullerton KE. Coronavirus disease 2019 case surveillance—United States, january 22–May 30, 2020. Morbidity and Mortality Weekly Report. 2020; 69(24):759.
  7. Zimmermann P, Pittet LF, Curtis N. How common is long COVID in children and adolescents? The Pediatric infectious disease journal. 2021; 40(12):e482.
  8. Ashkenazi-Hoffnung L, Shmueli E, Ehrlich S, Ziv A, Bar-On O, Birk E, Lowenthal A, Prais D. Long COVID in children: observations from a designated pediatric clinic. The Pediatric infectious disease journal. 2021; 40(12):e509.
  9. Nikolopoulou GB, Maltezou HC. COVID-19 in children: where do we stand? Archives of medical research. 2021.
  10. Howard‐Jones AR, Burgner DP, Crawford NW, Goeman E, Gray PE, Hsu P, Kuek S, McMullan BJ, Tosif S, Wurzel D, Bowen AC, Danchin M, Koirala A, Sharma K, Yeoh DK, Britton PN. COVID‐19 in children. II: Pathogenesis, disease spectrum and management. Journal of Pediatrics and Child Health. 2022; 58(1):46-53.
  11. Frenkel LD, Gomez F, Bellanti JA, editors. COVID-19 in children: Pathogenesis and current status. Allergy Asthma Proc; 2021.
  12. Han MS, Choi EH, Chang SH, Jin B-L, Lee EJ, Kim BN, Kim MK, Doo K, Seo JH, Kim YJ, Kim YJ, Park JY, Suh SB, Lee H, Cho EY, Kim DH, Kim JM, Kim HY, Park SE, Lee JK, Jo DS, Cho SM, Choi JH, Jo KJ, Choe YJ, Kim KH, Kim JH. Clinical characteristics and viral RNA detection in children with coronavirus disease 2019 in the Republic of Korea. JAMA pediatrics. 2021; 175(1):73-80.
  13. Liguoro I, Pilotto C, Bonanni M, Ferrari ME, Pusiol A, Nocerino A, Vidal E, Cogo P. SARS-COV-2 infection in children and newborns: a systematic review. European journal of pediatrics. 2020; 179(7):1029-46.
  14. Mehta NS, Mytton OT, Mullins EW, Fowler TA, Falconer CL, Murphy OB, Langenberg C, Jayatunga WJP, Eddy DH, Nguyen-Van-Tam JS. SARS-CoV-2 (COVID-19): what do we know about children? A systematic review. Clinical Infectious Diseases. 2020; 71(9):2469-79.
  15. Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, Tong S. Epidemiology of COVID-19 among children in China. Pediatrics. 2020; 145(6).
  16. Zachariah P, Johnson CL, Halabi KC, Ahn D, Sen AI, Fischer A, Banker SL, Giordano M, Manice CS, Diamond R, Sewell TB, Schweickert AJ, Babineau JR, Carter RC, Fenster DB, Orange JS, McCann TA, Kernie SG, Saiman L, Columbia Pediatric COVID-19 Management Group. Epidemiology, clinical features, and disease severity in patients with coronavirus disease 2019 (COVID-19) in a children’s hospital in New York City, New York. JAMA pediatrics. 2020; 174(10):e202430-e.
  17. Tian Y, Rong L, Nian W, He Y. Review article: gastrointestinal features in COVID-19 and the possibility of fecal transmission Aliment Pharmacol Ther 51: 843-851. Published online. 2020.
  18. Part M, Lighter J, Pellett Madan R, Raabe V, Shust G, Ratner A. SARS-CoV-2 infection (COVID-19) in febrile infants without respiratory distress [manuscript published online ahead of print April 17, 2020]. Clin Infect Dis. 2020; 10.
  19. Feld L, Belfer J, Kabra R, Goenka P, Rai S, Moriarty S, Barone S. A case series of the 2019 novel coronavirus (SARS-CoV-2) in 3 febrile infants in New York. Pediatrics. 2020; 146(1).
  20. Meslin P, Guiomard C, Chouakria M, Porcher J, Duquesne F, Tiprez C, Zemouri N. Coronavirus disease 2019 in newborns and very young infants: a series of six patients in France. The Pediatric Infectious Disease Journal. 2020; 39(7):e145-e7.
  21. Ng KF, Bandi S, Bird PW, Tang JW-T. COVID-19 in neonates and infants: progression and recovery. The Pediatric infectious disease journal. 2020; 39(7):e140-e2.
  22. Mithal LB, Machut KZ, Muller WJ, Kociolek LK. SARS-CoV-2 infection in infants less than 90 days old. The Journal of pediatrics. 2020; 224:150-2.
  23. Vanhems P, Endtz H, Dananché C, Komurian-Pradel F, Picot VS. Comparison of the clinical features of SARS-CoV-2, other coronavirus and influenza infections in infants less than 1-year-old. The Pediatric infectious disease journal. 2020; 39(7):e157.
  24. Grimaud E, Challiol M, Guilbaud C, Delestrain C, Madhi F, Ngo J, Epaud R, Nattes E. Delayed acute bronchiolitis in infants hospitalized for COVID‐19. Pediatric Pulmonology. 2020.
  25. Du W, Yu J, Wang H, Zhang X, Zhang S, Li Q, Zhang Z. Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. Infection. 2020; 48(3):445-52.
  26. Chang T-H, Wu J-L, Chang L-Y. Clinical characteristics and diagnostic challenges of pediatric COVID-19: a systematic review and meta-analysis. Journal of the Formosan Medical Association. 2020; 119 (5):982-9.
  27. Han Yn, Feng Zw, Sun Ln, Ren Xx, Wang H, Xue Ym, Wang Y, Fang Y. A comparative‐descriptive analysis of clinical characteristics in 2019‐coronavirus‐infected children and adults. Journal of medical virology. 2020; 92(9):1596-602.
  28. Tezer H, Demirdağ TB. Novel coronavirus disease (COVID-19) in children. Turkish journal of medical sciences. 2020; 50(9):592-603.
  29. Kompaniyets L, Agathis NT, Nelson JM, Preston LE, Ko JY, Belay B, Pennington AF, Danielson ML, DeSisto CL, Chevinsky JR, Schieber LZ, Yusuf H, Baggs J, Kenzie WRM, Wong KK, Boehmer TK, Gundlapalli AV, Goodman AB. Underlying medical conditions associated with severe COVID-19 illness among children. JAMA network open. 2021; 4(6):e2111182-e.
  30. Meena J, Yadav J, Saini L, Yadav A, Kumar J. Clinical features and outcome of SARS-CoV-2 infection in children: a systematic review and meta-analysis. Indian pediatrics. 2020; 57(9):820-6.
  31. Patel NA. Pediatric COVID-19: Systematic review of the literature. American journal of otolaryngology. 2020; 41(5):102573.
  32. Henry BM, Lippi G, Plebani M. Laboratory abnormalities in children with novel coronavirus disease 2019. Clinical Chemistry and Laboratory Medicine (CCLM). 2020; 58(7):1135-8.
  33. Kosmeri C, Koumpis E, Tsabouri S, Siamo E, Makis A. Hematological manifestations of SARS‐CoV‐2 in children. Pediatric blood & cancer. 2020; 67(12):e28745.
  34. Parri N, Lenge M, Buonsenso D. Children with Covid-19 in pediatric emergency departments in Italy. New England Journal of Medicine. 2020; 383(2):187-90.
  35. Samy M, Khalaf LM. Chest CT features of COVID-19 pediatric patients presented with upper respiratory symptoms. Egyptian Journal of Radiology and Nuclear Medicine. 2021; 52(1):1-5.
  36. Sun D, Li H, Lu X-X, Xiao H, Ren J, Zhang F-R, Liu Z-S. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World Journal of Pediatrics. 2020; 16(3):251-9.
  37. Hoang A, Chorath K, Moreira A, Evans M, Burmeister-Morton F, Burmeister F, Naqvi R, Petershack M, Moreira A. COVID-19 in 7780 pediatric patients: a systematic review. EClinicalMedicine. 2020; 24:100433.
  38. Ludvigsson JF. Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults. Acta paediatrica. 2020; 109(6):1088-95.
  39. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395(10229):1054-62.
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